OBJECTIVE: To analyze the effects of type-1 diabetes mellitus (DM1) induction on systemic hemodynamic and ventricular function of normotensive and hypertensive rats. MATERIALS AND METHODS: DM1 was induced by streptozotocin in Wistar rats (WST), borderline hypertensive rats (BHR) and spontaneously hypertensive rats (SHR). The systemic hemodynamic was evaluated by thermodilution and ventricular function by Langendorff preparation. RESULTS: DM1-induction increased tail arterial pressure of WST and BHR. DM1 also increased total peripheral resistance in WST and decrease in cardiac output stroke volume in WST and BHR. Systolic function indexes were reduced and ventricular stiffness increased in all WST-diabetic rats. All of these effects were more prominent on diabetic WST rats. CONCLUSION: The DM1 in rats was accompanied by important changes in both systolic and diastolic heart function leading to significant changes in the systemic hemodynamics that were not significantly enhanced by hypertension.
Diabetes mellitus, experimental; hypertrophy, left ventricular; ventricular function, left; hemodynamics
