Recently, a great deal of attention has focused on the growth regulatory effects of androgens in prostate cells. This has also resulted in much interest in the role of these steroid hormones in the development and maintenance of both normal and neoplastic prostate. However, it has not been possible to identify the exact relationship between androgenic hormone levels and the risk of this disease. The hormone-androgen receptor complex, by association with the DNA androgen response elements, specifically promotes the growth of the prostate gland. It has been recognized that there is a close relationship between the androgen mediated signaling pathway and those promoted by peptide growth factors. More insights are being gained into these complex interactions, some of which may lead to novel therapeutic maneuvers.
Prostate; Prostatic neoplasia; Androgens; Growth factors; Therapy
