Total or partial X chromosome loss, hypergonadotrophic hypogonadism and short stature characterize Turner syndrome (TS). Delayed puberty and hypoestrogenism are the determinant factors of osteoporosis in TS, and the compromise of intrinsic bone defect is yet obscure. The aim of this study was to evaluate the association between bone mineral density (BMD) and chronological and bone age, weight, height, karyotype, associated diseases, bone age and estrogen therapy in TS patients. We performed a transversal study with areal BMD of L2-L4 with DEXA in 34 patients with cytogenetic diagnosis of TS. Statistical differences were present concerning age and height, since TS patients with z BMD <2.5 were older and taller. The z BMD analysis revealed lower values in patients who needed estrogen therapy. These results suggest that in patients with TS, age and estrogen therapy could be associated with low BMD.
Bone mineral density; Turner syndrome; Estrogen; Osteoporosis
