Comparison of echocardiographic parameters in Santa Inês sheep breed and healthy Brazilian human adults

Almeida, V.G.F.; Teixeira, A.L.S.; Gouvêa, L.V.; Silva, S.S.M.; Lessa, D.A.B.; Alencar, N.X.

doi:10.1590/1678-4162-13211

home Sumário navigate_before Anterior Atual Seguinte navigate_next

home Sumário

Original Article - Veterinary Medicine • Arq. Bras. Med. Vet. Zootec. 77 (2) • Mar-Apr 2025 • https://doi.org/10.1590/1678-4162-13211 linkcopy

Comparison of echocardiographic parameters in Santa Inês sheep breed and healthy Brazilian human adults

[Comparação de parâmetros ecocardiográficos em ovinos da raça Santa Inês e adultos humanos brasileiros saudáveis]

Authorship SCIMAGO INSTITUTIONS RANKINGS

ABSTRACT

The aim of this study was to compare the values of echocardiographic parameters in healthy Santa Inês sheep with standardized values for normal Brazilian human adults. Two-dimensional echocardiography, Movement mode, and pulse wave and color flow Doppler were performed in 39 non-sedated young adult sheep of Santa Inês breed. Dimensions such as the end-diastolic diameter, ejection fraction, and shortening fraction were similar to those of Brazilian human adults. The end-diastolic and -systolic volumes were within the intervals established by the American Society of Echocardiography and the European Association of Echocardiography for normal human adults; guidelines followed in Brazil as references for humans. The normalized end-diastolic diameter exceeded the normal upper limit but approached it when the index was corrected with the cardiac mass/body surface area of sheep in relation to humans. Diastolic parameters were also within normal human intervals, except for a slightly shorter Mitral E-wave deceleration time. We conclude that the echocardiographic parameters of the systolic and diastolic performance of the left ventricle in Santa Inês sheep can be reliably extrapolated to that of Brazilian human adults, thus supporting the use of national sheep models in human heart disease research.

Keywords:
heart disease; sheep models; echocardiographic; Santa Inês

Parameter (unit)	Sheep: mean±SD (amplitude)	Sheep: normal distribution	Humans: mean±SD (amplitude) (*Ângelo et al., 2007*)	p-value	Sheep: normalized value by mean BSA±SD	p-value	Humans: intervals (ASE-EAE)
LVIDd (mm)	37.16±4.95 (22.60-51.10)	Yes	45.50^a±3.90 (40.00-52.00)	<0.0001	33.48b±2.60mm/m²	0.0700	24-31mm/m²
LVIDs (mm)	22.69±3.41 (17.10-32.60)	Yes	26.80±3.30 (23.20-31.50)	<0.0001	-	-	-
LVPWd (mm)	9.50±2.55 (6.60-13.50)	No	-	-	-	-	6-9mm
LVPWs (mm)	14.00±2.55 (8.70-18.00)	No	8.00±0.70 (7.00-9.30)	<0.0001	-	-	-
EDV (mL)	55.20±15.15 (34.20-124.40)	No	-		49.73±7.93 ml/m²	<0.0001	35-70ml/m²
ESV (mL)	18.19±7.15 (8.50-42.80)	Yes	-	-	16.39±3.74ml/m²	0.0001	12-30ml/m²
EF (%)	70.21±7.70 (52.80-83.53)	Yes	71.50±3.10 (67.00-76.00)	0.0001	-	-	27-45
SF (%)	39.43±6.47 (26.61-52.64)	Yes	40.70±2.60 (37.00-45.00)	<0.0001	-	-	>55
Ae/Ao	1.2±0.18 (0.88-1.65)	Yes	-	-	-	-	-

Parameter (unit)	Sheep: mean±SD (amplitude)	Sheep: normal distribution	Human: mean±SD (amplitude)	p-value	Humans: intervals (ASE-EAE)
VelEMit (cm/s)	64±12 (46-92)	Yes	72±14	<0.0001	-
VelAMit (cm/s)	54±11 (33-82)	Yes	40±10	<0.0001	-
Mitral E/A waves	1.20^a±0.16 (0.90-1.59)	Yes	1.53^b±0.40	0.0040	0.73-2.33
E-wave DT(ms)	129.13±37.53 (54.00-225.00)	Yes	166.00±14.00	<0.0001	138-194
IVRT(ms)	77.45±23.23 (21.00-121.00)	Yes	67.00±8.00	<0.0001	51-83

vertical_align_top show_chart

more_horiz close
- image
- translate
- link
- article
- vertical_align_top
- file_download
- show_chart
- image
- translate
- link
- article

location_on

Universidade Federal de Minas Gerais, Escola de Veterinária Caixa Postal 567, 30123-970 Belo Horizonte MG - Brazil, Tel.: (55 31) 3409-2041, Tel.: (55 31) 3409-2042 - Belo Horizonte - MG - Brazil
E-mail: abmvz.artigo@gmail.com

rss_feed Acompanhe os números deste periódico no seu leitor de RSS

[TFN1] SD: standard deviation; BSA: body surface area; ASE: American Society of Echocardiography; EAE: European Association of Echocardiography; LVIDd: left ventricular end-diastolic diameter; LVIDs: left ventricular end-systolic diameter; LVPWd: left ventricular diastolic wall thickness; LVPWs: left ventricular systolic wall thickness; EDV: end-diastolic volume; ESV: end-systolic volume; EF: ejection fraction; SF: shortening fraction; Ao: measurement of the aortic root; Ae: left atrium. Different letters in the lines indicate that there is statistical difference, by t-test or Mann-Whitney test.