Beneath the surface: a case report of metastatic iridociliary ring melanoma treated with pembrolizumab

Abaixo da superfície: relato de caso de melanoma metastático iridociliar em anel tratado com pembrolizumabe

ABSTRACT

Iridociliary ring melanoma is an uncommon type of uveal melanoma. Clinical manifestation varies from asymptomatic cases to masquerade syndromes mimicking refractory glaucoma. Treatment options include radiotherapy and enucleation. Management of metastatic uveal melanoma remains discouraging. Novel therapies using immune checkpoint inhibitors are currently under study. We present a case of a 54-year-old Hispanic woman with progressive vision loss due to metastatic ring melanoma with anterior chamber seeding treated with pembrolizumab.

Keywords:
Uveal neoplasms/complication; Melanoma; Iris neoplasm/secondary; Ciliary body; Antibody, monoclonal, humanized; Immune checkpoint inhibitor; Humans; Case report