Treatment of orbital lymphatic malformation with oral sirolimus: a case report

Malformação linfática orbital tratada com sirolimo oral: relato de caso

ABSTRACT

It is estimated that lymphatic malformations in children account for 6% of all benign vascular malformations. New medical therapies have been developed for the management of lymphatic orbital disease. The purpose of this article was to describe a clinical case of orbital venolymphatic malformation in a 10-year-old boy, causing proptosis and palpebral edema. The lesion was initially treated with local sclerotherapy. However, the lesion relapsed, and was successfully treated with oral sirolimus. Prospective studies are warranted to determine the appropriate dose and extend the indications of sirolimus in these patients.

Keywords:
Lymphatic abnormalities/drug therapy; Orbit/pathology; Exophthalmos; Magnetic resonance imaging; Sirolimus/therapeutic use; Child