Purpose: The author describes a case of bilateral subretinal and sub-RPE hemorrhage due to age related macular degeneration treated with injections of tPA and perfluoropropane gas. Case report: Two eyes of a patient with subretinal and sub-RPE macular hemorrhage received injections of 25 mug of tPA and 0,3 mL of C3F8. The patient was assessed regarding visual acuity, retinography and fluoresceinography before and after the procedure. Results: One week after treatment, both eyes presented with complete resolution of subfoveal hemorrhage, however traces of subretinal hemorrhage were found in both eyes, mainly in the left eye. Sub-RPE hemorrhage remained the same during the treatment of the left eye. Visual acuity improved in both eyes, specifically in the right eye. Conclusion: Intravitreal injection of tPA and perfluoropropane gas seems to be an alternative procedure in the treatment of subretinal hemorrhage due to age related macular degeneration, however, sub-RPE hemorrhage remains a therapeutic challenge. Further studies are necessary.
Tissue plasminogen activator; Retinal hemorrhage; Macular degeneration; Aging
