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Correlation and topographic match between nerve fiber layer thickness and visual field in primary open angle glaucoma

Purpose: To determine the relationship between nerve fiber layer thickness detected by scanning laser polarimetry (GDx) and visual field function measured by automated conventional white-on-white perimetry. Methods: 82 eyes of 48 open angle glaucoma patients were studied. The following correlations were inves-tigated: 1- Correlation between mean sensitivity of 4 quadrants plus the fixation point, in dBs, and the mean of the nerve fiber layer thickness of the correspondent retina, in micra. 2- Correlation between mean sensitivity of 4 quadrants plus the fixation point, in dBs, and the mean of the nerve fiber layer thickness of the correspondent retina, in micra, in the patients classified according to the amount of visual field loss. 3- Correlation between the global indices of visual field and the numeric indices of GDx. 4- Correlation between the mean of "total deviation" of visual field and the "deviation from normal" of GDx. 5- Topographic match between visual field and retinal nerve fiber layer thickness changes. Statistical analysis was performed using the Spearmann coeficient correlation test. Results: We observed a very poor correlation regarding: 1- total GDx and VF total; superior GDx and nasal inferior VF; inferior GDx and nasal superior VF; nasal GDx and temporal VF; superior GDx and inferior VF; inferior GDx and superior VF. 2- inferior GDx and nasal superior VF (severe eyes). 3- Normal eyes: PSD and EM; CPSD and SI. Mild glaucoma eyes: SF and SN. Severe glaucoma eyes: MD and SN; MD and EM; MD and S; CPSD and EM. 4- DN t and TD t; DN s and TD ni; DN i and TD ns. 5- A positive topographic match in 51.43%. Conclusion: There is no good correlation between the two examinations.

Glaucoma; Nerve fibers; Topography; Retina; Visual fields


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