Abstract
Purpose:
To present an alternative experimental model of third degree burn of easy reproducibility.
Methods:
Eighteen male Wister rats were randomly divided into three groups, 6 of which were allocated to each group. A soldering iron coupled to an aluminum plate was used to produce burn, at a temperature of 150ºC, with different exposure times per group. Group 5 (G5) animals were burned at 150°C with exposure time of 5 seconds; Group 10 (G10) the animals were burned at 150°C with exposure time of 10 seconds and group 15 (G15) the animals were burned at 150°C with exposure time of 15 seconds.
Results:
Histopathological analyzes showed that all three groups had similar morphological characteristics, with total thickness involvement.
Conclusion:
The technique is effective to reproduce a third degree burn and suggests the temperature of 150ºC with 5 seconds of exposure in order to minimize the risks to the animals.
Key words:
Burns; Models, Animal; Skin; Rats
