PURPOSE: Evaluate the effects of propofol as inhibitor of tissue lesion in mesenteric ischemia and reperfusion in rats. METHODS: Forty rats Wistar were submitted to anesthesia and middle laparotomy. Intestinal ischemia was obtained by false ligature of cranial mesenteric artery by thirty minutes. Then, the tissue was reperfused for sixty minutes. The half of the animals received physiologic solution 0,9% 10 ml/kg/h (control group) by intravenous infusion; the other half received propofol 20 mg/kg/h by same way (propofol group). At the end, a segment of intestine was taken for histologycal analysis. The results were analyzed in agreement with CHIU et al 80 classification and the statistical analysis was done. RESULTS: In the control group was founded 5 rats with classification grade 2; 8 with classification grade 3; 3 with classification grade 4 and 4 rats with grade. In the propofol group was found 6 rats with classification grade 1; 11 with classification grade 2 and 3 with classification grade 3. The classification media was 3,3 for control group and 1,85 for the propofol group. The variation in the two groups was considered statistically significant (P < 0,05). CONCLUSION: The propofol minimize the tissue lesion in mesenteric ischemia and reperfusion in rats.
Propofol; Ischemia; Reperfusion
