OBJECTIVE: To evaluate the effect of tamoxifen in the lipidic and renal profile in diabetic and control rats. METHODS: 40 female Wistar rats had been used (180-220g corporal weight), divided randomly in 4 groups: C (n=10, received vehicle), T (n=10, treated with tamoxifen, 0.3mg/kg/day), D (n=10, diabetic induced by streptozotocin, 45mg/Kg) and DT (n=10, diabetic treated with tamoxifen). Glucose, total cholesterol, triglyceride, total proteins, albumin, urea and creatinin were analyzed using Labtest Kits through the Cobas Mira analyzer (Germany, 1996). RESULTS: Group T presented a reduction of total cholesterol and triglyceride in relation to C, and group D an increase in relation to the other ones. About the total proteins it was observed an increasing in Group T in relation to C. The albumin diminished in groups D and DT in relation to C and T. The urea levels increased in groups D and DT in relation to C and T. CONCLUSION: In relation to the lipidic profile it was evidenced that during the period of 60 days the treatment with tamoxifen promoted a reduction in cholesterol and triglyceride levels in the serum, even associated to the condition of Diabetes mellitus.
Diabetes mellitus; Tamoxifen; Total cholesterol; Triglyceride
