Circulating omentin-1 might be associated with metabolic health status in different phenotypes of body size

Alizadeh, Shahab; Mirzaei, Khadijeh; Mohammadi, Chonur; Keshavarz, Seyed Ali; Maghbooli, Zhila

doi:10.1590/2359-3997000000269

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Archives of Endocrinology and Metabolism

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Original Article • Arch. Endocrinol. Metab. 61 (6) • Dec 2017 • https://doi.org/10.1590/2359-3997000000269 copy

Circulating omentin-1 might be associated with metabolic health status in different phenotypes of body size

Authorship SCIMAGO INSTITUTIONS RANKINGS

ABSTRACT

Objective

Adipokines are mediators of body composition and are involved in obesity complications. This study aimed to assess the association of circulating omentin-1, vaspin, and RBP-4 with body composition indices and metabolic health status (MHS) in different phenotypes of body size.

Subjects and methods

A total of 350 subjects were included in the current cross-sectional study. Body composition was measured using a body composition analyzer, and serum concentrations of omentin-1, vaspin, and RBP-4 were assessed by ELISA kits.

Results

Circulating omentin-1 was significantly (OR = 1.81, 95% CI: 1.00-1.91, P = 0.01) and marginally (OR = 1.63, 95%CI: 1.00-1.75, P = 0.06) associated with MHS in the overweight and obese subjects, respectively. But no association was seen between omentin-1 and MHS in normal-weight subjects. Serum levels of vaspin and RBP-4 were not correlated with MHS. Furthermore, a significant positive correlation was observed between circulating omentin-1 and body mass index (BMI) as well as fat percentage (P = 0.02) in the MHS group. Serum vaspin concentrations were not related to body composition components in both groups. In addition, in the MHS group, circulating RBP-4 was positively correlated with fat percentage and fat mass (FM) (p < 0.0001) and was negatively correlated with fat-free mass (FFM) and total body water (TBW) (p < 0.0001). In contrast, in the metabolically unhealthy group, RBP-4 was negatively correlated with fat percentage, FM, and BMI (p < 0.0001) and was positively correlated with FFM and TBW (p < 0.0001).

Conclusions

This study showed that circulating levels of omentin-1 are useful predictors of metabolic health status in overweight and obese people.

Omentin-1; vaspin; RBP-4; obesity; body composition

				Participants

	Total (n = 350)	NWMH (n = 53)	NWMUH (n = 21)	OWMH (n = 37)	OWMUH (n = 71)	MHO (n = 37)	MUHO (n = 131)
Age (year)	36.70 ± 11.62	32.08 ± 12.52	27.77 ± 5.80	34.93 ± 10.39	37.96 ± 10.26	42.12 ± 12.47	38.26 ± 11.67
Height (cm)	161.80 ± 7.89	163.13 ± 7.86	163.11 ± 7.73	162.37 ± 6.45	162.61 ± 8.48	158.31 ± 5.62	161.45 ± 8.48
Weight (kg)	78.08 ± 16.66	56.98 ± 7.43	61.28 ± 8.09	72.47 ± 6.08	73.01 ± 7.08	85.61 ± 13.69	91.48 ± 13.44
BMI (kg/m²)	29.93 ± 6.18	21.39 ± 1.97	22.97 ± 1.68	27.47 ± 1.38	27.60 ± 1.50	34.03 ± 3.89	35.27 ± 4.35
FBS (mmol/L)	5.44 ± 1.38	4.64 ± 0.75	4.85 ± 0.38	5.50 ± 0.87	5.53 ± 0.79	4.89 ± 0.57	5.94 ± 1.91
Insulin (µIU/mL)	11.70 ± 6.42	6.29 ± 2.68	11.31 ± 6.39	8.23 ± 3.42	12.04 ± 7.39	10.73 ± 5.10	15.00 ± 5.10
HOMA-IR	2.82 ± 0.39	1.29 ± 0.09	2.43 ± 0.11	2.01 ± 0.13	2.95 ± 0.26	2.33 ± 0.13	3.96 ± 0.43
Triglyceride (mmol/L)	1.34 ± 0.58	0.89 ± 0.26	1.10 ± 0.46	1.01 ± 0.25	1.55 ± 0.60	1.05 ± 0.32	1.62 ± 0.60
TC (mmol/L)	4.61 ± 0.89	3.87 ± 0.68	4.84 ± 0.56	4.13 ± 0.66	4.90 ± 0.86	4.46 ± 0.97	4.90 ± 0.85
HDL (mmol/L)	1.19 ± 0.29	1.15 ± 0.26	1.10 ± 0.15	1.31 ± 0.27	1.06 ± 0.28	1.45 ± 0.36	1.17 ± 0.25
LDL (mmol/L)	2.57 ± 0.64	2.03 ± 0.38	2.82 ± 0.50	2.19 ± 0.48	2.89 ± 0.65	2.31 ± 0.56	2.77 ± 0.60
hs-CRP (mg/L)	3.10 ± 4.62	0.92±1.01	1.31 ± 1.84	1.00 ± 0.97	2.17 ± 1.89	1.96 ± 2.61	5.68 ± 6.43
Fat percentage (%)	35.14 ± 8.99	23.58 ± 6.47	27.03 ± 5.72	32.19 ± 4.24	33.48 ± 6.91	40.38 ± 6.48	41.35 ± 6.24
Fat mass (kg)	28.30 ± 11.60	13.37 ± 3.98	16.90 ± 5.62	23.29 ± 3.47	24.24 ± 5.02	35.01 ± 9.91	37.85 ± 8.64
FFM (kg)	49.79 ± 9.04	43.63 ± 7.87	44.40 ± 3.26	49.18 ± 5.76	48.78 ± 8.85	50.61 ± 6.49	53.61 ± 9.83
TBW (kg)	36.44 ± 6.62	31.93 ± 5.76	32.51 ± 2.38	36.00 ± 4.21	35.70 ± 6.48	37.03 ± 4.75	39.24 ± 7.20
Visceral fat (kg)	7.25 ± 3.79	2.63 ± 1.91	2.44 ± 1.33	5.56 ± 1.75	6.16 ± 2.03	9.25 ± 2.54	10.29 ± 2.84

Adipokines				Participants

	Total (n = 350)	NWMH (n = 53)	NWMUH (n = 21)	OWMH (n = 37)	OWMUH (n = 71)	MHO (n = 37)	MUHO (n = 131)
Omentin-1 (ng/mL)	336.5 ± 148.7	250.9 ± 169.3^a,b	270.9 ± 230.9^c	282.2 ± 127.5^d,e	415.7 ± 123.7^c,e,f,b	294.4 ± 151.4^f	362 ± 121.7^d,a
Vaspin (µg/L)	1.01 ± 1.42	0.98 ± 1.46	1.45 ± 2.23	0.61 ± 0.52	1.01 ± 1.80	0.81 ± 0.91	1.11 ± 1.35
RBP-4 (µg/mL)	58.97 ± 5.77	65.99 ± 0.66	68.93 ± 0.76	55.23 ± 14.17	59.95 ± 3.57	58.75 ± 2.84	59.20 ± 2.33

	MH group (n = 127)			MUH group (n = 223)

	Omentin-1	Vaspin	RBP-4	Omentin-1	Vaspin	RBP-4
hs-CRP	0.19 (0.17)	-0.02 (0.84)	0.17 (0.42)	-0.01 (0.86)	-0.02 (0.84)	-0.10 (0.41)
BMI	0.31 (0.02)	-0.02 (0.79)	0.38 (0.07)	-0.05 (0.62)	-0.02 (0.79)	-0.43 (< 0.0001)
Fat percentage	0.32 (0.02)	0.04 (0.64)	0.68 (< 0.0001)	-0.09 (0.35)	0.04 (0.64)	-0.48 (< 0.0001)
Fat mass	0.26 (0.07)	0.06 (0.53)	0.74 (< 0.0001)	-0.09 (0.37)	0.06 (0.53)	-0.45 (< 0.0001)
FFM	-0.26 (0.07)	-0.06 (0.55)	-0.74 (< 0.0001)	0.09 (0.37)	-0.06 (0.55)	0.45 (< 0.0001)
TBW	-0.26 (0.07)	-0.06 (0.55)	-0.74 (< 0.0001)	0.09 (0.37)	-0.06 (0.55)	0.45 (< 0.0001)
Visceral fat	0.26 (0.07)	-0.0 (0.91)	-0.05 (0.81)	-0.11 (0.30)	-0.01 (0.91)	-0.10 (0.43)

	Crude			Adjusted^‡

Adipokine	OR	95% CI for OR	P value	OR	95% CI for OR	P value
Omentin-1	1.43	1.02 to 1.07	< 0.0001	1.43	1.01 to 1.07	0.001
Vaspin	1.17	0.88 to1.56	0.25	1.18	0.87 to 1.61	0.27
RBP-4	1.04	0.96 to 1.14	0.28	1.08	0.97 to 1.20	0.12

Weight	Adipokine	OR	95% CI for OR	p-value	P-value^‡
Normal weight (n = 74)	Omentin-1	1.002	0.99 to 1.00	0.37	0.30
	Vaspin	1.11	0.71 to 1.74	0.63	0.42
	Rbp4	1.08	0.92 to 1.27	0.33	0.38
Overweight (n = 108)	Omentin-1	1.81	1.00 to 1.91	0.01	0.01
	Vaspin	1.28	0.70 to 2.33	0.41	0.48
	Rbp4	1.08	0.92 to 1.26	0.33	0.39
Obese (n = 168)	Omentin-1	1.63	1.00 to 1.75	0.06	0.07
	Vaspin	1.29	0.69 to 2.42	0.41	0.78
	Rbp4	1.12	0.81 to 1.54	0.47	0.56

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[1] Correspondence to: Khadijeh Mirzaei. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran P.O. Box: 14155-6117, Tehran, Iran. mirzaei_kh@tums.ac.ir