ABSTRACT
BACKGROUND:
Ostomy is a surgical procedure that creates a stoma that aims to construct a new path for the output of feces or urine. The relationship of oxidative stress (OxS) markers in patients with ostomy is still poorly described.
OBJECTIVE:
The present study was aimed at investigating the changes in oxidative stress parameters in peripheral blood collected from ostomy patients when compared with a healthy control group.
METHODS:
It was evaluated 29 ostomy patients and 30 healthy control patients. The oxidative stress parameters evaluated were: lipid peroxidation [lipid hydroperoxide (LPO), 8-isoprostane (8-ISO) and 4-hydroxynonenal (4-HNE)], protein oxidation and nitration [carbonyl and 3-nitrotyrosine (3-NT)] and DNA oxidation [8-hydroxy-2’-deoxyguanosine (8-OHDG)] in serum from ostomy patients compared to health controls.
RESULTS:
The data showed an increase of LPO, 8-ISO, 4-HNE, 3-NT and 8-OHDG in serum collected from ostomy patients when compared to healthy controls.
CONCLUSION:
The findings support the hypothesis that ostomy triggers the oxidative stress observed in the blood collected from these patients.
HEADINGS:
Surgical stomas, adverse effects; Oxidative stress; Lipid peroxidation; Nitration
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