Håkansson, 20152828. Håkansson B, Montgomery M, Cadiere GB, Rajan A, Bruley des Varannes S, Lerhun M, et al. Randomized clinical trial: Transoral incisionless fundoplication vs. sham intervention to control chronic GERD. Aliment Pharmacol Ther . 2015;42:1261-70.
|
Chronic GERD: 44 |
TIF2: 22 |
sham: 22 |
Time in remission |
6 |
ITT |
Hunter, 20152929. Hunter JG, Kahrilas PJ, Bell RCW, Wilson EB, Trad KS, Dolan JP, et al. Efficacy of transoral fundoplication vs omeprazole for treatment of regurgitation in a randomized controlled trial. Gastroenterology. 2015;148:324-33.
|
Chronic GERD: 129 |
TIF2/placebo: 87 |
sham + PPI: 42 |
ETSR |
6 |
ITT |
Rinsma, 20153030. Rinsma NF, Farré R, Bouvy ND, Masclee AAM, Conchillo JM. The effect of endoscopic fundoplication and proton pump inhibitors on baseline impedance and heartburn severity in GERD patients. Neurogastroenterol Motil. 2015;27:220-8.
|
Chronic GERD: 47 |
TIF2: 32 |
PPI: 15 |
GERD HRQL score |
6 |
ITT |
Witteman, 20153131. Witteman BPL, Conchillo JM, Rinsma NF, Betzel B, Peeters A, Koek GH, et al. Randomized controlled trial of transoral incisionless fundoplication vs. proton pump inhibitors for treatment of gastroesophageal reflux disease. Am J Gastroenterol . 2015;110:531-42.
|
Chronic GERD: 60 |
TIF2: 40 |
PPI: 20 |
>50% GERD HRQL |
6 |
PP |
Trad, 20153232. Trad KS, Barnes WE, Simoni G, Shughoury AB, Mavrelis PG, Raza M, et al. Transoral incisionless fundoplication effective in eliminating GERD symptoms in partial responders to proton pump inhibitor therapy at 6 months. Surg Innov. 2015;22:26-40.
|
Chronic GERD: 63 |
TIF2: 40 |
PPI: 23 |
ETSR |
6 |
PP |
Kaindlstorfer, 20133333. Kaindlstorfer A, Koch OO, Antoniou SA, Asche K-U, Granderath FA, Pointner R. A randomized trial on endoscopic full-thickness gastroplication versus laparoscopic antireflux surgery in GERD patients without hiatal hernias. Surg Laparosc Endosc Percutan Tech. 2013;23:212-22.
|
Chronic GERD: 70 |
NDO surgical: 37 |
LARS: 33 |
DeMeester score |
3 |
ITT |
Corley, 20033434. Corley DA, Katz P, Wo JM, Stefan A, Patti M, Rothstein R, et al. Improvement of gastroesophageal reflux symptoms after radiofrequency energy: a randomized, sham-controlled trial. Gastroenterology. 2003;125:668-76.
|
Chronic GERD: 64 |
Stretta: 35 |
sham 29 |
>50% GERD HRQL |
6 |
PP |
Arts, 20113535. Arts J, Bisschops R, Blondeau K, Farré R, Vos R, Holvoet L, et al. A double-blind sham-controlled study of the effect of radiofrequency energy on symptoms and distensibility of the gastro-esophageal junction in GERD. Am J Gastroenterol . 2012;107:222-30.
|
Chronic GERD: 22 |
Stretta: 11 |
sham: 11 |
GERD HRQL score |
3 |
ITT |
Antoniou, 20123636. Antoniou SA, Koch OO, Kaindlstorfer A, Asche KU, Berger J, Granderath FA, et al. Endoscopic full-thickness plication versus laparoscopic fundoplication: a prospective study on quality of life and symptom control. Surg Endosc . 2012;26:1063-8.
|
Chronic GERD: 60 |
NDO surgical: 30 |
LARS: 30 |
GERD HRQL score |
3-12 |
PP |
Schwartz, 20073737. Schwartz MP, Wellink H, Gooszen HG, Conchillo JM, Samsom M, Smout. Endoscopic gastroplication for the treatment of gastro-oesophageal reflux disease: a randomised, sham-controlled trial. Gut. 2007;56:20-8.
|
Chronic GERD: 60 |
Endocinch: 20 |
sham: 20 |
ETSR |
3 |
ITT |
|
|
|
Observation: 20 |
|
|
|
Fockens, 20103838. Focken P, Cohen L, Edmundowicz SA, Binmoeller K, Rothstein RI, Smith D, et al. Prospective randomized controlled trial of an injectable esophageal prosthesis versus a sham procedure for endoscopic treatment of gastroesophageal reflux disease. Surg Endosc Other Interv Tech . 2010;24:1387-97.
|
Chronic GERD: 118 |
Gate Keeper: 75 |
sham: 43 |
GERD HRQL score |
6 |
PP |
Devière, 20053939. Devière J, Costamagna G, Neuhaus H, Voderholzer W, Louis H, Tringali A, et al. Nonresorbable copolymer implantation for gastroesophageal reflux disease: A randomized sham-controlled multicenter trial. Gastroenterology. 2005;128:532-40.
|
Chronic GERD: 64 |
Enteryx: 32 |
sham: 32 |
>50% GERD HRQL |
3 |
ITT |
Rothstein, 20064040. Rothstein R, Filipi C, Caca K, Pruitt R, Mergener K, Torquati A, et al. Endoscopic full-thickness plication for the treatment of gastroesophageal reflux disease: a randomized, sham-controlled trial. Gastroenterology. 2006;131:704-12.
|
Chronic GERD: 159 |
NDO surgical: 78 |
sham: 81 |
>50% GERD HRQL |
3 |
ITT |
Coron, 20084141. Coron E, Sebille V, Cadiot G, Zerbib F, Ducrotte P, Ducrot F, et al. Clinical trial: Radiofrequency energy delivery in proton pump inhibitor-dependent gastro-oesophageal reflux disease patients. Aliment Pharmacol Ther . 2008;28:1147-58.
|
Chronic GERD: 43 |
Stretta: 23 |
PPI: 20 |
Time in remission |
6-12 |
ITT |
Montgomery, 20064242. Montgomery M, Håkanson B, Ljungqvist O, Ahlman B, Thorell A. Twelve months’ follow-up after treatment with the EndoCinch endoscopic technique for gastro-oesophageal reflux disease: A randomized, placebo-controlled study. Scand J Gastroenterol. 2006;41:1382-9.
|
Chronic GERD: 46 |
Endocinch: 22 |
sham: 24 |
Time in remission |
3 |
ITT |
Aziz, 20104343. Abdel Aziz AM, El-Khayat HR, Sadek A, Mattar SG, McNulty G, Kongkam P, et al. A prospective randomized trial of sham, single-dose Stretta, and double-dose Stretta for the treatment of gastroesophageal reflux disease. Surg Endosc Other Interv Tech . 2010;24:818-25.
|
Chronic GERD: 36 |
Stretta: 12 |
sham: 12 |
Time in remission |
12 |
ITT |
|
|
|
Observation:12 |
|
|
|