Invasive medullary thymoma associated with myasthenia gravis: an unusual case

Miastenia gravis em um paciente com timoma medular invasivo: relato de caso

Abstracts

Thymomas are tumors characterized by a remarkable morphological heterogeneity and variable clinical behavior. This tumor has unique clinical associations, most notably with hematological abnormalities and myasthenia gravis. According with the Müller-Hermelink criteria, there are significant differences between the histological types of thymomas and the association with myasthenia gravis. Among the different histological types, medullary thymoma is the least frequent variant associated with this autoimmune disease. In this report we describe a case of medullary thymoma presenting in a 71-year- old woman with a myasthenic syndrome.

medullary thymoma; myasthenia gravis; immunohistochemistry; Müller-Hermelink classification