Report of a case of cryptococcosis of central nervous system the diagnosis being established by cerebrospinal fluid examination. Direct evidence of Cryptococcus was comproved by cultures. The patient, a white man, 29 years old, presented meningeal symptoms with late association of diffuse encephalic disturbances and intracranial hypertension. The course (4 months) was fatal; sulphamidic therapy was tried with no results. Necroscopic findings confirmed diffuse leptomeningitis, disseminated microabscesses of cerebral cortex; death was related to the presence of medullar compression by herniation of cerebellar tonsyles.