Abstract
This paper has presented a brief review of the treatment of parkinsonism with levodopa. Although there are problems in the utilization of this amino acid in practical therapy, significant amelioration of the symptoms and signs of parkinsonism can be obtained and sustained over long periods of time. It is as yet too early to detect any potential of alteration in the basic progressive course of the disease.
Levodopa and relief of parkinsonian symptons
Richard P. Schmidt; M. D. Melvin Greer, M. D.
University of Florida College of Medicine and the Gainesville Veterans Administration Hospital, Gainesville, Florida, U.S.A.
SUMMARY
This paper has presented a brief review of the treatment of parkinsonism with levodopa. Although there are problems in the utilization of this amino acid in practical therapy, significant amelioration of the symptoms and signs of parkinsonism can be obtained and sustained over long periods of time. It is as yet too early to detect any potential of alteration in the basic progressive course of the disease.
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- 1. ANDEN, N. E.; CARLSSON, A.; DAHLSTROM, A.; FAXE, K.; HILLARP, N. A. & LARSSON, K. Demonstration and mapping out of nigro-neostriatal dopamine neurons. Life Sci. 3:523, 1964.
- 2. BARBEAU, A.; MURPHY, G. F. & SOURKES, T. L. Excretion of dopamine in diseases of basal ganglia. Science 133:1706, 1961.
- 3. CALNE, D. B.; STERN, G. M.; LAURENCE, D. R.; SHARKEY, J. & ARMITAGE, P. L-dopa in postencephalitic parkinsonism. Lancet 1:744, 1969.
- 4. COTZIAS, G. C. Wartenberg Lecture delivered at 1970 aanual meeting, American Academy of Neurology, May 1970.
- 5. COTZIAS, G. C.; PAPAVASILIOU, P. S. & GELLEN, R. Modification of parkinsonism-chronic treatment with L-dopa. New Eng. J. Med. 280:237, 1969.
- 6. COTZIAS, G. C.; VAN WOERT, M. H. & SCHIFFER, L. M. Aromatic amino acids and modification of parkinsonism. New Eng. J. Med. 276:374, 1967.
- 7. EHRINGER, H. & HORNYKIEWICZ, O. Verteilung von Noradrenalin und Dopamine (3-Hydroxytyramine) im Gehirn des Menschen und ihr Verhalten bei Erkrankungen des Extrapyrimivalien Systems. Klin Wschr 38:1236, 1960.
- 8. FALCK, B. Observations on the possibilities of the cellular localization of monoamines by a fluorescence method. Acta Physiol. Scand. 56, Suppl. 197:1-26, 1962.
- 9. FEHLING, C. Treatment of Parkinson's disease with L-dopa. A double blind study. Acta Neurol. Scand. 42:367, 1966.
- 10. GODWIN-AUSTEN, R. B.; TOMLINSON, E. B.; FREARS, C. C. & KOK, H. W. Effects of L-dopa in Parkinson's disease. Lancet 2:165, 1969.
- 11. GREER, M. & WILLIAMS, C. M. Dopamine metabolism in Parkinson's disease. Neurology (Minneapolis) 13:73, 1963.
- 12. HORNYKIEWICZ, O. Der Topische Lokalisation und das Verhalten von Noradrenalin und Dopamine (3-hydroxytyramine) in der substancia nigro des normalin und Parkinsonkranken Menschen. Wien klin Wschr. 75:309, 1963.
- 13. McGEER, P. L. & ZELDOWICZ, L. R. Administration of dihydroxyphenylalamine to parkinsonian patients. Canad. Med. Ass. J. 96:463, 1964.
- 14. MCDOWELL, F.; LEE, J. E.; SWIFT, T.; SWEET, R. D.; OGSBURY, J. S. & KESSLER, J. T. Treatment of Parkinson's syndrome with L-dihydroxyphenylalanine (Levodopa). Ann. Int. Med. 72:29, 1970.
- 15. SANO, I.; SANO, T.; KAKIMOTO, Y.; TANIGUCHI, K.; TAKESADA, M. & NISHINUMA, K. Distribution of catechol compounds in human brain. Biochem. Biophys. Acta 32:586, 1959.
- 16. YAHR, M. D.; DUVOISIN, R. C.; HOEHN, M. M.; SCHEAR, M. J. & BARRETT, R. E. L-Dopa (L-3, 4-dihydroxyphenylalanine) Its clinical effects in parkinsonism. Trans. Amer. Neurol. Ass. 93:56, 1968.
Publication Dates
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Publication in this collection
19 Apr 2013 -
Date of issue
Mar 1971
