THESES
Metabolic profile analysis and anthropometric evaluation in patients with ischemic stroke, diabetic and non-diabetic (Abstract) * Análise do perfil metabólico e avaliação antropométrica em pacientes com acidente vascular cerebral isquêmico, diabéticos e não diabéticos (Resumo). Dissertação de Mestrado, Universidade Federal da Paraíba (Área: Nutrição Clínica). Orientadora: Rosália Gouveia Filizola. ** Address: Rua Santos Coelho Neto 200/802,58038-450 João Pessoa PB, Brasil. E- mail: maurus@zaitek.com.br * * Análise do perfil metabólico e avaliação antropométrica em pacientes com acidente vascular cerebral isquêmico, diabéticos e não diabéticos (Resumo). Dissertação de Mestrado, Universidade Federal da Paraíba (Área: Nutrição Clínica). Orientadora: Rosália Gouveia Filizola. ** Address: Rua Santos Coelho Neto 200/802,58038-450 João Pessoa PB, Brasil. E- mail: maurus@zaitek.com.br . Dissertation. João Pessoa, 2003.
Maurus Marques de Almeida Holanda** * Análise do perfil metabólico e avaliação antropométrica em pacientes com acidente vascular cerebral isquêmico, diabéticos e não diabéticos (Resumo). Dissertação de Mestrado, Universidade Federal da Paraíba (Área: Nutrição Clínica). Orientadora: Rosália Gouveia Filizola. ** Address: Rua Santos Coelho Neto 200/802,58038-450 João Pessoa PB, Brasil. E- mail: maurus@zaitek.com.br
Strokes are one of the most common causes of mortality and long term severe disability.Its incidence increases with age and is somewhat higher in men than in woman and in blacks than in whites. Risk factors for stroke include age, gender,diabetes mellitus (DM), systolic and diastolic hypertension, impaired glucose tolerance, hyperuricemia, smoking, family history of ischemic heart disease (IHD), history of hyperlipidemia, Lp(a), total cholesterol LDL and HDL-cholesterol, triglyceride, apoA-I, B and many others. Despite its importance as a leading cause of disability and death, the incidence of stroke has decreased in recent decades, largely because of improved treament of the modified risk factors.
The aim of this study was to evaluate Lp(a), total cholesterol, HDL, LDL, VLDL cholesterol, triglycerides, apo A and apo B100, uric acid, fibrinogen, T4 and TSH, glycaemic and insulin plasmatic concentrations, obesity and hypertension in patients affected by acute ischemic stroke.
In this group of patients, we have compared the variables between type 2 diabetic patients and non-diabetic patients.We evaluate in this study a total of 60 patients, devided into two groups: 34 non-diabetic patients (22 males and 12 females; mean age 66.71 ± 10.83 years) and a group of 26 type 2 diabetic subjects (15 males and 11 females; mean age 66.35 ± 9.92 years).
A relationship existed between obesity, hypertension and the groups. The waist-hip ratio (WHR) was similar comparing the groups. The mean of lipids concentration did not significantly differ between type 2 diabetic patients and non-diabetic subjects. The distribution of Lp(a) levels was highly skewed towards the higher levels in both groups, being over 30 mg/dl in 50%. Lp(a) concentration was positively correlated with abdominal adiposity, using WHR (p< 0.05). No association was found between Lp(a) and sex, age, other lipidic parameters and the presence of stroke .
Our results show that serum Lp(a) levels are increased in patients with cerebrovascular disease but there were no significant differences between diabetic and non-diabetic patients, which indicates that elevated Lp(a) levels are specifically associated with ischemic stroke but not with type 2 DM. Stroke places a tremendous burden on health resources throughout the world. Improved detection and modification of risk factors could reduce the impact of this disease, and the hipertension with DM, when together, needs to be hardly controled.
Key words: stroke, diabetes mellitus, cerebral thrombosis, arterial hypertension, risk factors.
Publication Dates
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Publication in this collection
19 Sept 2003 -
Date of issue
Sept 2003
