Cruz Gómez et al.38
|
Correlation between brain atrophy and fatigue |
60 |
Fatigue measured by fatigue severity scale |
Segmental atrophy by VBM-SPM8 |
In patients with fatigue there was a reduction in segmentary gray and white matter volume when compared to controls. |
Amato et al.39
|
Evaluate the relationship between cognitive reserve and brain atrophy in patients with RRMS |
52 |
Cognitive reserve was assessed through a score that included education, IQ and pre morbid activities |
Segmental brain volumes and longitudinal PBVC changes (SIENAX and SIENA) |
The cognitive reserve might compensate structural damage, however, with damage and atrophy progression, this compensation is lost. |
Batista et al.40
|
Determine if atrophy of the thalamus and basal ganglia play a role in the speed to process information in RRMS (SPI) |
86 |
Complete neuropsychologic tests, PASAT and SDMT. |
Segmentary subcortical subglobal volumes (SIENAX and FIRST) |
Information processing alterations was related to greater atrophy of subcortical structures that include the thalamus and the caudate. |
Calabrese et al.41
|
Evaluate if atrophy of cortical and deep gray matter structures relates to fatigue in patients with RRMS |
152 |
Fatigue measured by the fatigue impact scale |
Segmental subcortical volumes (FreeSurfer) |
Segmental atrophies were related to greater fatigue in RRMS. |
Pellicano et al.42
|
Assess the correlation between cortical and subcortical regional atrophy in RRMS. |
24 |
Fatige measured by the fatigue impact scale |
Cortical and subcortical segmental brain atrophy (FreeSurfer) |
Parietal cortex atrophy was significantly related to fatigue in patients with RRMS |
Sumowski et al.43
|
Evaluate the effect of brain atrophy on the cognitive reserve |
38 |
Information processing |
Third ventricle enlargement (manual processing) |
Brain atrophy showed negative effects on information processing that was partially attenuated by the cognitive reserve. |
Mineev et al.44
|
Assess correlation between cognitive deterioration and brain atrophy |
65 |
Extended neuropsychologic assessment |
Manually measured brain volumes |
Greater brain atrophy correlated with greater cognitive involvement in patients with RRMS |
Sanchez et al.45
|
Evaluate the correlation between brain atrophy and cognitive deterioration in RRMS |
52 |
Extended neuropsychologic assessment. |
Subcortical global and segmental atrophy (manual processing of the bicaudate space and of the third ventricle diameter) |
Central ventricle atrophy was the best predictor for global cognitive deterioration in this group of patients with RRMS. |
Houtchens et al.46
|
Assess if thalamic atrophy correlates with cognitive deterioration in RRMS |
79 |
Extended neuropsychologic assessment. |
BPF and subcortical brain volumes using JIM software |
Thalamic atrophy might be a sensitive biomarker of neurodegeneration and cognitive impact |
Tekok-Kilic et al.47
|
Evaluate the correlation between gray matter atrophy and cognitive involvement in RRMS |
59 |
Extended neuropsychologic assessment. |
Brain segmental volumetry (SABRE software) |
Thalamic atrophy might be a sensitive biomarker of neurodegeneration and cognitive impact |
Tedeschi et al.48
|
Assess the correlation of fatigue with white and gray matter atrophy |
222 |
Fatige measured by the fatigue impact scale |
Brain total and segmental volumes |
Greater fatigue was observed with greater brain atrophy. |
Sanfilipo et al.49
|
Evaluate correlation of gray and white matter atrophy with cognitive deterioration in RRMS |
40 |
Extended neuropsychologic assessment |
Cortical and subcortical brain total and segmental volumes (SPM99) |
Gray and white matter atrophy contribute independently to cognitive deterioration in RRMS |
Lazeron et al.50
|
Assess the correlation between brain atrophy and cognitive deterioration in RRMS |
82 |
Rao short battery tests |
Segmental and total brain volume (BPF local software) |
Cognitive deterioration in MS depends moderately on brain structural damage. |
Edwards et al.51
|
Evaluate the association between cognitive deterioration and supra – tentorial brain atrophy. |
40 |
Extended neuropsychologic assessment |
Segmental and total brain volume (BPF) |
White matter atrophy correlated with worse cognitive performance, probably reflecting the effect of axonal subcortical damage and myelin loss. |
Zivadinov et al.52
|
Evaluate if cognitive deterioration in early stages of MS correlates with brain volume loss |
53 in early disease stages |
Extended neuropsychologic assessment |
Total brain volume (semiautomatic local program) |
In early stages of the disease, cognitive deterioration correlated signifcantly with total brain volume loss probably due to axonal loss. |