Magnetic resonance imaging in HTLV-I associated myelopathy

Melo, Aílton; Moura, Luciana; Rios, Solana; Machado, Marcos; Costa, Gersonita

doi:10.1590/S0004-282X1993000300006

Abstracts

Magnetic resonance imaging of the brain and spinal cord were carried out for seventeen consecutive patients with HTLV-1 associated myelopathy (HAM). Eight patients had brain abnormalities and four had decreased thoracic spinal cord diameter. Brain lesions were mostly located in subcortical and periventricular areas. Our data suggest that diffuse central nervous system lesions are present in patients with HAM.

HTLV-1; myelopathy; leukoencephalopathy; MRI

Foram realizados exames de ressonância magnética do crânio e coluna em 17 pacientes com diagnóstico clínico e laboratorial de mielopatia por HTLV-1 (HAM). Em oito pacientes havia anormalidades cerebrais caracterizadas por lesões subcorticais e periventriculares. Quatro pacientes apresentavam diminuição acentuada do diâmetro da medula espinal torácica. Nossos dados sugerem ser a HAM uma patologia multifocal que envolve todo o sistema nervoso central.

HTLV-1; mielopatia; leucoencefalopatia; ressonância magnética

Aílton Melo^I; Luciana Moura^II; Solana Rios^I; Marcos Machado^III; Gersonita Costa^III

^IFederal University of Bahia (UFBA) and Santo Antonio Hospital

^IIUFBA

^IIISão Rafael Hospital - Salvador

SUMMARY

Magnetic resonance imaging of the brain and spinal cord were carried out for seventeen consecutive patients with HTLV-1 associated myelopathy (HAM). Eight patients had brain abnormalities and four had decreased thoracic spinal cord diameter. Brain lesions were mostly located in subcortical and periventricular areas. Our data suggest that diffuse central nervous system lesions are present in patients with HAM.

Key words: HTLV-1, myelopathy, leukoencephalopathy, MRI.

RESUMO

Foram realizados exames de ressonância magnética do crânio e coluna em 17 pacientes com diagnóstico clínico e laboratorial de mielopatia por HTLV-1 (HAM). Em oito pacientes havia anormalidades cerebrais caracterizadas por lesões subcorticais e periventriculares. Quatro pacientes apresentavam diminuição acentuada do diâmetro da medula espinal torácica. Nossos dados sugerem ser a HAM uma patologia multifocal que envolve todo o sistema nervoso central.

Palavras-chave: HTLV-1, mielopatia, leucoencefalopatia, ressonância magnética.

Full text available only in PDF format.

Texto completo disponível apenas em PDF.

Aceite: 24-janeiro-1993.

Dr. Ailton Melo Departamento de Neuropsiquiatria, Faculdade de Medicina, UFBA - Av. Reitor Miguel Calmon s/n - 40110-100 Salvador BA - Brasil. Fax 55.71.2458562.

¹
Akizuki S, Nakaaato O, Higuchi Y, Tanabe K, Setohuchi M, Yoshida S, Miyazaki Y, Ymamoto S, Sudou S, Sannomiya K, Okajima T. Necropsy findings in HTLV-1 associated myelopathy. Lancet 1987, 1:156-157.
²
Berger J, Tornatore C, Major EO, Bruce J, Shaphak P, Yoshioka M, Hauff S, Sheremata W, Morton GF, Landy H. Relapsing and remitting human immunodeficiency virus associated leukoencephalomyelopathy. Ann Neurol 1992, 31:34-38.
³
Janssen RS, Kaplan JE, Khabbaz RF et al. HTLV-1 associated myelopathy/tropical spastic paraparesis in the United States. Neurology 1991, 41:1355-1357.
⁴
Karpas A, Kampf V, Siden A, Koch M, Poser S. Lack of evidence for involvement of known human retroviruses in multiple sclerosis. Nature 1986, 322:177-178.
⁵
Kobari M, Meyer JS, Ichijo M, Oravez WT. Leukoaraiosis correlation of MR and CT findings with blood flow, atrophy and cognition. AJNR 1990, 11:273-281.
⁶
Koprowski H, DeFreitas EC, Harper ME, Sandberg-Wollheim M, Sheremata WA, Robert-Guroff M, Saxinger CW, Wong-Staal F, Gallo RC. Multiple sclerosis and human T-cell lymphotropic retroviruses. Nature 1985, 318:154-160.
⁷
Meireles A, Moreira ED, Moreno-Carvalho OA, Badaró R, Melo A. HTLV-1 associated myelopathy in Salvador (Northeastern Brazil). Arq Neuropsiquiatr 1992, 50:189-190.
⁸
Newton M, Miller D, Rudge P, Cruickshank K, Dalgleish A, Clayden S, Moseley I. Antibody to human T-lymphotropic virus type 1 in West-Indian-born UK residents with spastic paraparesis. Lancet 1987, 1:415-416.
⁹
Osame M, Janssen RS, Kubota H, Nishitani H, Igata A, Nagataki S, Marl M, Goto I, Shimabukuro H, Khabaz R, Kaplan J. Nationwide survey of HTLV-1 associated myelopathy in Japan: association with blood transfusion. Ann Neurol 1990, 28:50-56.
¹⁰
Roman GC. The neuroepidemiology of tropical spastic paraparesis. Ann Neurol 1988, 23(Suppl):S113-S130.
¹¹
Sheremata WA, Quencer R, Gatti E, Defreitas E, Harper M, Koprowski H. Magnetic resonance imaging of tropical spastic paraplegia. Neurology 1987, 37(Suppl 1):322.
¹²
Swieten JC, Geyskes GG, Derix MMA et al. Hypertension in the elderly is associated with white matter lesions and cognitive decline. Ann Neurol 1991, 30:825-830.

Magnetic resonance imaging in HTLV-I associated myelopathy

Ressonância magnética na mielopatia associada ao HTLV-I

Publication Dates

Publication in this collection
19 Jan 2011
Date of issue
Sept 1993

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] ¹
Akizuki S, Nakaaato O, Higuchi Y, Tanabe K, Setohuchi M, Yoshida S, Miyazaki Y, Ymamoto S, Sudou S, Sannomiya K, Okajima T. Necropsy findings in HTLV-1 associated myelopathy. Lancet 1987, 1:156-157.

[2] ²
Berger J, Tornatore C, Major EO, Bruce J, Shaphak P, Yoshioka M, Hauff S, Sheremata W, Morton GF, Landy H. Relapsing and remitting human immunodeficiency virus associated leukoencephalomyelopathy. Ann Neurol 1992, 31:34-38.

[3] ³
Janssen RS, Kaplan JE, Khabbaz RF et al. HTLV-1 associated myelopathy/tropical spastic paraparesis in the United States. Neurology 1991, 41:1355-1357.

[4] ⁴
Karpas A, Kampf V, Siden A, Koch M, Poser S. Lack of evidence for involvement of known human retroviruses in multiple sclerosis. Nature 1986, 322:177-178.

[5] ⁵
Kobari M, Meyer JS, Ichijo M, Oravez WT. Leukoaraiosis correlation of MR and CT findings with blood flow, atrophy and cognition. AJNR 1990, 11:273-281.

[6] ⁶
Koprowski H, DeFreitas EC, Harper ME, Sandberg-Wollheim M, Sheremata WA, Robert-Guroff M, Saxinger CW, Wong-Staal F, Gallo RC. Multiple sclerosis and human T-cell lymphotropic retroviruses. Nature 1985, 318:154-160.

[7] ⁷
Meireles A, Moreira ED, Moreno-Carvalho OA, Badaró R, Melo A. HTLV-1 associated myelopathy in Salvador (Northeastern Brazil). Arq Neuropsiquiatr 1992, 50:189-190.

[8] ⁸
Newton M, Miller D, Rudge P, Cruickshank K, Dalgleish A, Clayden S, Moseley I. Antibody to human T-lymphotropic virus type 1 in West-Indian-born UK residents with spastic paraparesis. Lancet 1987, 1:415-416.

[9] ⁹
Osame M, Janssen RS, Kubota H, Nishitani H, Igata A, Nagataki S, Marl M, Goto I, Shimabukuro H, Khabaz R, Kaplan J. Nationwide survey of HTLV-1 associated myelopathy in Japan: association with blood transfusion. Ann Neurol 1990, 28:50-56.

[10] ¹⁰
Roman GC. The neuroepidemiology of tropical spastic paraparesis. Ann Neurol 1988, 23(Suppl):S113-S130.

[11] ¹¹
Sheremata WA, Quencer R, Gatti E, Defreitas E, Harper M, Koprowski H. Magnetic resonance imaging of tropical spastic paraplegia. Neurology 1987, 37(Suppl 1):322.

[12] ¹²
Swieten JC, Geyskes GG, Derix MMA et al. Hypertension in the elderly is associated with white matter lesions and cognitive decline. Ann Neurol 1991, 30:825-830.