Aspectos ultra-estruturais da doença de Parkinson

Mattos, James Pitágoras de; Alencar, Alexandre; Silva, Angela Gonçalves da; Fonseca, Maria Evangelina Ferreira

doi:10.1590/S0004-282X1989000400008

Resumos

A análise de cinco encéfalos humanos, quatro de pacientes parkinsonianos e um de controle, pela microscopia eletrônica de transmissão, evidenciou as seguintes mais freqüentes alterações: empobrecimento de fibras nervosas, grande aumento do espaço intersticial, desintegração do neurópilo e tumefação e degeneração das mitocôndrias. Com exceção das alterações mitocondriais, as demais ocorreram em todos os encéfalos dos parkinsonianos, fato não observado no caso controle, o que torna difícil atribuí-las à fixação. Traduzem, em última análise, a perda neuronal crônica. Houve, também, presença de depósitos amorfos no interior das mitocôndrias, dos axônios, do citoplasma e do espaço intersticial.

Brains from four parkinsonian patients and one control patient were analysed by electron microscopy. The most consistent abnormal findings were nerve fibers rarefaction, great interstitial space enlargement, neuropil disruption, mitochondrial tumefaction and degenerative changes. These findings occurred regularly in the brain of parkinsonian patients. Furthermore, except for mitochondrial changes, they were distinctively absent in the control patient, and therefore cannot be attributed to technical problems. Contrarywise, they clearly reflect chronic neuronal loss. Also noteworthy was the demonstrative of deposits of amorphous substance into mitochondria, axons, cytoplasm and into the interstitial space.

Aspectos ultra-estruturais da doença de Parkinson

Ultrastructural aspects of Parkinson's disease

James Pitágoras de Mattos^I; Alexandre Alencar^II; Angela Gonçalves da Silva^III; Maria Evangelina Ferreira Fonseca^IV

^IInstituto de Neurologia Deolindo Couto da Universidade Federal do Rio de Janeiro (UFRJ) e no Departamento de Virologia do Instituto de Microbiologia da UFRJ: Professor Adjunto e Doutor

^IIInstituto de Neurologia Deolindo Couto da Universidade Federal do Rio de Janeiro (UFRJ) e no Departamento de Virologia do Instituto de Microbiologia da UFRJ: Professor Adjunto e Chefe do Laboratório de Neuropatologia do INDC

^IIIInstituto de Neurologia Deolindo Couto da Universidade Federal do Rio de Janeiro (UFRJ) e no Departamento de Virologia do Instituto de Microbiologia da UFRJ: Técnica de nível superior da FINEP

^IVInstituto de Neurologia Deolindo Couto da Universidade Federal do Rio de Janeiro (UFRJ) e no Departamento de Virologia do Instituto de Microbiologia da UFRJ: Professor Adjunto de Microbiologia da UFRJ

RESUMO

A análise de cinco encéfalos humanos, quatro de pacientes parkinsonianos e um de controle, pela microscopia eletrônica de transmissão, evidenciou as seguintes mais freqüentes alterações: empobrecimento de fibras nervosas, grande aumento do espaço intersticial, desintegração do neurópilo e tumefação e degeneração das mitocôndrias. Com exceção das alterações mitocondriais, as demais ocorreram em todos os encéfalos dos parkinsonianos, fato não observado no caso controle, o que torna difícil atribuí-las à fixação. Traduzem, em última análise, a perda neuronal crônica. Houve, também, presença de depósitos amorfos no interior das mitocôndrias, dos axônios, do citoplasma e do espaço intersticial.

SUMMARY

Brains from four parkinsonian patients and one control patient were analysed by electron microscopy. The most consistent abnormal findings were nerve fibers rarefaction, great interstitial space enlargement, neuropil disruption, mitochondrial tumefaction and degenerative changes. These findings occurred regularly in the brain of parkinsonian patients. Furthermore, except for mitochondrial changes, they were distinctively absent in the control patient, and therefore cannot be attributed to technical problems. Contrarywise, they clearly reflect chronic neuronal loss. Also noteworthy was the demonstrative of deposits of amorphous substance into mitochondria, axons, cytoplasm and into the interstitial space.

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Dr. J. Pitágoras de Mattos - Av. São Sebastião 165/101 - 22292 Rio de Janeiro RJ - Brasil.

1. Barbeau A - Etiology of Parkinson's disease: research strategy neurology. Can J Neurol Sci 11: 24, 1984.
2. Barbeau A - Parkinson's disease: etiological considerations. In Yahr, MD (ed): The Basal Ganglia. Raven, New York, 1976, pg 281.
3. Barbeau A - Parkinson's disease: etiological considerations. Res Publ Assoc Res Nerv Ment Dis 55: 281, 1976.
4. Duffy PE, Tennyson VM - Phase and electron microscopic observations of Lewy bodies and melanin granules in the substantia nigra and locus coeruleus in Parkinson's disease. J Neuropath Exp Neurol 24: 398, 1965.
5. Forno LS - Pathology of Parkinson's disease. In Marsden CD, Fahn S (eds): Movement Disorders. Butterworth, London, 1981, pg 25.
6. Forno LS, Norville RL - Ultrastructure of Lewy bodies in the stellate ganglion. Acta Neuropath 34: 183, 1976.
7. Kondo K - Epidemiological clues for the etiology of Parkinson's disease. Adv Neurol 40: 345, 1984.
8. Mann DMA, Yates PO - Pathogenesis of Parkinson's disease. Arch Neurol 39: 545, 1982.
9. Roy S, Wolman L - Ultrastructural observations in the parkinsonism. J Path 99: 39, 1969.
10. Watanabe I, Vachal E, Tomita T - Dense core vesicles around the Lewy body in incidental Parkinson's disease: an electron microscopic study. Acta Neuropath 39: 173, 1977.

Datas de Publicação

Publicação nesta coleção
01 Jun 2011
Data do Fascículo
Dez 1989

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. Barbeau A - Etiology of Parkinson's disease: research strategy neurology. Can J Neurol Sci 11: 24, 1984.

[2] 2. Barbeau A - Parkinson's disease: etiological considerations. In Yahr, MD (ed): The Basal Ganglia. Raven, New York, 1976, pg 281.

[3] 3. Barbeau A - Parkinson's disease: etiological considerations. Res Publ Assoc Res Nerv Ment Dis 55: 281, 1976.

[4] 4. Duffy PE, Tennyson VM - Phase and electron microscopic observations of Lewy bodies and melanin granules in the substantia nigra and locus coeruleus in Parkinson's disease. J Neuropath Exp Neurol 24: 398, 1965.

[5] 5. Forno LS - Pathology of Parkinson's disease. In Marsden CD, Fahn S (eds): Movement Disorders. Butterworth, London, 1981, pg 25.

[6] 6. Forno LS, Norville RL - Ultrastructure of Lewy bodies in the stellate ganglion. Acta Neuropath 34: 183, 1976.

[7] 7. Kondo K - Epidemiological clues for the etiology of Parkinson's disease. Adv Neurol 40: 345, 1984.

[8] 8. Mann DMA, Yates PO - Pathogenesis of Parkinson's disease. Arch Neurol 39: 545, 1982.

[9] 9. Roy S, Wolman L - Ultrastructural observations in the parkinsonism. J Path 99: 39, 1969.

[10] 10. Watanabe I, Vachal E, Tomita T - Dense core vesicles around the Lewy body in incidental Parkinson's disease: an electron microscopic study. Acta Neuropath 39: 173, 1977.