Imunoglobulinas do líquido cefalorraqueano normal: II. Relações e índices

Livramento, J. A.

doi:10.1590/S0004-282X1979000400005

Resumos

Foram estudadas as relações e índices de imunoglobulinas do LCR e soro de 50 pessoas com cefaléia crônica e com LCR normal. As relações estudadas foram: IGG LCR/PT LCR; IGG LCR/A LCR; IGG LCR/PA+A LCR. Os índices estudados foram: (IGG LCR/IGG S)/(A LCR/A S); (IGG LCR/IGG S) / (PA-fA LCR/A S). De acordo com o material estudado, foi verificado que o melhor índice para avaliar o comportamento de IGG visando a estudos sobre a eventual imunoprodução local é o (IGG LCR/IGG S) / (PA+A LCR/A S) representado pela média de 0,56 com desvio padrão de 0,32.

Relations and quocientes of cerebrospinal fluid (CSF) immunoglobulins G (IGG) and serum (S) IGG were studied in 50 patients with chronic headache, normal neurological examination and normal electroencephalogram. CSF was normal as to: pressure, cytology, total proteins, protein fractions and immunoglobulins (IGG, IGA and IGM) contents. In all cases the CSF sample studied was collected from cisterna magna. The relations and quocients studied were: CSF IGG/CSF TOTAL PROTEIN, CSF IGG/CSF ALBUMIN, CSF IGG/CSF PRE ALBUMIN+ALBU-MIN, (CSF IGG/S IGG) / (CSF ALBUMIN/S ALBUMIN) and (CSF IGG/S IGG) / (CSF PRE ALBUMIN+ALBUMIN) / (S ALBUMIN). It was found that the best index to appraise the behavior of IGG is: (CSF IGG/S IGG) / (CSF PRE ALBUMIN-f ALBUMIN/S ALBUMIN) that shows an average of 0.56 and a standard deviation of 0.32 in the material studied.

Imunoglobulinas do liquido cefalorraqueano normal: II. Relações e indices

Cerebrospinal fluid immunoglobulins: relations and quocients

J. A. Livramento

Médico-Assistente. Centro de Investigações em Neurologia da Clínica Neurológica da Faculdade de Medicina da Universidade de Sãa Paulo (Praf. Dr. H. M. Canelas)

RESUMO

Foram estudadas as relações e índices de imunoglobulinas do LCR e soro de 50 pessoas com cefaléia crônica e com LCR normal. As relações estudadas foram: IGG LCR/PT LCR; IGG LCR/A LCR; IGG LCR/PA+A LCR. Os índices estudados foram: (IGG LCR/IGG S)/(A LCR/A S); (IGG LCR/IGG S) / (PA-fA LCR/A S). De acordo com o material estudado, foi verificado que o melhor índice para avaliar o comportamento de IGG visando a estudos sobre a eventual imunoprodução local é o (IGG LCR/IGG S) / (PA+A LCR/A S) representado pela média de 0,56 com desvio padrão de 0,32.

SUMMARY

Relations and quocientes of cerebrospinal fluid (CSF) immunoglobulins G (IGG) and serum (S) IGG were studied in 50 patients with chronic headache, normal neurological examination and normal electroencephalogram. CSF was normal as to: pressure, cytology, total proteins, protein fractions and immunoglobulins (IGG, IGA and IGM) contents. In all cases the CSF sample studied was collected from cisterna magna.

The relations and quocients studied were: CSF IGG/CSF TOTAL PROTEIN, CSF IGG/CSF ALBUMIN, CSF IGG/CSF PRE ALBUMIN+ALBU-MIN, (CSF IGG/S IGG) / (CSF ALBUMIN/S ALBUMIN) and (CSF IGG/S IGG) / (CSF PRE ALBUMIN+ALBUMIN) / (S ALBUMIN).

It was found that the best index to appraise the behavior of IGG is: (CSF IGG/S IGG) / (CSF PRE ALBUMIN-f ALBUMIN/S ALBUMIN) that shows an average of 0.56 and a standard deviation of 0.32 in the material studied.

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Trabalho do Centro de Investigações em Neurologia da Clínica Neurológica da Faculdade de Medicina da Universidade de Sãa Paulo (Praf. Dr. H. M. Canelas).

Centro de Investigações em Neurologia - Faculdade de Medicina, Universidade de São Paulo - Caixa Postal 5199 - 01000 São Paulo, SP - Brasil.

1. BERNER, J. J.; CIEMINS, V. A. & SCHROEDER Jr., E. F. - Radial Immunodiffusion of spinal fluid: diagnostic value in multiple sclerosis. Amer. J. clin. Path. 58:145-152, 1972.
2. BROOKS, R. A. - Quantitation of cerebrospinal fluid proteins. Amer. J. clin. Path. 59:886, 1973.
3. CAZZULLO, C. L.; MONTANINI, R.; PALTRINIERI, E. & GIOVANNUCCI, M. - II comportamento delle immunoglobuline nella sclerosi múltipla. Acta neurol. (Napoli) 23:589-599, 1968.
4. CERRATO, D.; CORRIDORI, F. & NESPOLO, A. - L'immunoliffusione radiale semplice sul liquor: metódica e sue applicazioni. Riv. Patol. nerv. ment. 95:572-578, 1974.
5. EICKHOFF, K.; WIKSTROM, J.; POSER, S. & BAUER, H. - Protein profile of cerebrospinal fluid in multiple sclerosis with special reference to the function of the blood brain barrier. J. Neurol. 214:207-215, 1977.
6. FISCHER-WILLIAMS, M. & ROBERTS, R. C. - Cerebrospinal fluid proteins and serum immunoglobulins. Arch. Neurol. (Chicago) 25:526-534, 1971.
7. GANROT, K. & LAURELL, C. B. - Measurement of IGG and albumin content of cerebrospinal fluid and its interpretation. Clin. Chem. 30:571-573, 1974.
8. HARTLEY, T. F.; MERRILL, D. A. & CLAMAN, H. N. - Quantitation of immunoglobulins in cerebrospinal fluid. Arch. Neurol. (Chicago) 15:472-479, 1966.
9. IRULEGUI-GOMES, I. - Estudo das Proteínas Séricas de Crianças: Eletroforese, Imunoelectroforese, Quantificação das Imunoglobulinas. Tese. Fac. Medicina, Univ. São Paulo, 1972.
10. KABAT, E. A.; FREEDMAN, D. A.; MURRAY, J. P. & KNAUB, V. - A study of the crystalline albumin, gamma globulin and total protein in the cerebrospinal fluid of one hundred cases of multiple sclerosis and in other diseases. Amer. J. med. Sci. 219:55-64, 1950.
11. KABAT, E. A.; GLUSMAN, M. & KNAUB, V. - Quantitative estimation of the albumin and gamma globulin in normal and pathologic cerebrospinal fluid by immunochemical methods. Amer. J. Med. 4:653-662, 1948.
12. KOLAR, O. J.; ROSS, A. T. & GILLIAM, H. - Serum IGG, IGA and IGM concentration in 1,038 patients with various neurological disorders. A. Neurol. 203:133-144, 1972.
13. KOLAR, O. J.; ROSS, A. T. & HERMAN, - Serum and cerebrospinal fluid immunoglobulins in multiple sclerosis. Neurology (Minneap.) 20:1062-1061, 1970.
14. LEBAS, J.; ROUSSEL, P.; BISERTE, G.; ARNOTT, G.; GALLOT, P. & WAROT, P. - Etude electrophorétique et dosage des immunoglobulines du liquide céphalo-rachidien. Lille méd. 22:22-25, 1977.
15. LINK, H. - Characteristics of the immune response within the CNS in neurological disorders. Acta neurol. scand. 57 (suppl. 67): 177-190, 1978.
16. LINK, H. & MÜLLER, R. - Immunoglobulins in multiple sclerosis and infections of the nervous system. Arch. Neurol. (Chicago) 25:326-344, 1971.
17. LINK, H.; PARELIUS, M. & SALMI, A. A. - Measles antibodies and immunoglobulins in serum and cerebrospinal fluid in subacute sclerosing panencephalitis. Acta neurol. scand. 46 (suppl. 43): 385-387, 1972.
18. LINK, H. & TIBBLING, C. - Principles of albumin and IGG analyses in neurological disorders. II. Relation of the concentration of the proteins in serum and cerebrospinal fluid. Scand. J. clin. Lab. Invest. 37:391-396, 1977.
19. LINK, H. & TIBBLING, G. - Principles of albumin and IGG analyses in neurological disorders. III. Evaluation of IGG synthesis within the central nervous system in multiple sclerosis. Scand. J. clin. Bab. Invest. 37:397-401, 1977.
20. LIVRAMENTO, J. A. - Imunoglobulinas do líquido cefalorraqueano normal. Arq. Neuro-Psiquiat. (Sâb Paulo) 37:230-249, 1979.
21. LÖWENTHAL, A. - Agar Electrophoresis in Neurology. Elsevier Publ. Co., Amsterdam, 1965.
22. OLSSON, J. E.; PETTERSSON, B. - A comparison between agar gel electrophoresis and CSF serum quotients of IGG and albumin in neurological diseases. Acta neurol. scand. 53:308-322, 1976.
23. PALTRINIERI, E. - Studio immunoelettroforetico delle proteine sieriche e liquo-rali nella sclerosi múltipla. Acta neurol. (Napoli) 22:216-227, 1967.
24. ROBERTS-THOMSON, P. J.; ESIRI, M. M.; YOUNG, A. C. & MacLENNAN, I. C. M. - Cerebrospinal fluid immunoglobulin quotients, kappa/lambda ratios, and viral antibody titres in neurological disease. J. clin. Path. 29:1105-1115, 1976.
25. SANDBERG-WOLLHEIM, M. - Immunoglobulin synthesis in vitro by cerebrospinal fluid celJs in patients with multiple sclerosis. Scand. J. Immunol. 3:717-730, 1974.
26. SPIN A-FRANÇA, A. - Eletroforese em papel das proteínas do líquido cefalorraqueano. IV. Valores normais. Arq. Neuropsiquiat. (São Paulo) 18:19-28, 1960.
27. SPINA-FRANÇA, A.; LIVRAMENTO, J. A. & BACHESCHI, L. A. - Gama globulinorraquia e o aspecto auto-imune de afecções do sistema nervoso. Resumos. VI Congresso Brasileiro de Neurologia (Rio de Janeiro): 13-15, 1974.
28. TAVOLATO, B. - Sclerosi múltipla: le immunoglobüline dei sistema nervoso cen-trale. Riv. Patol. nerv. ment. 95:363-375, 1974.
29. TAVOLATO, B. & ZANCHE, L. - Le anomalie del precipitato dell'immunoglo-bulina G (IGG) nel liquor. Acta neurol. (Napoli) 23:795-801, 1968.
30. TIBBLENG, G.; LINK, H. & OHMAN, S. - Principles of albumin and IGG analyses in neurological disorders. I. Establishment of reference values. Scand. J. clin. Lab. Invest. 37:385-390, 1977.
31. TOURTELLOTTE, W. W. - On cerebrospinal fluid immunoglobulin G (IGG) quotients in multiple sclerosis and other diseases. J. neurol. Sci. 10:279-304, 1970.
32. TOURTELLOTTE, W. W. ,& PARKER, J. A. - Multiple sclerosis: correlation between immunoglobulin-G in cerebrospinal fluid and brain. Science 154:1044-1045, 1966.
33. TOURTELLOTTE, W. W.; PARKER, J. A.; HERNDON, R. M. & CUADROS, C. V. - Subacute sclerosing panencephalitis: brain immunoglobulin-G, measles antibody and albumin. Neurology (Minneap.) 18:117-121, 1968.
34. TOURTELLOTTE, W. W.; TAVOLATO, B.; PARKER, J. A. & COMISO, P. - Cerebrospinal fluid eletroimmunodiffusion. Arch. Neurol. (Chicago) 25:345-350, 1971.

Datas de Publicação

Publicação nesta coleção
22 Ago 2012
Data do Fascículo
Dez 1979

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. BERNER, J. J.; CIEMINS, V. A. & SCHROEDER Jr., E. F. - Radial Immunodiffusion of spinal fluid: diagnostic value in multiple sclerosis. Amer. J. clin. Path. 58:145-152, 1972.

[2] 2. BROOKS, R. A. - Quantitation of cerebrospinal fluid proteins. Amer. J. clin. Path. 59:886, 1973.

[3] 3. CAZZULLO, C. L.; MONTANINI, R.; PALTRINIERI, E. & GIOVANNUCCI, M. - II comportamento delle immunoglobuline nella sclerosi múltipla. Acta neurol. (Napoli) 23:589-599, 1968.

[4] 4. CERRATO, D.; CORRIDORI, F. & NESPOLO, A. - L'immunoliffusione radiale semplice sul liquor: metódica e sue applicazioni. Riv. Patol. nerv. ment. 95:572-578, 1974.

[5] 5. EICKHOFF, K.; WIKSTROM, J.; POSER, S. & BAUER, H. - Protein profile of cerebrospinal fluid in multiple sclerosis with special reference to the function of the blood brain barrier. J. Neurol. 214:207-215, 1977.

[6] 6. FISCHER-WILLIAMS, M. & ROBERTS, R. C. - Cerebrospinal fluid proteins and serum immunoglobulins. Arch. Neurol. (Chicago) 25:526-534, 1971.

[7] 7. GANROT, K. & LAURELL, C. B. - Measurement of IGG and albumin content of cerebrospinal fluid and its interpretation. Clin. Chem. 30:571-573, 1974.

[8] 8. HARTLEY, T. F.; MERRILL, D. A. & CLAMAN, H. N. - Quantitation of immunoglobulins in cerebrospinal fluid. Arch. Neurol. (Chicago) 15:472-479, 1966.

[9] 9. IRULEGUI-GOMES, I. - Estudo das Proteínas Séricas de Crianças: Eletroforese, Imunoelectroforese, Quantificação das Imunoglobulinas. Tese. Fac. Medicina, Univ. São Paulo, 1972.

[10] 10. KABAT, E. A.; FREEDMAN, D. A.; MURRAY, J. P. & KNAUB, V. - A study of the crystalline albumin, gamma globulin and total protein in the cerebrospinal fluid of one hundred cases of multiple sclerosis and in other diseases. Amer. J. med. Sci. 219:55-64, 1950.

[11] 11. KABAT, E. A.; GLUSMAN, M. & KNAUB, V. - Quantitative estimation of the albumin and gamma globulin in normal and pathologic cerebrospinal fluid by immunochemical methods. Amer. J. Med. 4:653-662, 1948.

[12] 12. KOLAR, O. J.; ROSS, A. T. & GILLIAM, H. - Serum IGG, IGA and IGM concentration in 1,038 patients with various neurological disorders. A. Neurol. 203:133-144, 1972.

[13] 13. KOLAR, O. J.; ROSS, A. T. & HERMAN, - Serum and cerebrospinal fluid immunoglobulins in multiple sclerosis. Neurology (Minneap.) 20:1062-1061, 1970.

[14] 14. LEBAS, J.; ROUSSEL, P.; BISERTE, G.; ARNOTT, G.; GALLOT, P. & WAROT, P. - Etude electrophorétique et dosage des immunoglobulines du liquide céphalo-rachidien. Lille méd. 22:22-25, 1977.

[15] 15. LINK, H. - Characteristics of the immune response within the CNS in neurological disorders. Acta neurol. scand. 57 (suppl. 67): 177-190, 1978.

[16] 16. LINK, H. & MÜLLER, R. - Immunoglobulins in multiple sclerosis and infections of the nervous system. Arch. Neurol. (Chicago) 25:326-344, 1971.

[17] 17. LINK, H.; PARELIUS, M. & SALMI, A. A. - Measles antibodies and immunoglobulins in serum and cerebrospinal fluid in subacute sclerosing panencephalitis. Acta neurol. scand. 46 (suppl. 43): 385-387, 1972.

[18] 18. LINK, H. & TIBBLING, C. - Principles of albumin and IGG analyses in neurological disorders. II. Relation of the concentration of the proteins in serum and cerebrospinal fluid. Scand. J. clin. Lab. Invest. 37:391-396, 1977.

[19] 19. LINK, H. & TIBBLING, G. - Principles of albumin and IGG analyses in neurological disorders. III. Evaluation of IGG synthesis within the central nervous system in multiple sclerosis. Scand. J. clin. Bab. Invest. 37:397-401, 1977.

[20] 20. LIVRAMENTO, J. A. - Imunoglobulinas do líquido cefalorraqueano normal. Arq. Neuro-Psiquiat. (Sâb Paulo) 37:230-249, 1979.

[21] 21. LÖWENTHAL, A. - Agar Electrophoresis in Neurology. Elsevier Publ. Co., Amsterdam, 1965.

[22] 22. OLSSON, J. E.; PETTERSSON, B. - A comparison between agar gel electrophoresis and CSF serum quotients of IGG and albumin in neurological diseases. Acta neurol. scand. 53:308-322, 1976.

[23] 23. PALTRINIERI, E. - Studio immunoelettroforetico delle proteine sieriche e liquo-rali nella sclerosi múltipla. Acta neurol. (Napoli) 22:216-227, 1967.

[24] 24. ROBERTS-THOMSON, P. J.; ESIRI, M. M.; YOUNG, A. C. & MacLENNAN, I. C. M. - Cerebrospinal fluid immunoglobulin quotients, kappa/lambda ratios, and viral antibody titres in neurological disease. J. clin. Path. 29:1105-1115, 1976.

[25] 25. SANDBERG-WOLLHEIM, M. - Immunoglobulin synthesis in vitro by cerebrospinal fluid celJs in patients with multiple sclerosis. Scand. J. Immunol. 3:717-730, 1974.

[26] 26. SPIN A-FRANÇA, A. - Eletroforese em papel das proteínas do líquido cefalorraqueano. IV. Valores normais. Arq. Neuropsiquiat. (São Paulo) 18:19-28, 1960.

[27] 27. SPINA-FRANÇA, A.; LIVRAMENTO, J. A. & BACHESCHI, L. A. - Gama globulinorraquia e o aspecto auto-imune de afecções do sistema nervoso. Resumos. VI Congresso Brasileiro de Neurologia (Rio de Janeiro): 13-15, 1974.

[28] 28. TAVOLATO, B. - Sclerosi múltipla: le immunoglobüline dei sistema nervoso cen-trale. Riv. Patol. nerv. ment. 95:363-375, 1974.

[29] 29. TAVOLATO, B. & ZANCHE, L. - Le anomalie del precipitato dell'immunoglo-bulina G (IGG) nel liquor. Acta neurol. (Napoli) 23:795-801, 1968.

[30] 30. TIBBLENG, G.; LINK, H. & OHMAN, S. - Principles of albumin and IGG analyses in neurological disorders. I. Establishment of reference values. Scand. J. clin. Lab. Invest. 37:385-390, 1977.

[31] 31. TOURTELLOTTE, W. W. - On cerebrospinal fluid immunoglobulin G (IGG) quotients in multiple sclerosis and other diseases. J. neurol. Sci. 10:279-304, 1970.

[32] 32. TOURTELLOTTE, W. W. ,& PARKER, J. A. - Multiple sclerosis: correlation between immunoglobulin-G in cerebrospinal fluid and brain. Science 154:1044-1045, 1966.

[33] 33. TOURTELLOTTE, W. W.; PARKER, J. A.; HERNDON, R. M. & CUADROS, C. V. - Subacute sclerosing panencephalitis: brain immunoglobulin-G, measles antibody and albumin. Neurology (Minneap.) 18:117-121, 1968.

[34] 34. TOURTELLOTTE, W. W.; TAVOLATO, B.; PARKER, J. A. & COMISO, P. - Cerebrospinal fluid eletroimmunodiffusion. Arch. Neurol. (Chicago) 25:345-350, 1971.