Regional cerebral blood flow and cognitive function in patients
          with obsessive-compulsive disorder

Guo, Huirong; Zhao, Ning; Li, Zheng; Zhu, Binhua; Cui, He; Li, Youhui

doi:10.1590/0004-282X20130205

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Articles • Arq. Neuro-Psiquiatr. 72 (1) • Jan 2014 • https://doi.org/10.1590/0004-282X20130205 copy

Regional cerebral blood flow and cognitive function in patients with obsessive-compulsive disorder

Fluxo sanguíneo regional cerebral e função cognitiva em pacientes com transtorno obsessivo compulsivo

Authorship SCIMAGO INSTITUTIONS RANKINGS

Objective:

To explore the relationship between regional cerebral blood flow (CBF) and cognitive function in obsessive-compulsive disorder (OCD).

Method:

Single-photon emission computed tomography (SPECT) was performed for 139 OCD patients and 139 controls, and the radioactivity rate (RAR) was calculated. Cognitive function was assessed by the Wisconsin Card Sorting Test (WCST).

Results:

The RARs of the prefrontal, anterior temporal, and right occipital lobes were higher in patients than controls. For the WCST, correct and classification numbers were significantly lower, and errors and persistent errors were significantly higher in OCD patients. Right prefrontal lobe RAR was negatively correlated with correct numbers, right anterior temporal lobe RAR was positively correlated with errors, and the RARs of the right prefrontal lobe and left thalamus were positively correlated with persistent errors.

Conclusion:

OCD patients showed higher CBF in the prefrontal and anterior temporal lobes, suggesting that these areas may be related with cognitive impairment.

obsessive-compulsive disorder; regional cerebral blood flow; cognitive function

Encephalic region	OCD	Control	t	P
Left prefrontal lobe	94.4±6.1	88.3±7.1^*	6.78	0.001^**
Right prefrontal lobe	99.8±6.4	86.9±7.9^*	11.93	<0.001^**
Left aboral frontal lobe	93.7±6.3	98.6±8.0	-1.14	0.560
Right aboral frontal lobe	96.3±9.4	92.9±9.2	1.62	0.101
Left anterior temporal lobe	91.6±6.1	84.0±7.2^*	7.15	0.002^**
Right anterior temporal lobe	92.8±6.6	84.4±7.3^*	9.40	<0.001^**
Left aboral temporal lobe	94.9±7.5	99.5±9.6	4.64	0.055
Right aboral temporal lobe	92.9±6.6	94.7±8.1	-2.00	0.315
Left cingulate gyrus	92.8±5.4	96.2±7.9	-2.22	0.188
Right cingulate gyrus	93.1±6.1	95.4±8.7	-0.85	0.673
Left parietal lobe	96.1±7.5	93.8±10.9	1.95	0.650
Right parietal lobe	96.0±6.6	92.4±9.4	0.48	0.060
Left occipital lobe	101.9±8.1	97.5±11.2	0.48	0.059
Right occipital lobe	102.3±7.7	96.4±10.2	4.89	0.043^*
Left basal ganglia	85.9±6.9	88.6±4.0	-3.64	0.078
Right basal ganglia	87.5±6.1	89.4±8.9	-2.63	0.201
Left thalamus	80.7±8.8	82.5±9.1	-2.38	0.337
Right thalamus	78.6±8.5	83.4±10.0	-4.01	0.062

Item	OCD	Control	t	P
Scores of corrects	33.24±5.39	38.15±4.64	-3.657	0.006^**
Scores of errors	13.21±6.89	7.53±5.97	5.881	0.000^**
Persistent errors	6.79±4.89	2.06±1.29	4.873	0.001^**
Non-maintained errors	6.49±2.74	5.59±4.41	1.713	0.139
Complete Classification	4.42±1.62	5.72±0.94	-2.595	0.012^*

Encephalic region	Scores of corrects		Scores of errors		Persistent errors		Non-maintained errors		Classification
Encephalic region	r	P	r	P	r	P	r	P	r	P
Left prefrontal lobe	0.057	0.751	-0.095	0.601	0.014	0.937	-0.322	0.067	0.111	0.540
Right prefrontal lobe	-0.783	0.014^*	0.042	0.818	0.511	0.041^*	-0.217	0.225	0.110	0.541
Left aboral frontal lobe	0.228	0.203	-0.202	0.259	-0.154	0.392	-0.258	0.147	0.175	0.331
Right aboral frontal lobe	-0.094	0.603	0.121	0.502	0.149	0.407	0.009	0.962	-0.111	0.537
Left anterior temporal lobe	-0.031	0.865	-0.058	0.750	0.045	0.805	-0.231	0.196	-0.013	0.943
Right anterior temporal lobe	0.245	0.170	0.384	0.047^*	-0.170	0.344	-0.246	0.189	0.279	0.116
Left aboral temporal lobe	0.003	0.985	-0.016	0.932	0.100	0.581	-0.224	0.211	0.022	0.904
Right aboral temporal lobe	0.133	0.459	-0.217	0.224	-0.095	0.598	-0.277	0.193	0.263	0.139
Left cingulate gyrus	0.260	0.143	-0.338	0.054	-0.238	0.180	-0.406	0.119	0.283	0.110
Right cingulate gyrus	0.307	0.126	-0.296	0.073	-0.082	0.373	-0.455	0.106	0.178	0.243
Left parietal lobe	0.135	0.453	-0.141	0.435	-0.030	0.868	-0.327	0.063	0.123	0.494
Right parietal lobe	0.142	0.429	-0.139	0.441	-0.071	0.695	-0.250	0.161	0.058	0.749
Left occipital lobe	-0.111	0.538	0.084	0.641	0.082	0.648	0.076	0.673	-0.190	0.289
Right occipital lobe	-0.340	0.053	0.323	0.067	0.306	0.052	0.184	0.305	-0.143	0.251
Left basal ganglia	0.206	0.250	-0.226	0.206	-0.203	0.256	-0.199	0.267	0.229	0.200
Right basal ganglia	0.057	0.752	-0.07	0.697	-0.015	0.935	-0.156	0.387	0.025	0.889
Left thalamus	-0.262	0.140	0.249	0.163	0.610	0.049^*	0.078	0.668	-0.254	0.154
Right thalamus	-0.304	0.085	0.231	0.196	0.266	0.134	0.117	0.518	-0.299	0.091

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[1] Correspondence: Youhui Li; Department of Psychiatry; The First Affiliated Hospital of Zhengzhou University; Zhengzhou 450052 – China; E-mail: liyouhuiyoga@163.com