Neurological complications after H1N1 influenza vaccination

Complicações neurológicas após vacinação para gripe H1N1

Sir, the report on “neurological complications after H1N1 influenza vaccination¹” is very interesting. Lessa et al. reported that “H1N1 vaccination can result in important neurological complications probably secondary to post-vaccination inflammation¹” and “MRI detected abnormalities in all patients¹.” In fact, the neurological problem can be seen in H1N1 influenza and the MRI finding in the infected case is noted². The “diffuse prolonged T1 and T2 signal” is the main observation and this is the similar finding to the present described finding in post H1N1 influenza vaccination neurological complications¹. In the pharmacovigilance report, the myelin disorder, as detected by MRI finding¹, is the common adverse effect reaction due to H1N1 influenza vaccination³. Conclusively, MRI can be the good investigation for determining neurological complication resulted by both influenza infection and vaccination.

References

• ¹
  Lessa R, Castillo M, Azevedo R, Azevedo F, Azevedo H. Neurological complications after H1N1 influenza vaccination: magnetic resonance imaging findings. Arq Neuropsiquiatr. 2014;72(7):496-9. http://dx.doi.org/10.1590/0004-282X20140064
  » https://doi.org/10.1590/0004-282X20140064
• ²
  Zeng H, Quinet S, Huang W, Gan Y, Han C, He Y, Wang Y. Clinical and MRI features of neurological complications after influenza A (H1N1) infection in critically ill children. Pediatr Radiol. 2013;43(9):1182-9. http://dx.doi.org/10.1007/s00247-013-2682-5
  » https://doi.org/10.1007/s00247-013-2682-5
• ³
  Durrieu G, Caillet C, Lacroix I, Jacquet A, Faucher A, Quarest S et al. [National Campaign of Vaccination against the flu A (H1N1)v: National Follow-up of Pharmacovigilance]. Therapie. 2011;66(6):527-40. French. http://dx.doi.org/10.2515/therapie/2011075
  » https://doi.org/10.2515/therapie/2011075

Publication Dates

• Publication in this collection
  Dec 2014

History

• Received
  25 July 2014
• Reviewed
  08 Aug 2014
• Accepted
  28 Aug 2014