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Drug Interaction and Surgery, and the Biodistribuition of Radiopharmaceutical • Braz. arch. biol. technol. 51 (spe) • Dec 2008 • https://doi.org/10.1590/S1516-89132008000700033 linkcopy

Open-access Biodistribution of the radiopharmaceutical technetium-99m-sodium phytate in rats after splenectomy

AuthorshipSCIMAGO INSTITUTIONS RANKINGS

    Abstracts

    Drugs and surgery can interfere with the biodistribution of radiopharmaceuticals and data about the effect of splenectomy on the metabolism of phytate-Tc-99m are scarce. This study aimed at evaluating the interference of splenectomy on phytate-Tc-99m biodistribution and liver function in rats. The SP group rats (n=6) underwent splenectomy. In group C (control) the animals were not operated on. After 15 days, all rats were injected with 0.1mL of Tc-99m-phytate via orbital plexus (0.66MBq). After 30 minutes, liver samples were harvested, weighed and the percentage of radioactivity per gram (%ATI/g) was determined by a Wizard Perkin-Elme gama counter. The ATI%/g in splenectomized rats (0.99±0.02) was significantly higher than in controls (0.4±0.02), (p=0.034). ALT, AST and HDL were significantly lower in SP rats (p= 0.001) and leukocytosis was observed in SP rats. In conclusion, splenectomy in rats changed the hepatic biodistribution of Tc-99m-phytate and liver enzimatic activity.

    splenectomy; sodium phytate; biodistribution; liver

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