Clastogenic activity of integerrimine determined in mouse micronucleus assays

Gimmler-Luz, Maria Clara; Erdtmann, Bernardo

doi:10.1590/S0100-84551997000300008

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Animal genetics • Braz. J. Genet. 20 (3) • Sept 1997 • https://doi.org/10.1590/S0100-84551997000300008 linkcopy

Clastogenic activity of integerrimine determined in mouse micronucleus assays

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Abstracts

The pyrrolizidine alkaloid integerrimine, obtained from Senecio brasiliensis, was tested by acute dosing at two concentrations (18.75 and 37.5 mg/kg), and at different times, to establish its ability to induce micronuclei in mouse erythrocytes. This alkaloid was able to increase the frequency of micronucleated polychromatic erythrocytes in both, bone marrow and peripheral blood erythrocytes

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Sociedade Brasileira de Genética Rua Capitão Adelmio Norberto da Silva, 736, 14025-670 Ribeirão Preto SP - Brazil, Tel. / Fax: +55 16 621.8540, 620.1251, 620.1253 - Ribeirão Preto - SP - Brazil
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		No. of animals
Dose (mg/kg)	Sample time^a	T	S	A	Sex	No. of analyzed PCE	mPCE/1000 PCE (individual data)	Mean ± SD	PCE/NCE ± SD
N. Control		4	4	4	M	8,000	3.5, 3, 4.5, 3.5	3.6 ± 1.30	0.86 ± 0.42
		5	5	5	F	10,000	5, 5.5, 4.5, 0, 1	3.0 ± 2.71	1.10 ± 0.52
PA	24 h	5	5	4	M	8,000	5, 8, 8.5, 4.5	6.5 ± 2.38*	0.50 ± 0.16
(18.75)		5	5	5	F	10,000	1, 4, 4, 1, 2	2.4 ± 1.52	0.48 ± 0.23
	48 h	5	5	5	M	10,000	6, 5, 4, 2.5, 5	4.6 ± 1.67	0.65 ± 0.17
		5	5	5	F	10,000	4, 8, 5, 6, 4	5.4 ± 1.67*	0.52 ± 0.18
	72 h	5	4	4	M	8,000	8, 4, 4, 4	5.0 ± 2.00*	0.70 ± 0.18
		5	5	5	F	10,000	2.5, 6, 4, 5, 3.5	4.2 ± 1.48	0.60 ± 0.43
PA	24 h	5	5	4	M	8,000	5.5, 2.3, 5.5, 3	4.0 ± 1.67	0.79 ± 0.14
(37.50)		5	5	5	F	10,000	8.5, 4.5, 3.5, 3.5, 7.6	5.5 ± 2.37*	0.78 ± 0.16
	48 h	5	5	5	M	10,000	6, 6, 6.5, 8.5, 7	6.8 ± 1.30*	0.85 ± 0.44
		5	5	5	F	10,000	0.5, 3.5, 4.5, 3, 5	3.3 ± 1.75	0.76 ± 0.38
	72 h	5	4	4	M	8,000	2.5, 3, 2.5, 3.5	2.9 ± 0.48	0.54 ± 0.28
		5	5	5	F	10,000	5, 3, 2, 3, 6	3.8 ± 1.64	0.55 ± 0.20
P. Control	24 h	9	9	9	M	18,000	23, 19, 31, 18, 28.19, 34.5, 23, 22.3	24.2 ± 5.76*	0.61 ± 0.22
		7	7	7	F	14,000	33, 16, 18, 13.5, 20, 40, 27.3	24.0 ± 9.78*	0.59 ± 0.19
	48 h	5	5	5	M	10,000	15.5, 17, 13, 9.5, 11.5	13.3 ± 3.01*	0.31 ± 0.06*
		5	5	5	F	10,000	15, 12.5, 6.5, 11, 8	10.6 ± 3.42*	0.39 ± 0.30*

Dose (mg/kg)	Sample time^a	No. of animals			Sex	No. of analyzed PCE	mPCE/1000 PCE (individual data)	Means ± SD	PCE/NCE ± SD
Dose (mg/kg)	Sample time^a	T	S	A	Sex	No. of analyzed PCE	mPCE/1000 PCE (individual data)	Means ± SD	PCE/NCE ± SD
N. Control		9	9	8	M	24,000	3, 3, 1, 3.5, 2.5, 1, 1.5, 0	1.9 ± 1.24	55.20 ± 17.98
		10	10	10	F	25,000	1, 1, 2, 2, 1, 0, 1, 0.5, 1, 1	1.0 ± 0.60	76.20 ± 26.18
PA	24 h	5	5	4	M	8,000	8.6, 4.6, 7.5, 7.5	7.1 ± 1.71*	66.00 ± 42.70
(18.75)		5	5	4	F	6,000	1, 1, 2, 2	1.5 ± 0.58	46.00 ± 12.98*
	48 h	11	11	10	M	17,000	3, 2.5, 2.5, 2, 3, 1, 1, 1, 3, 1	2.0 ± 0.91	53.82 ± 22.71
		10	10	10	F	14,000	1.5, 2.5, 1, 3, 1, 0, 4.2, 1, 1	1.7 ± 1.18	60.38 ± 24.24
	72 h	5	4	4	M	5,000	2, 1, 4, 4	2.3 ± 1.99	61.50 ± 20.61
		5	5	5	F	5,000	2, 2, 1, 1, 1	1.4 ± 0.55	52.60 ± 12.78
	4 d	6	6	6	M	6,000	0, 3, 1, 0, 1, 5	1.7 ± 1.97	75.33 ± 18.99
		5	5	5	F	5,000	4, 1, 1, 3, 4	2.6 ± 1.52*	73.20 ± 22.95
	7 d	6	6	4	M	4,000	1, 0, 1, 0	0.5 ± 0.58	87.80 ± 61.11
		5	5	4	F	4,000	0, 1, 0, 0	0.3 ± 0.50	56.40 ± 12.99
	14 d	6	6	5	M	5,000	4, 4, 2, 1, 1	2.4 ± 1.52	55.20 ± 30.24
		5	5	4	F	4,000	2, 1, 1, 2	1.5 ± 0.58	43.40 ± 28.17
	21 d	6	6	5	M	5,000	0, 0, 1, 0, 0	0.2 ± 0.45	61.17 ± 15.00
		5	5	5	F	5,000	2, 0, 0, 0, 1, 0	0.6 ± 0.89	53.25 ± 2.99
PA	24 h	5	4	4	M	8,000	3.5, 7.5, 1.5, 6.5	4.7 ± 2.92*	41.80 ± 8.66
(37.50)		5	5	5	F	5,000	6, 6, 2, 2, 7	4.6 ± 2.41*	57.80 ± 32.97
	48 h	12	12	10	M	14,000	5.5, 4, 7, 7, 10, 6, 4, 10, 7, 11	7.2 ± 2.47*	46.60 ± 23.86
		11	11	11	F	15,000	2.5, 5, 6, 6.5, 6.5, 7, 12, 4, 5, 5, 1	5.5 ± 2.81*	50.50 ± 13.16
	72 h	5	4	4	M	7,000	4.5, 3.5, 4, 2	3.5 ± 1.27	38.00 ± 10.12
		5	5	5	F	7,000	3, 1, 4, 1.5, 5	2.9 ± 1.67*	45.70 ± 5.86*
	4 d	7	6	6	M	6,000	3, 2, 3, 2, 3, 3	2.7 ± 0.52	99.00 ± 25.18*
		6	6	6	F	5,000	2, 1, 6, 0, 0, 1	1.7 ± 2.25	93.80 ± 12.00
	7 d	7	6	5	M	5,000	1, 0, 2, 5, 6	2.8 ± 2.59	29.00 ± 1.73*
		6	6	4	F	4,000	1, 1, 1, 2	1.3 ± 0.50	37.00 ± 9.86*
	14 d	7	6	5	M	5,000	0, 1, 3, 1, 2	1.4 ± 1.14	63.40 ± 19.76
		6	6	5	F	5,000	1, 4, 3, 2, 1	2.2 ± 1.30	49.20 ± 19.03
	21 d	7	6	5	M	5,000	2, 0, 0, 0, 0	0.4 ± 0.89	63.50 ± 15.72
		6	6	6	F	6,000	0, 0, 0, 0, 1, 0	0.2 ± 0.41	47.80 ± 7.86*
P. Ccontrol	24 h	5	5	5	M	5,000	9, 10, 9, 5, 12	9.0 ± 2.55*
		5	5	5	F	9,000	10, 9, 9, 9.5, 10	9.5 ± 0.50*
	48 h	5	5	5	F	5,000	23, 35, 24, 26, 29	27.5 ± 4.83*	46.20 ± 12.40
		5	5	5	F	5,000	13, 19, 22, 12, 21	17.4 ± 4.62*	37.40 ± 13.26*