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Infective endocarditis on a percoutaneous prosthetic aortic valve with associated glomerulopathy due to Granulicatella adjacens

LETTER TO THE EDITOR

Infective endocarditis on a percoutaneous prosthetic aortic valve with associated glomerulopathy due to Granulicatella adjacens

Borja Quiroga* * Corresponding author at: Servicio de Nefrología. Hospital General Universitario Gregorio Marañón, C/ Dr. Esquerdo 46.28007 Madrid, Spain. E-mail address: borjaqg@gmail.com (B. Quiroga). ; David Arroyo; Eduardo Verde; Alia Eworo; Jose Luño

Nephrology Department; Microbiology and Infectious Diseases Department. Hospital General Universitario Gregorio Marañón, Madrid, Spain

Dear Editor,

Granulicatella adjacens is part of the normal flora of the mouth, bowels, and genitourinary system, and is known to be responsible for culture-negative infective endocarditis.1,2 Due to its difficulty to grow in usual culture media and its resistance to many antibiotics, the diagnosis and treatment of this pathogen are a challenge for the clinician.3

An 86 year-old man, with a history of aortic stenosis treated with percutaneous implantation of an aortic valve prosthesis, presented to the emergency room complaining of interscapular pain and palpable purpura of the lower limbs for the preceding 15 days. Vital signs revealed a temperature of 36.5ºC and a blood pressure of 140/90 mmHg. The blood panel showed an acute kidney injury (serum creatinine 5.42 mg/dL, urea 208 mg/dL). Other findings were serum calcium 7.9 mg/dL, C-reactive protein 6.6 mg/dL, and N-terminal proBNP 53950 ng/dL. He had an active urinalysis, with granular and red blood cell casts, a large amount of dysmorphic erythrocytes, and 1 gram of proteinuria per day. A renal ultrasound showed kidneys of normal size and echogenicity. A computed tomography (CT) was performed to rule out aortic pathology, revealing some degree of heart failure. Immunoassays were negative for p-ANCA, c-ANCA, and anti-glomerular basement membrane antibodies. Complement C3 levels were low (51.1 mg/dL) while complement C4 levels were normal (17 mg/dL). Blood cultures showed chains of Gram-positive cocci, later identified as Granulicatella adjacens, and transthoracic echocardiography revealed a lesion suspicious of vegetation on the prosthetic aortic valve. A primary oral focus was suspected, and an infection of the second lower right molar was confirmed. The tooth was surgically removed.

The patient was started empirically on intravenous daptomycin at a dose of 10 mg/Kg/48 h, and later was de-escalated to ceftriaxone due to antibiogram results. Control blood cultures were negative two days after initiation of therapy, which was maintained for six weeks; surgical approach was dismissed due to age, comorbidities, and the patient's desires. Renal function did not improve, but kidney biopsy could not be carried out because the patient was anemic and thrombocytopenic, and finally, the patient was started on chronic hemodialysis. Although discharged from hospital after an initial good evolution, the patient died three months later due to an Enteroccocus spp. sepsis related to the permanent catheter.

Acute kidney injury occurs in about 30% of the cases of infective endocarditis. There can be many causes, mainly prerenal and/or intrinsic involvement of the kidney. When there is parenchymatous injury, it can occur due to glomerular causes (membranoproliferative, crescentic, or acute postinfectious glomerulonephritis), tubulointerstitial nephritis (such as acute tubular necrosis or acute immuno-allergic interstitial nephritis) or vascular disease (renal infarctation, abscesses). In many cases, renal involvement goes unnoticed.4

To the best of our knowledge, many cases of G. adjacens infective endocarditis have been published, but this is the first one on a percutaneously implanted prosthesis.5,6

Conflict of interest

All authors declare to have no conflict of interest.

REFERENCES

1. Collins MD, Lawson PA. The genus Abiotrophia (Kawamura et al.) is not monophyletic: proposal of Granulicatella gen. nov., Granulicatella adiacens comb. nov., Granulicatella elegans comb. nov. and Granulicatella balaenopterae comb. nov. Int J Syst Evol Microbiol. 2000;50 Pt 1:365-9.

2. Brouqui P, Raoult D. Endocarditis due to rare and fastidious bacteria. Clin Microbiol Rev. 2001;4:177-207.

3. Durack DT. Prevention of infective endocarditis. N Engl J Med. 1995;332:38-44.

4. Majumdar A, Chowdhary S, Ferreira MA, et al. Renal pathological findings in infective endocarditis. Nephrol Dial Transplant. 2000;15:1782.

5. Hernando Real S, Carrero González P, Chaves González F, González González R. Endocarditis due to Granulicatella adiacens in an old patient. Med Clin (Barc). 2007;128:758.

6. Perkins A, Osorio S, Serrano M, et al. A case of endocarditis due to Granulicatella adiacens. Clin Microbiol Infect. 2003;9:576-7.

Received 19 June 2012

Accepted 10 July 2012

Available online 10 November 2012

  • 1. Collins MD, Lawson PA. The genus Abiotrophia (Kawamura et al.) is not monophyletic: proposal of Granulicatella gen. nov, Granulicatella adiacens comb. nov., Granulicatella elegans comb. nov. and Granulicatella balaenopterae comb. nov. Int J Syst Evol Microbiol. 2000;50 Pt 1:365-9.
  • 2. Brouqui P, Raoult D. Endocarditis due to rare and fastidious bacteria. Clin Microbiol Rev. 2001;4:177-207.
  • 3. Durack DT. Prevention of infective endocarditis. N Engl J Med. 1995;332:38-44.
  • 4. Majumdar A, Chowdhary S, Ferreira MA, et al. Renal pathological findings in infective endocarditis. Nephrol Dial Transplant. 2000;15:1782.
  • 5. Hernando Real S, Carrero González P, Chaves González F, González González R. Endocarditis due to Granulicatella adiacens in an old patient. Med Clin (Barc). 2007;128:758.
  • 6. Perkins A, Osorio S, Serrano M, et al. A case of endocarditis due to Granulicatella adiacens Clin Microbiol Infect. 2003;9:576-7.
  • *
    Corresponding author at: Servicio de Nefrología. Hospital General Universitario Gregorio Marañón, C/ Dr. Esquerdo 46.28007 Madrid, Spain. E-mail address:
    borjaqg@gmail.com (B. Quiroga).
  • Publication Dates

    • Publication in this collection
      11 Dec 2012
    • Date of issue
      Dec 2012
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