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Micology • Braz. J. Microbiol. 34 (1) • Apr 2003 • https://doi.org/10.1590/S1517-83822003000100001 linkcopy

Open-access Selection of 5-fluorocytosine-resistant mutants from an Aspergillus niger citric acid-producing strain

Seleção de mutantes resistentes à 5-fluorocitosina isolados de uma linhagem de Aspergillus niger produtora de ácido cítrico

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    Abstracts

    Mutants of Aspergillus niger N402, induced by UV mutagenesis, were selected and tested for resistance or sensitivity to 5-fluorocytosine. Some mutants showed increased citric acid production, which did not correlate with the intracellular amount of protein or ammonium ion. The resistance to 5-fluorocytosine proved to be a rational approach for isolation of new mutants with improved production of citric acid. The best mutant (FR13) accumulated double the amount of citric acid produced by the parental strain.

    Aspergillus niger; citric acid; 5-fluorocytosine

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    Sociedade Brasileira de Microbiologia USP - ICB III - Dep. de Microbiologia, Sociedade Brasileira de Microbiologia, Av. Prof. Lineu Prestes, 2415, Cidade Universitária, 05508-900 São Paulo, SP - Brasil, Ramal USP 7979, Tel. / Fax: (55 11) 3813-9647 ou 3037-7095 - São Paulo - SP - Brazil
    E-mail: bjm@sbmicrobiologia.org.br
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