| Subramaniam et al.(India, 2008)22. Subramaniam P, Babu KL, Nagarathna J. Oral manifestations in acute
lymphoblastic leukemic children under chemotherapy. J Clin Pediatr Dent.
2008;32:319-24.
|
To evaluate the oral manifestations in children with ALL
during chemotherapy |
58 (49 in the study group and 19 control children), age not
reported |
Performed through intraoral examinations |
1. Oral health; |
| 2. Compare outcomes between the study groups; |
| 3. Most common sites of oral manifestations; |
| 4. Gender; |
| 5. Chemotherapy phase |
| Torres et al. (Mexico, 2010)66. Torres EP, Ruíz MSR, Alejo GF, Hernández SJF, Pozos GAJ. Oral
manifestations in pediatric patients receiving chemotherapy for acute lymphoblastic
leukemia. J Clin Pediatr Dent. 2010;34:275-80.
|
To determine the prevalence of oralmanifestations in
pediatric patients with ALL receiving chemotherapy, and to evaluate risk
factors |
49 children aged 2 to 14 years |
Performed through intraoral examinations |
1. Oral health; |
| 2. Gender; |
| 3. Age; |
| 4. Time and type of treatment; |
| 5. Chemotherapy phase |
| Pels and Blaszczak(Poland, 2012)77. Pels E, Mielnik BM. Oral hygiene in children suffering from acute
lymphoblastic leukemia living in rural and urban regions. Ann Agric Environ Med.
2012;19:529-33.
|
To assess the state of oral hygiene in children with ALL
during anticancer treatment |
156 (78 in the study group and 78 in the control group),
aged 2 to 18 years |
Intraoral examination (simplified oral hygiene index
(OHI-S)/ plaque index and gingival index). Period of examinations: First
test: one month before chemotherapy; Second test: one to five months
after the start of treatment; Third test: six to 18 months of
treatment |
1. Oral hygiene; |
| 2. Gingival disease; |
| 3. Compare outcomes between the study groups; |
| 4. Treatment used |
| Sonis et al. (USA, 1995)88. Sonis AL, Waber DP, Sallan S, Tarbell NJ. The oral health of
long-term survivors of acute lymphoblastic leukaemia: a comparison of three treatment
modalities. Eur J Cancer B Oral Oncol. 2012;31:250-2.
|
To evaluate the prevalence of dental caries and periodontal
disease in children with ALL, comparing three treatment modalities |
64 children: first group (chemotherapy), Second group
(chemotherapy associated with 1,800 cranial cGy), Third group
(chemotherapy combined with 2,400 cranial cGy). Age < 5 years |
Performed through intraoral examinations. (DMF-T, OHI-M,
IG-M) |
1. Oral health; |
| 2. Dental caries; |
| 3. Bacterial plaque; |
| 4. Gingival disease; |
| 5. Compare outcomes between the study groups; |
| 6. Treatment used |
| Pinto et al.(Brazil, 2006)99. Pinto LP, Souza LB, Gordón-Núñez MA, Soares RC, Costa EMMB, Aquino
ARL, et al. Prevention of oral lesions in children with acute lymphoblastic leukemia.
Int J Pediatr Otorhinolaryngol. 2006;70:1847-51.
|
To evaluate the clinical aspects of oral mucosa in children
with ALL and determine the effect of chlorhexidine 0.12% in the
prevention of oral complications in these patients |
33 children. Group I (23 children): oral solution of
chlorhexidine 0.12%, twice a day; Group II (ten children): did not
receive this solution. Aged 2 to 15 years |
Clinical examination of the oral cavity/ digital palpation
of the oral mucosa, and cytological smears (obtained from the oral mucosa
at the beginning of chemotherapy intensification) |
1. Presence of mucositis; |
| 2. Effects of chlorhexidine 0.12%; |
| 3. Compare outcomes between the study groups |
| Soares et al. (Brazil, 2011)1010. Soares AF, Aquino ARL, Carvalho CHP, Nonaka CFW, Almeida D, Pinto
LP. Frequency of oral mucositis and microbiological analysis in children with acute
lymphoblastic leukemia treated with 0.12% chlorhexidine gluconate. Braz Dent J.
2011;22:312-6.
|
Evaluation of changes in the oral mucosa and qualitative
alterations of the microbiota in children with ALL undergoing
chemotherapy |
17 children, aged 2 to 12 years |
Clinical examination of the oral mucosa for the detection
of oral lesions |
1. Presence of mucositis; |
| 2. Effects of chlorhexidine 0.12% on oral microbiota |
| Williams MC. (England, 1992)1111. Williams MC, Martin MV. A longitudinal study of the effects on the
oral mucosa of treatment for acute childhood leukaemia. Int J Paediatr Dent.
1992;2:73-9.
|
To investigate the incidence of alterations in the oral
mucosa in a group of children during the first six months of anticancer
treatment |
24 children (12 children in the study group and 12 in the
control group). Age not reported |
1. Intraoral examination aimed at assessing the oral
manifestations; |
1. Oral health; |
| 2. Salivary flow; |
2. Amount of saliva; |
| 3. Amount of Candida; |
| 3. Presence of Candida in the oral mucosa; |
4. Number of neutrophils; |
| 4. Hematological examination |
5. Compare outcomes between the study groups |
| Mendonca et al. (2012, Brazil)1212. Mendonça RM, Araújo M, Levy CE, Morari J, Silva RA, Yunes JA, et al.
Prospective evaluation of HSV, Candida spp., and oral bacteria on the severity of
oral mucositis in pediatric acute lymphoblastic leukemia. Support Care Cancer.
2012;20:1101-7.
|
To evaluate the association of HSV-1,
Candida spp. and oral bacteria on the severity of
oral mucositis in childrenwith ALL |
71 patients, age not reported |
Oral examinations aimed at assessing the presence of oral
manifestations in children. |
1. Oral health; |
| 2. Evaluate the presence of Candida spp. and the
severity of mucositis in patients with ALL |
