Opiorphin is a pentapeptide, which could be isolated from human fluids and has a decreasing effect on pain.
Aim
Since lichen planus is a chronic mucocutaneous disease, which causes pain or burning feeling in the oral mucosa, this study aimed to compare salivary opiorphin levels of oral lichen planus (OLP) patients with healthy subjects.
Methods
This case-control study, was performed on 24 patients with OLP lesions and 21 healthy subjects. After collecting un-stimulated saliva, opiorphin levels were compared between two groups through statistical analyses.
Results
There was not any significant difference between OLP patients and healthy subjects according to salivary opiorphin concentration (p=0.378). Also, in the OLP group, opiorphin concentration was not significantly different between males and females (p=0.601). Analytical analysis could not show any remarkable difference between various severity of OLP lesions regarding to salivary opiorphin levels (p=0.653).
Conclusion
In this study, salivary opiorphin levels was not significantly different between patients with OLP and healthy subjects; however, more studies are suggested for better assessment of salivary opiorphin levels in various types of OLP lesions and its correlation with pain severity.
Oligopeptides; Lichen planus; oral
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