A new species of Manihot, named M. handroana was originally collected in the State of Minas Gerais, Brazil. This new species is related to M. jolyana N. D. Cruz, but differs from the latter in vegetative and floral characters. The upper part of its branches has less pilosity and the basal part is glabrate. The stipules are linear and smaller than M. jolyana, without glandulous teeth. The limb is deeply divided resulting in a more reduced disk, with cuspidate lobe apices and more glabrate upper surface. Some lower leaves show lobulation of the lobes and are slightly peltate. This plant also presents a scale-from expansion of petiole extremity in unlobulated leaves, as M. jolyana. The perianth of masculine and feminine flowers is larger, and of yellowish green color on its external part. The most evident character is the fleshy disk in feminine flowers, which increases in size during fruit development. The fruit shape is markedly triangulate, while in M. jolyana it is circular. The chromosome number for M. handroana is 2n = 36, as in M. jolyana.