Biomarkers blood and peritoneal fluid of bovines with intestinal diseases and traumatic reticulitis

Santos, Jomel Francisco dos; Rego, Rafael Otaviano do; Afonso, José Augusto Bastos; Soares, Pierre Castro; Mendonça, Carla Lopes de

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Ciência Animal Brasileira

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Medicina Veterinária • Ciênc. anim. bras. 21 • 2020 • https://doi.org/10.1590/1809-6891v21e-50941 copy

Biomarkers blood and peritoneal fluid of bovines with intestinal diseases and traumatic reticulitis

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

The objective of this study was to simultaneously evaluate biomarkers in the blood and peritoneal fluid (PF) of cattle with intestinal diseases (GI n=14) and traumatic reticulitis (GII n=13). A clinical examination and blood collection and PF were performed and subsequently, physical and cytological analysis of PF, as well as biochemical determinations in blood and PF. The analysis of variance was used at a 5% probability level comparing the groups and comparing blood and PF. In both groups, signs of apathy, dehydration and reticuloruminal hypomotility were evidenced, but the GI animals presented more expressive clinical alterations. In the cytological analysis of PF, a predominance of polymorfhonuclear was observed in both groups. Blood TP, globulin, cholesterol and GGT concentrations were higher in GII (P<0.05), and the A/G ratio was higher in GI (P <0.05). In PF, albumin and CK were higher in GI (P<0.05). In the comparison between blood and PF, the significant increase of L-lactate in the PF of both groups (P<0.05) was observed, characterizing the severity of the alterations present in the abdominal cavity. It is recommended the simultaneous evaluation of L-lactate in the blood and PF, as a tool for diagnosis and prognosis of bovine digestive diseases.

Keywords:
Digestive system; cattle; peritonitis; clinic biochemical; L-lactate

Citologia	Enfermidades intestinais (n=14)	Reticulites traumáticas (n=13)	Média geral	P
CTCN (/μL) Polimorfonucleares (%)	5512,00±7379,76^A 60,69+1 5,67^A	5013,00±8282,63^A 51,31 ±1 5,92^A	4959,00 54,83	0,7509 0,1752

Variáveis	Enfermidades intestinais - GI (n=14)
Variáveis	Sangue	LP	P
Proteína total (g/dL)	6,39±1,55^A	4,35±1,88^B	0,0049
Albumina (g/dL)	1,89+0,63^A	1,38±0,63^b	0,0454
Globulina (g/dL)	4,44+1,25^A	2,98±1,31^B	0,0074
Albumina/globulina	0,44±0,15^A	0,51±0,20^A	0,2906
Creatinina (mg/dL)	1,43+0,62^A	1,39±0,66^A	0,8500
Ureia (mg/dL)	67,07+46,80^A	68,53±58,76^A	0,9434
Glicose (mg/dL)	68,42±1 9,55^a	92,54±1 29,26^a	0,5124
Lactato L (mg/dL)	27,19±25,44^B	68,82±46,51^A	0,0092
Triglicérides (mg/dL)	18,63±6,17^A	24,23±23,07^A	0,3899
Colesterol (mg/dL)	64,04±55,82^A	46,27±36,34^A	0,3403
AST (U/L)	136,19+62,81^A	135,38+1 13,7^A	0,9817
GGT (U/L)	27,87+8,28^A	44,73+43,60^A	0,1675
LDH (U/L)	2261 ±837,73^A	1825±899,56^A	0,2040
CK (U/L)	635±624,28^A	426±558,50^A	0,3695
Ca²⁺ (mmol/L)	0,97+0,1 8^A	0,78+0,36^A	0,0947
Cl^- (mEq/L)	92,47+8,09^A	95,74+9,90^A	0,3559
Na⁺ (mmol/L)	128±7,76^A	122±8,21^A	0,0693
K⁺ (mmol/L)	3,61±0,85^B	5,83±3,30^A	0,0139

Variáveis	Reticulites traumáticas GII (n=13)
Variáveis	Sangue	LP	P
Proteína total (g/dL)	7,70±1,61^A	3,12±1,95^B	<.0001
Albumina (g/dL)	1,87±0,43^A	0,86±0,42^B	<.0001
Globulina (g/dL)	5,83±1,36^A	2,14±1,48^B	<.0001
Albumina/globulina	0,33±0,08^B	0,48±0,21^A	0,0257
Creatinina (mg/dL)	1,61 ±2,1 5^A	1,05±0,34^A	0,4238
Ureia (mg/dL)	49,38±31,99^A	46,65±25,50^A	0,8273
Glicose (mg/dL)	74,74±37,22^A	67,88±27,85^A	0,6320
Lactato L (mg/dL)	28,38±30,82^B	78,23±52,08^A	0,0092
Triglicérides (mg/dL)	14,43±5,01^A	22,44± 12,88^A	0,0520
Colesterol (mg/dL)	86,82±48,62^A	31,21±17,36^B	0,0025
AST (U/L)	204,39±1 49,60^A	96,54±54,34^B	0,0422
GGT (U/L)	115,35±1 15,51^A	44,70±36,94^B	0,0462
LDH (U/L)	2244,85±101 2,83^A	1323,39±1176,47^B	0,0139
CK (U/L)	835,02+1 225,39^A	182,14±1 84,32^A	0,1114
Ca²⁺ (mmol/L)	1,01 ±0,1 9^A	0,88±0,28^A	0,1885
Cl^- (mEq/L)	97,97±9,79^A	100,40±1 5,59^A	0,6509
Na⁺ (mmol/L)	125±11^A	121 ±1 0,83^A	0,3645
K⁺ (mmol/L)	3,92±0,44^B	8,79±4,05^A	0,0003

	Enfermidades digestivas
Variáveis	Enfermidades intestinais (n=14)	Reticulites traumáticas (n=13)	MG	P
Proteína total(g/dL)	6,40i1,55^B	7,7011,60^A	7,05	0,0419
Albumina (g/dL)	1,8910,63^A	1,8710,43^A	1,88	0,9143
Globulina (g/dL)	4,4411,25^B	5,8311,36^A	5,13	0,0120
Albumina/Globulina	0,4410,15^A	0,3310,08^B	0,38	0,0250
Ureia (mg/dL)	67,07146,80^A	49,38131,99^A	58,22	0,2661
Creatinina(mgZdL)	1,4410,62^A	1,6112,15^A	1,52	0,7756
Glicose (mg/dL)	68,42± 19,56^A	74,74137,22^A	71,58	0,5932
Lactato L (mg/dL)	27,19125,44^A	28,38130,82^A	27,78	0,9150
Colesterol(mg/dL)	64,04155,82^A	86,82148,62^A	75,43	0,0500
Triglicérides( mg/dL)	18,6316,17^A	14,4315,01^A	16,53	0,0646
LDH (U/L)	2261 ±837,73^A	2244,8511012,83^A	2252,92	0,9645
GGT (U/L)	27,8718,28^B	115,351115,51^A	71,61	0,0090
AST (U/L)	136,19162,81^A	204,391149,60^A	170,29	0,1300
CK(U/L)	6351624,28^A	835,0211225,39^A	735,02	0,5935
Ca²⁺ (mmol/L)	0,9710,18^A	1,0110,19^A	0,99	0,5632
Cl^- (mEq/L)	92,4718,09^A	97,9719,79^A	95,12	0,1236
Na⁺(mmol/L)	12817,76^A	125111,00^A	126,5	0,4686
K⁺ (mmol/L)	3,6110,85^A	3,9210,44^A	3,76	0,2627

	Enfermidades digestivas
Variáveis	Enfermidades intestinais (n=14)	Reticulites traumáticas (n=13)	MG	P
Proteína total (g/dL)	4,35±1,88^A	3,12±1,95^A	3,73	0,1395
Albumina (g/dL)	1,38±0,63^A	0,86+0,42^B	1,12	0,0371
Globulina (g/dL)	2,98±1,31^A	2,14+1,48 ^A	2,56	0,1653
Albumina/Globulina	0,51 ±0,20^A	0,48±0,21^A	0,49	0,7454
Uréia (mg/dL)	68,53±58,76^A	46,65±25,50^A	57,59	0,2853
Creatinina(mg/dL)	1,39±0,66^A	1,05±0,34^A	1,22	0,1520
Glicose(mg/dL)	92,53±1 29,2^A	67,88±27,85^A	80,20	0,4688
Lactato L (mg/dL)	68,82±46,51^A	78,23±52,08^A	73,52	0,6526
Colesterol (mg/dL)	46,27±36,34^A	31,21+17,36^A	38,74	0,2419
Triglicérides (mg/dL)	24,23±23,07^A	22,44+1 2,88^A	23,33	0,8289
LDH (U/L)	1825±899,56^A	1323,39±1 176,47^A	1574	0,2590
GGT (U/L)	44,73±43,60^A	44,70±36,94^A	44,71	0,9987
AST (U/L)	135,38±1 13,4^A	96,54±54,34^A	116	0,3323
CK(U/L)	426±558,50^A	182,14±184,32^A	304,10	0,0408
Ca²⁺ (mmol/L)	0,78±0,36^A	0,88±0,28^A	0,83	0,4920
Cl^- (mEq/L)	95,74±9,90^A	100,40±1 5,59^A	98,07	0,3908
Na⁺(mmol/L)	122±8,21^A	121 ±1 0,83^A	121,50	0,7826
K⁺ (mmol/L)	5,83±3,00^A	8,79+4,05^A	7,31	0,0633

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