Wabrek et al., 1980 (1111. Wabrek AJ, Burchell RC. Male sexual dysfunction associated with coronary heart
disease. Arch Sex Behav. 1980;9(1):69-75, http://dx.doi.org/10.1007/BF01541402. http://dx.doi.org/10.1007/BF01541402...
) |
Male |
IIEF (35) |
Six weeks after their first MI, 64% of patients presented with ED, 28% presented with decreased
sexual frequency, and 8% presented with premature ejaculation. |
Jaarsma et al., 1996 (1212. Jaarsma T, Dracup K, Walden J, Stevenson LW. Sexual function in patients with
advanced heart failure. Heart Lung. 1996;25(4):262-70.) |
Male and Female |
SAS and PAIS (3636. Derogates LR, Lopes MC. The Psychosocial Adjustment to Illness Scale (PAIS and
PAIS-SR): Administration, scoring and procedures manual-I. Baltimore: 1983. Clinical Psychometric
Research.) |
Heart failure resulted in significant changes in sexual desire and the frequency of sexual
activity. |
Greenstein et al., 1997 (1313. Greenstein A, Chen J, Miller H, Matzkin H, Villa Y, Braf Z. Does severity of
ischemic coronary disease correlate with erectile function? Int J Impot Res.
1997;9(3):123-6.) |
Male |
Questionnaire by O'Leary (37) |
The severity of CAD decreased the frequency of erections. |
Abramov LA et al., 1997 (1414. Abramov LA. Sexual life and sexual frigidity among women developing acute
myocardial infarction. Psychosom Med. 1997;38(6):418-25.) |
Female |
Student's t-test and X2 contingency (3838. Mills FC. Statistical Methods. New York, Henry Holt * Co. 1955, pp.
512-40.) |
High prevalence of reduced desire and sexual dissatisfaction among 50 patients (65%) after MI
compared with 20 (24%) controls. |
Drory et al., 1998 (1515. Drory Y, Kravetz S, Florian V, Weingarten M. Sexual activity after first acute
myocardial infarction in middle-aged men. Cardiology. 1998; 90(3):207-11,
http://dx.doi.org/10.1159/000006845. http://dx.doi.org/10.1159/000006845...
) |
Male |
QSF (3939. Sarramon JP, Malavaud B, Braud F, Bertrand N, Vaessen C, Rischmann P. Evaluation
of male sexual function by the International Index of Erectile Function after deep dorsal vein
arterializations of the penis. J Urol. 2000;166(2):576-80.) |
After MI, patients showed changes in sexual frequency (32%) associated with age and education.
For 23%, sexual dissatisfaction was correlated with age. |
Hultgren et al., 1999 (1616. Hultgren R, Gren BS, Derberg MSO, Takolander R, Wahlberg E, Wahlberg M, et al.
Sexual Function in Women Suffering from Aortoiliac Occlusive Disease. Eur J Vasc Endovasc
Surg. 1999;17(4):306-12, http://dx.doi.org/10.1053/ejvs.1998.0770. http://dx.doi.org/10.1053/ejvs.1998.0770...
) |
Female |
FSFI (4040. Rosen R, Brown C, Heiman J, Leiblum S, Meston C, Shabsigh R, et al. The Female
Sexual Function Index (FSFI): a multidimensional self-report instrument for the assessment of female
sexual function. J Sex Marital Ther. 2000;26(2):191-208,
http://dx.doi.org/10.1080/009262300278597. http://dx.doi.org/10.1080/00926230027859...
) |
Patients with AIOD experienced negative effects on sexual arousal, orgasm and vulvar
sensitivity. |
Drory et al., 2000 (1717. Drory Y, Kravetz S, Weingarten M. Comparison of sexual activity of women and men
after a first Acute myocardial infarction. Am J Cardiol. 2000;85(11):1283-7,
http://dx.doi.org/10.1016/S0002-9149(00)00756-6. http://dx.doi.org/10.1016/S0002-9149(00)...
) |
Male and Female |
QSF (3939. Sarramon JP, Malavaud B, Braud F, Bertrand N, Vaessen C, Rischmann P. Evaluation
of male sexual function by the International Index of Erectile Function after deep dorsal vein
arterializations of the penis. J Urol. 2000;166(2):576-80.) |
The frequency of and satisfaction with sexual activity were similarly reduced for both
sexes. |
Burchardt et al., 2001 (1818. Burchardt M, Burchardt T, Anastasiadis AG, Kiss AJ, Shabsigh A, De La Taille A,
et al. Erectile dysfunction is a marker for cardiovascular complications and psychological
functioning in men with hypertension. Int J Impot Res. 2001;13(5):276-81.) |
Male |
IIEF (3535. Rosen RC, Riley A, Wagner G, Osterloh IH, Kirkpatrick J, Mishap A. The
international index of erectile function (IIEF): a multidimensional scale for assessment of erectile
dysfunction. Urology. 1997;49(6):822-30,
http://dx.doi.org/10.1016/S0090-4295(97)00238-0. http://dx.doi.org/10.1016/S0090-4295(97)...
) and CESD (4141. Kohout FJ, Berkman LF, Evans DACornoni-Huntley. Two shorter forms of the CES-D
(Center for Epidemiological Studies Depression) depression symptoms index. J Aging Health.
1993;5(2):179-93.) |
ED was considered as a marker of cardiovascular complications (p<0.05) in
70 patients (70.6%) with hypertension. In total, 22 (30.6%) patients with ED showed signs of
depression. |
Montorsi et al., 2003 (1919. Montorsi F, Briganti A, Salonia A, Rigatti P, Margonato A, Macchi A, et al.
Erectile dysfunction prevalence, time of onset and association with risk factors in 300 consecutive
patients with acute chest pain and angiographically documented coronary artery disease. Eur Urol.
2003; 44(3):360-4, http://dx.doi.org/10.1016/S0302-2838(03)00305-1. http://dx.doi.org/10.1016/S0302-2838(03)...
) |
Male |
IIEF (3535. Rosen RC, Riley A, Wagner G, Osterloh IH, Kirkpatrick J, Mishap A. The
international index of erectile function (IIEF): a multidimensional scale for assessment of erectile
dysfunction. Urology. 1997;49(6):822-30,
http://dx.doi.org/10.1016/S0090-4295(97)00238-0. http://dx.doi.org/10.1016/S0090-4295(97)...
) |
ED occurred 38.8 months before the advent of CAD in 99 patients (67%) men. ED was evident before
heart disease in 70% of all cases. |
Vacanti et al., 2005 (2020. Vacanti L, Caramelli B. Distress: associated variables of erectile dysfunction
post-acute myocardial infarction. A pilot study. Int J Impot Res.
2005;17(2):204-6.) |
Male |
IIEF (3535. Rosen RC, Riley A, Wagner G, Osterloh IH, Kirkpatrick J, Mishap A. The
international index of erectile function (IIEF): a multidimensional scale for assessment of erectile
dysfunction. Urology. 1997;49(6):822-30,
http://dx.doi.org/10.1016/S0090-4295(97)00238-0. http://dx.doi.org/10.1016/S0090-4295(97)...
) and HADS (4242. Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr
Scand. 1983;67(6):361-70, http://dx.doi.org/10.1111/j.1600-0447.1983.tb09716.x. http://dx.doi.org/10.1111/j.1600-0447.19...
) |
After MI, patients showed an incidence of 40.5% of ED and depressive symptoms. |
Addis et al., 2005 (2121. - Addis IB, Christine C, Eric V, Feng L, Stuenkel CA, Hulley S. Sexual activity
and function in postmenopausal women with heart disease. Obstet Gynecol. 2005;106(1)121-7,
http://dx.doi.org/10.1097/01.AOG.0000165276.85777.fb. http://dx.doi.org/10.1097/01.AOG.0000165...
) |
Female
|
Logistic regression |
A total of 1,091 patients had SD, of whom 140 (13%) complained of one sexual problem, and 570
(52%) complained of two or more. |
Shi et al., 2006 (2222. Shi H, Zhang FR, Zhu CX, Wang S, Li S, Chen SW. Incidence of changes and
predictive factors for sexual function after coronary stenting. Andrologia.
2006;39(1):16-21.) |
Male |
IIEF (3535. Rosen RC, Riley A, Wagner G, Osterloh IH, Kirkpatrick J, Mishap A. The
international index of erectile function (IIEF): a multidimensional scale for assessment of erectile
dysfunction. Urology. 1997;49(6):822-30,
http://dx.doi.org/10.1016/S0090-4295(97)00238-0. http://dx.doi.org/10.1016/S0090-4295(97)...
) |
Patients with CAD in the acute (p>0.05) and chronic
(p<0.05) phases. |
Kazemi-Saleh et al., 2007 (2323. Kazemi-Saleh D, Pishgou B, Assari S, Tavallaii SA. Fear of sexual intercourse in
patients with coronary artery disease: A pilot study of associated morbidity. J Sex Med.
2007;4(6):1619-25.) |
Male |
HADS (4242. Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr
Scand. 1983;67(6):361-70, http://dx.doi.org/10.1111/j.1600-0447.1983.tb09716.x. http://dx.doi.org/10.1111/j.1600-0447.19...
) and RSS (4343. Kashern TM, Carmody TJ, Suppes T, Rush AJ, Crismon ML, Miller AL, et al.
Catching Up on Health Outcomes: The Texas Medication Algorithm Project. Health Serv Res. 2003;38(1
Pt 1):311-31.) |
Twenty-nine patients (33.3%) showed sexual fear, depressive symptoms and a decreased frequency
of sexual activity. |
Eyada et al., 2007 (2424. Eyada M, Atwa M. Sexual function in female patients with unstable angina or
non-ST-elevation myocardial infarction. J Sex Med. 2007;4 (5):1373-80.) |
Female |
ASEX (4444. McGahuey CA, Gelenberg AJ, Laukes CA, Moreno FA, Delgado PL, McKnight KM. The
Arizona Sexual Experience Scale (ASEX): reliability and validity. J Sex Marital Ther.
2000;26(1):25-40.) |
Pectoral angina had a negative effect on the frequency and sexual satisfaction of patients. |
Kaya et al., 2007 (2525. Kaya C, Yilmaz G, Nurkalem Z, Ilktac A, Karaman MI. Sexual function in women
with coronary artery disease: a preliminary study. Int J Impot Res.
2007;19(3):326-9.) |
Female |
FSFI (4040. Rosen R, Brown C, Heiman J, Leiblum S, Meston C, Shabsigh R, et al. The Female
Sexual Function Index (FSFI): a multidimensional self-report instrument for the assessment of female
sexual function. J Sex Marital Ther. 2000;26(2):191-208,
http://dx.doi.org/10.1080/009262300278597. http://dx.doi.org/10.1080/00926230027859...
) |
All FSFI domain scores, except satisfaction, were lower in patients with CAD compared with
healthy individuals (p<0.05). |
Lunelli et al., 2008 (2626. Lunelli RP, Rabello ER, Stein R, Goldmeier S, Moraes MA. Sexual activity after
myocardial infarction: taboo or lack of knowledge? Arq Bras Cardiol.
2008;90(3):156-9.) |
Male and Female |
Mann-Whitney tests (2626. Lunelli RP, Rabello ER, Stein R, Goldmeier S, Moraes MA. Sexual activity after
myocardial infarction: taboo or lack of knowledge? Arq Bras Cardiol.
2008;90(3):156-9.) |
In total, 60% of patients had doubts about their return to sexual activity, and 44% had reduced
their sexual frequency. |
Cook et al., 2008 (2727. Cook SC, Arnott LM, Nicholson LM, Cook LR, Sparks EA, Daniels CJ. Erectile
dysfunction in men with congenital heart disease. Am J Cardiol. 2008;102(12):1728-30,
http://dx.doi.org/10.1016/j.amjcard.2008.08.017. http://dx.doi.org/10.1016/j.amjcard.2008...
) |
Male |
t-tests with Bonferroni correction (4545. Games PA. An improved t table for simultaneous control on contrasts. J Am
Statistical Association. 1977;72(359):531-4.) |
Patients using BBs reported three times more ED (p = 0.045). |
Kazemi et al., 2008 (2828. Kazemi-Saleh D, Pishgoo B, Farrokhi F, Fotros A, Assari S. Sexual function and
psychological status among males and females with ischemic heart disease. J Sex Med.
2008;5(10):2330-7.) |
Male and Female |
RSS (4646. Tavallaii SA, Fathi-Ashtiani A, Nasiri M, Assari S, Maleki P, Einollahi B.
Correlation between sexual function and postrenal transplant quality of life; Does gender matter?
J Sex Medicine. 2007;4(6):1610-8.) and HADS (4242. Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr
Scand. 1983;67(6):361-70, http://dx.doi.org/10.1111/j.1600-0447.1983.tb09716.x. http://dx.doi.org/10.1111/j.1600-0447.19...
) |
Male and female patients with CAD and symptoms of depression had sex less frequently. Male
depression was correlated with the couple's fear of sexual intercourse. |
Schwarz et al., 2008 (2929. Schwarz ER, Kapur V, Bionat S, Rastogi S, Gupta R, Rosanio S. The prevalence and
clinical relevance of sexual dysfunction in women and men chronic heart failure.
Int J Impot Res. 2008;20(1):85-91.) |
Male and Female |
IIEF (3535. Rosen RC, Riley A, Wagner G, Osterloh IH, Kirkpatrick J, Mishap A. The
international index of erectile function (IIEF): a multidimensional scale for assessment of erectile
dysfunction. Urology. 1997;49(6):822-30,
http://dx.doi.org/10.1016/S0090-4295(97)00238-0. http://dx.doi.org/10.1016/S0090-4295(97)...
) and FSFI (4040. Rosen R, Brown C, Heiman J, Leiblum S, Meston C, Shabsigh R, et al. The Female
Sexual Function Index (FSFI): a multidimensional self-report instrument for the assessment of female
sexual function. J Sex Marital Ther. 2000;26(2):191-208,
http://dx.doi.org/10.1080/009262300278597. http://dx.doi.org/10.1080/00926230027859...
) |
Male and female patients showed a high prevalence of SD. |
Hoffman et al., 2010 (3030. Hoffman BM, Sherwood A, Smith PJ, Babyak MA, Doraiswamy PM, Hinderliter A, et
al. Cardiovascular disease risk, vascular health and erectile dysfunction among middle-aged,
clinically depressed men. Int J Impot Res. 2010;22(1):30-5.) |
Male |
ASEX (4444. McGahuey CA, Gelenberg AJ, Laukes CA, Moreno FA, Delgado PL, McKnight KM. The
Arizona Sexual Experience Scale (ASEX): reliability and validity. J Sex Marital Ther.
2000;26(1):25-40.) |
ED was associated with greater CVD risk and impaired vascular endothelial function in depressed
men. |
Lemogne et al., 2010 (3131. Lemogne C, Ledru F, Bonierbale M, Consoli SM. Erectile dysfunction and
depressive mood in men with coronary heart disease. Int J Cardiol.
2010;138(3):277-80.) |
Male |
IIEF-5 (4747. Rosen RC, Cappelleri JC, Smith MD, Lipsky J, Pena BM. Development and evaluation
of an abridged, 5-item version of the International Index of Erectile Function (IIEF-5) as a
diagnostic tool for erectile dysfunction. Int J Impot Res.
1999;11(6)319-24.), BDI-13 (4848. Beck AT, Beamesderfer A. Assessment of depression: the depression inventory. Mod
Probl Pharmacopsychiatry 1974;7(0):151-69.),STAI (4949. Busby DM, Christensen C, Crane RD, Larson JH. A revision of the Dyadic
Adjustment Scale for use with distressed and non-distressed couples: Construct hierarchy and
multidimensional scales. J Marital Fam Ther 1995;21:289-98,
http://dx.doi.org/10.1111/j.1752-0606.1995.tb00163.x. http://dx.doi.org/10.1111/j.1752-0606.19...
) and DS-14 (5050. Denollet J. DS14: standard assessment of negative affectivity, social Inhibition
and type-D personality. Psychosom Med. 2005;67(1):89-97,
http://dx.doi.org/10.1097/01.psy.0000149256.81953.49. http://dx.doi.org/10.1097/01.psy.0000149...
) |
The prevalence of ED (57.6%) was negatively associated with age and depressed mood. |
Kriston et al., 2010 (3232. Kriston L, Guenzler C, Agvemang A, Bengel J, Berner MM. Effect of sexual
function on Health-Related Quality of Life Mediated by Depressive Symptoms in Cardiac
Rehabilitation. Findings of the SPARK Project in 493 patients. J Sex Medicine.
2010;7(6):2044-55.) |
Male and Female |
IIEF (3535. Rosen RC, Riley A, Wagner G, Osterloh IH, Kirkpatrick J, Mishap A. The
international index of erectile function (IIEF): a multidimensional scale for assessment of erectile
dysfunction. Urology. 1997;49(6):822-30,
http://dx.doi.org/10.1016/S0090-4295(97)00238-0. http://dx.doi.org/10.1016/S0090-4295(97)...
), FSFI (4040. Rosen R, Brown C, Heiman J, Leiblum S, Meston C, Shabsigh R, et al. The Female
Sexual Function Index (FSFI): a multidimensional self-report instrument for the assessment of female
sexual function. J Sex Marital Ther. 2000;26(2):191-208,
http://dx.doi.org/10.1080/009262300278597. http://dx.doi.org/10.1080/00926230027859...
) and HADS (4242. Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr
Scand. 1983;67(6):361-70, http://dx.doi.org/10.1111/j.1600-0447.1983.tb09716.x. http://dx.doi.org/10.1111/j.1600-0447.19...
) |
ED was found in 20.3% of men, and SD was found in 43.1% of women. Symptoms of moderate
depression were found in 16.5% and 14.4% of men and women, respectively. |
Foruzan-Nia et al., 2011 (3333. Foruzan-Nia SK, Abdollahi MH, Hekmatimoghaddam SH, Namayandeh SM, Mortazavi MH.
Incidence of sexual dysfunction in men after cardiac surgery in Afshar hospital, Yazd.
J Reproductive Medicine. 2011;9(2):89-94.) |
Male |
IIEF (3535. Rosen RC, Riley A, Wagner G, Osterloh IH, Kirkpatrick J, Mishap A. The
international index of erectile function (IIEF): a multidimensional scale for assessment of erectile
dysfunction. Urology. 1997;49(6):822-30,
http://dx.doi.org/10.1016/S0090-4295(97)00238-0. http://dx.doi.org/10.1016/S0090-4295(97)...
) |
SD was prevalent one year after MI. |
Lindau et al., 2012 (3434. Lindau ST, Abramsohn E, Gosch K, Wroblewski K, Spatz ES, Chan PS, et al.
Patterns and loss of sexual activity in the year following hospitalization for acute myocardial
infarction (a united states national multisite observational study). Am J Cardiol.
2012;109(10):1439-44, http://dx.doi.org/10.1016/j.amjcard.2012.01.355. http://dx.doi.org/10.1016/j.amjcard.2012...
) |
Male and Female |
PHQ-9 (5151. Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression
severity measure. J Gen Intern Med. 2001;16(9):606-13,
http://dx.doi.org/10.1046/j.1525-1497.2001.016009606.x. http://dx.doi.org/10.1046/j.1525-1497.20...
) and F-12 PCS (5252. Ware J, Kosinski M, Keller SD. A 12-item short-form health survey: construction
of scales and preliminary tests of reliability and validity. Med Care. 1996;34(3):220-33,
http://dx.doi.org/10.1097/00005650-199603000-00003. http://dx.doi.org/10.1097/00005650-19960...
) |
A lack of sexual desire contributed to a decrease in sexual frequency among 59% of women and 48%
of men. |