Vogtmann E (2020), USA |
Case-control |
16s rRNA |
Case: PDAC
Control: Submucosal lesions in the esophagus or stomach, Cholelithiasis or choledocholithiasis without cholangitis.
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Saliva |
Phylum: Bacteroidetes, Firmicutes, Proteobacteria
Family: Bacteroidaceae, Staphylococcaceae, Enterobacteriaceae, Lachnospiraceae
Genus: Lachnospiraceae G7
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Phylum: Proteobacteria
Family: Pasteurellaceae
Genus: Haemophilus
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Half E (2019), Israel |
Case-control |
16s rRNA |
PDAC |
Stool |
PDAC (compared with healthy individuals from the Israeli cohort): Phylum: Firmicutes, Verrucomicrobia, Bacterioidetes, Family: Veillonellaceae, Akkermansiaceae, Odoribacteraceae, Genus: Megasphaera, Akkermansia, Odoribacter
PDAC (compared to individuals with PDAC in the Chinese cohort): Phylum: Firmicutes, Family: Veillonellaceae
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Healthy (compared to individuals with PDAC in the Israeli cohort): Phylum: Firmicutes, Tenericutes, Family: Clostridiacea, Lachnospiraceae, Erysipelotrichaeceae, Ruminococcaceae, Genus: Clostridium, Anaerostipes, Faecalibacterium, Subdoligranulum
Healthy (compared to individuals with PDAC in the Chinese cohort): Phylum: Firmicutes, Family: Erysipelotrichaeceae, Clostridiaceae, Genus: Anaerostipes
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Olson SH (2017), USA |
Case-control |
16s rRNA |
Case: PDAC |
Saliva |
PDAC (compared to healthy control or IPMN): Phylum: Firmicutes, Family: Streptococcaceae, Genus: Streptococcus |
Healthy control (compared with PDAC): Phylum: Proteobacteria, Family: Pasteurellaceae, Neisseriaceae, Genus: Haemophilus, Neisseria |
Mei Q-X (2018), China |
Case-control |
16s rRNA |
Control: IPMN PDAC |
Duodenum |
PDAC (compared to healthy control): Phylum: Proteo-bacteria, Firmicutes, Deinococcus-Thermus; Family: Moraxellaceae, Comamonadaceae, Yersiniaceae, Comamonadaceae, Sphingomonadaceae, Bacillaceae, Deinococcaceae, Oxalobacteraceae; Genus: Acinetobacter, Aquabacterium, Rahnella, Delftia, Sphingobium, Massilia, Oceanobacillus, Deinococcus
Most Abundant PDAC: Phylum: Firmicutes, Proteobacteria, Bacteroidetes; Family: Bacillaceae, Pseudomonadaceae, Streptococcaceae; Genus: Bacillus, Pseudomonas, Lactococcus
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Control (compared to PDAC): Phylum: Proteobacteria, bacterioidetes, firmicutes; Family: Enterobacteriaceae, Pseudomonadaceae, Incertae sedis, Phophyromonadaceae, Paenibacillaceae; Genus: Escherichia, Shigella, Pseudomonas, Enhydrobacter, Porphyromonas, Paenibacillus
More abundant healthy: Phylum: Firmicutes, Proteobacteria, Bacteroidetes; Family: Bacillaceae, Pseudomonadaceae, Streptococcaceae; Genus: Bacillus, Pseudomonas, Lactococcus
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Torres PJ (2015), USA |
Case-control |
16s rRNA |
PDAC |
Saliva |
Increase in PDAC (compared to other diseases and healthy controls): Phylum: Fusobacteria, Family: Leptotrichiaceae, Genus: Leptotrichia
Decrease in PDAC (compared to other diseases and healthy controls): Phylum: Bacteroidetes, Proteobacteria, Family: Porphyromonadaceae, Neisseriaceae; Genus: Porphyromonas, Neisseria
|
No descript |
Ren Z (2017), China |
Case-control |
16s rRNA |
PDAC |
Stool |
PDAC (compared with healthy control group): Phylum: Bacteroidetes; Family: Prevotellaceae, Veillonellaceae, Enterobacteriaceae; Genus: Prevotella, Hallella, Veillonella, Selenomonas, Klebsiella, Enterobacter, Cronobacter
Most Abundant PDAC: Phylum: Bacteroidetes, Firmicutes e Proteobacteria
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Healthy control group (compared with PDAC): Phylum: Firmicutes, Proteobacteria, Actinobacteria; Family: Ruminococcaceae, Lachnospiraceae, Clostridiaceae, Bifidobacteriaceae; Genus: Gemmiger, Flavonifractor, Coprococcus, Blautia, Anaerostipes, Clostridium IV, Butyricicoccus, Dorea, Bifidobacterium
More abundant healthy control group: Phylum: Bacteroidetes, Firmicutes e Proteobacteria
|
Fan X (2018), USA |
Case-control |
16s rRNA |
PDAC |
Saliva |
Associated with high risk of pancreatic cancer: Phylum: Bacterioidetes1, Proteobacteria2; Family: Porphyromonadaceae1, Pasteurellaceae2; Genus: Porphyromonas1, Aggregatibacter2; Especie: Porphyromonas gingivalis1, Aggregatibacter actinomycetemcomitans2 |
Associated with low risk of pancreatic cancer: Phylum: Fusobacteria; Family: Leptotrichiaceae; Genus: Leptotrichia |
Kohi S (2021), USA |
Case-control |
16s rRNA |
PDAC |
Duodenal fluid |
Most Abundant PDAC: Phylum: Proteobacteria |
Phylum: Firmicutes, Bacteroidetes, Proteobacteria: Class: Bacilli, Bacteroidia, Negativicutes, Gammaproteobacteria; Order: Lactobacillales, Bacteroidales, Selenomonadales; Familia: Streptococcaceae, Veillonellaceae, Prevotellaceae; Genus: Streptococcous, Veillonella, Prevotella 7 |
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|
|
Pancreatic cyst |
|
PDAC (compared with healthy control group): Phylum: Actinobacteria, Fusobacteria, Firmicutes; Family: Bifidobacteriaceae, Lactobacillaceae, Enterococcaceae; Genus: Bifidobacterium, Fusobacterium, Enterococcus
PDAC (compared with pancreatic cyst): Phylum: Proteobacteria, Bifidobacterium, Enterococcus; Genus: Escherichia-Shigella, Clostridium sensu strictu, Enterococcus, Bifidobacterium
STS: Class: Fusobacteria, Actinobacteria, Betaproteobacteria; Genus: Fusobacterium, Rothia, Neisseria
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Cyst: Family: Porphyromonadaceae, Corynebacteriaceae, Leptotrichiaceae; Genus: Streptococcus, Veillonella, Prevotella
There was no difference between cyst and control
|
Saab M (2021), France |
Case-control |
16s rRNA |
CCA |
Bile |
CCA (compared with biliary lithiasis): Phylum: Bacteroidetes; Family: Bacteroidaceae; Genuss: Streptococcus, Bacteroides e Pyramidobacter |
Biliary lithiasis (compared with CCA): Phylum: Firmicutes; Family: Clostridiaceae, Enterobacteriaceae, Fusobacteriaceae, Enterococcaceae; Genus: Clostriduim, Klebsiella, Fusobacterium e Enterococcus |
Sun H (2020), China |
Case-control |
16s rRNA |
Biliary lithiasis PDAC
BPD (benign pancreatic disease)
|
Saliva |
PDAC e BPD (compared with Healthy control group): Phylum: Spirochaetes; Family: no important variation
Most Abundant in PDAC cases: Phylum: Bacteroidetes; Family: Prevotellaceae, Genus: Neisseria, Veillonella
|
Healthy control group (compared with PDAC e BPD): Phylum: Proteobacteria; Family: Neisseriaceae
Most Abundant in Healthy control group: Phylum: Proteobacteria; Family: Neisseriaceae; Genus: Neisseria
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Wei AL (2020), China |
Case-control |
16s rRNA |
PDAC |
Saliva |
Increased in PDAC cases (compared with Healthy control group): Phylum: Firmicutes, Fusobacteria, Actinobacteria, Proteobacteria; Family: Streptococcaceae, Lactobacillaceae, Leptotrichiaceae, Actinomycetaceae, Micrococcaceae, Enterobacteriaceae; Genus: Streptococcus, Lactobacillus, Leptotrichina, Actinomyces, Rothia, Escherichia
Associated with high risk of pancreatic cancer: Phylum: Firmicutes, Fusobacteria; Family: Streptococcaceae, Leptotrichiaceae; Genus: Streptococcus, Leptotrichia
|
Reduced in PDAC cases (compared with Healthy control group): Phylum: Proteobacteria, Firmicutes, Bacteroidetes; Family: Neisseriaceae, Veillonellaceae, Porphyromonadaceae, Flavobacteriaceae, Prevotellaceae; Genus: Neisseria, Selenomonas, Porphyromnas, Tannerella, Capnocytophaga, Alloprevotella
Associated with low risk of pancreatic cancer: Phylum: Proteobacteria, Bacteroidetes; Family: Neisseriaceae, Prevotellaceae; Genus: Neisseria, Veillonella
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