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Neuropsychiatric Lupus Erythematosus: Future Directions and Challenges; a Systematic Review and Survey

Abstract

This study aimed to systematically review neuropsychiatric lupus erythematosus (NPSLE) and establish a simplified diagnostic criterion for NPSLE.

Publications from 1994 to 2018 in the database (Wanfang data (http://www.wanfangdata.com.cn/index.html) and China National Knowledge Internet (http://www.cnki.net)) were included. In total, 284 original case reports and 24 unpublished cases were collected, and clinical parameters were analyzed. An attempt was made to develop a set of simplified diagnostic criteria for NPSLE based on cases described in the survey and literature; moreover, and pathophysiology and management guidelines were studied.

The incidence rate of NPSLE was estimated to be 12.4% of SLE patients in China. A total of 408 NPSLE patients had 652 NP events, of which 91.2% affected the central nervous system and 8.8% affected the peripheral nervous system. Five signs (manifestations, disease activity, antibodies, thrombosis, and skin lesions) showed that negative and positive predictive values were more than 70%, included in the diagnostic criteria. The specificity, accuracy, and positive predictive value (PPV) of the revised diagnostic criteria were significantly higher than those of the American College of Rheumatology (ACR) criteria (χ2=13.642, 15.591, 65.010, p<0.001). The area under the curve (AUC) for revised diagnostic criteria was 0.962 (standard error=0.015, 95% confidence intervals [CI] =0.933-0.990), while the AUC for the ACR criteria was 0.900 (standard error=0.024, 95% CI=0.853-0.946). The AUC for the revised diagnostic criteria was different from that for the ACR criteria (Z=2.19, p<0.05).

Understanding the pathophysiologic mechanisms leading to NPSLE is essential for the evaluation and design of effective interventions. The set of diagnostic criteria proposed here represents a simplified, reliable, and cost-effective approach used to diagnose NPSLE. The revised diagnostic criteria may improve the accuracy rate for diagnosing NPSLE compared to the ACR criteria.

Neuropsychiatric Lupus Erythematosus; Diagnostic Criteria; Management


INTRODUCTION

Systemic lupus erythematosus (SLE) affects the nervous system, causing a variety of manifestations, including those of the central nervous system (CNS) and peripheral nervous system (PNS). The neuropsychiatric lupus erythematosus (NPSLE) is a severe complication of SLE. NPSLE is characterized by a variety of neurological manifestations; its diagnosis has been a formidable challenge for rheumatologists (11. Zardi EM, Giorgi C, Zardi DM. Diagnostic approach to neuropsychiatric lupus erythematosus: what should we do? Postgrad Med. 2018;130(6):536-47. https://doi.org/10.1080/00325481.2018.1492309.
https://doi.org/10.1080/00325481.2018.14...
). NPSLE can present with numerous symptoms that are frequently overlooked despite being associated with increased mortality and morbidity (22. Ward MM. Premature morbidity from cardiovascular and cerebrovascular diseases in women with systemic lupus erythematosus. Arthritis Rheum. 1999;42(2):338-46. https://doi.org/10.1002/1529-0131(199902)42:2<338::AID-ANR17>3.0.CO;2-U.
https://doi.org/10.1002/1529-0131(199902...
). Because of the clinical heterogeneity of NPSLE, and because we lack evidence-based treatment and etiological insight, clinical management is complex. Obviously, NPSLE does not occur due to a single pathophysiological mechanism, and mechanisms may vary according to the pathoanatomic localization of NPSLE—CNS, PNS, and vascular.

The American College of Rheumatology (ACR) has identified 19 neuropsychiatric syndromes in SLE (33. [No authors listed]. The American College of Rheumatology nomenclature and case definitions for neuropsychiatric lupus syndromes. Arthritis Rheum. 1999;42(4):599-608. https://doi.org/10.1002/1529-0131(199904)42:4<599::AID-ANR2>3.0.CO;2-F.
https://doi.org/10.1002/1529-0131(199904...
), which can be divided into CNS and PNS manifestations. Although this classification includes manifestations without clear physiological and pathological mechanisms, it helps rheumatologists identify neurological involvement. The incidence of NPSLE was also thought to have decreased as a result of the improved outpatient detection and treatment of SLE. There was no epidemiological data on NPSLE in China. Moreover, to the best of our knowledge, no revised diagnostic criteria have been reported. This review outlines our clinical studies on NPSLE for approximately 20 years, based on the evidence from literature reviews and surveys, recommendations for the diagnostic criteria and management of NPSLE were established. It is hoped that this effort will be useful to rheumatologists for the diagnosis and treatment of patients with NPSLE.

Definition of NPSLE

NPSLE (44. Netto TM, Zimmermann N, Rueda-Lopes F, Bizzo BC, Fonseca RP, Gasparetto EL. Neuropsychiatric lupus: classification criteria in neuroimaging studies. Can J Neurol Sci. 2013;40(3):284-91. https://doi.org/10.1017/S0317167100014219.
https://doi.org/10.1017/S031716710001421...
) is a group of neurologic syndromes of the CNS and PNS and/or of psychiatric syndromes observed in patients with SLE in which other causes are excluded by laboratory, clinical, neuropsychological, and neuroimaging tests (55. Hanly JG, Urowitz MB, Sanchez-Guerrero J, Bae SC, Gordon C, Wallace DJ, et al. Neuropsychiatric events at the time of diagnosis of systemic lupus erythematosus: an international inception cohort study. Arthritis Rheum. 2007;56(1):265-73. https://doi.org/10.1002/art.22305.
https://doi.org/10.1002/art.22305...
). NPSLE is a general term used to describe the wide range of SLE-related complications in the CNS and PNS. This syndrome is different from other aspects of SLE because it can occur without any serological changes. Focal disease in the form of focal seizures or stroke is caused by lupus-related coagulopathies (66. Stock AD, Gelb S, Pasternak O, Ben-Zvi A, Putterman C. The blood brain barrier and neuropsychiatric lupus: new perspectives in light of advances in understanding the neuroimmune interface. Autoimmun Rev. 2017;16(6):612-9. https://doi.org/10.1016/j.autrev.2017.04.008.
https://doi.org/10.1016/j.autrev.2017.04...
). However, diffuse disease varies considerably among patients; symptoms include memory impairment, anxiety, general cognitive decline, and depression (77. Sciascia S, Bertolaccini ML, Baldovino S, Roccatello D, Khamashta MA, Sanna G. Central nervous system involvement in systemic lupus erythematosus: Overview on classification criteria. Autoimmun Rev. 2013;12(3):426-9. https://doi.org/10.1016/j.autrev.2012.08.014.
https://doi.org/10.1016/j.autrev.2012.08...
). NPSLE can exhibit manifestations similar to those of hormonal disturbances, metabolic, posterior reversible encephalopathy syndrome, thrombotic thrombocytopenic purpura (TTP), side effects of medications (especially corticosteroids), and infectious.

Epidemiology of NPSLE

The reported prevalence of NPSLE ranges from 6% to 91%; this variation is partly due to differences in research methods, such as screening methods, follow-up duration, design types, lack of specificity of many NP manifestations, and heterogeneous procedures of assessments (88. Hanly JG, Urowitz MB, Su L, Bae SC, Gordon C, Wallace DJ, et al. Prospective analysis of neuropsychiatric events in an international disease inception cohort of patients with systemic lupus erythematosus. Ann Rheum Dis. 2010;69(3):529-35. https://doi.org/10.1136/ard.2008.106351.
https://doi.org/10.1136/ard.2008.106351...
,99. Brey RL, Holliday SL, Saklad AR, Navarrete MG, Hermosillo-Romo D, Stallworth CL, et al. Neuropsychiatric syndromes in lupus: prevalence using standardized definitions. Neurology. 2002;58(8):1214-20. https://doi.org/10.1212/WNL.58.8.1214.
https://doi.org/10.1212/WNL.58.8.1214...
). A specific study on the prevalence of NPSLE has not yet been performed in China. Thus, the author attempted to investigate NPSLE nationwide. Publications from 1994 to 2018 in the database (Wanfang data (http://www.wanfangdata.com.cn/index.html) and China National Knowledge Internet (http://www.cnki.net)) were included, using the terms “neuropsychiatric lupus erythematosus”, “neuropsychiatric lupus”, “systemic lupus erythematosus AND nervous system”, “systemic lupus erythematosus AND neuropsychiatric”, the exclusion criteria were incomplete clinical data and unclear diagnosis. In total, 284 original case reports and 24 unpublished cases were collected, and the clinical parameters were analyzed. The incidence rate of NPSLE was estimated to be 12.4% of SLE patients in China, accounting for 10.2% of hospitalized patients with SLE. The number of patients with NPSLE managed by rheumatism departments has gradually increased in the last seven years (2011-2018), but has decreased in emergency units and neurology departments. This may be partly due to increased awareness of NPSLE because research activities have often been presented at meetings. Patients with a history of or concurrent NPSLE, APL antibodies, skin lesions, as well as those with generalized disease activity are at a higher risk of developing NPSLE. The most common causes of death were multiple organ failure (MOF, 35.2%), infection (22.3%), and acute kidney injury (AKI, 17.5%) (Figure 1). Multiple logistic regression indicated that pneumonia (OR=3.831; p=0.015), AKI (OR=3.300; p=0.028), and cardiac complications (OR=3.256; p=0.030) were significantly associated with mortality. Our study demonstrated that the mean age of patients with NPSLE was 32.1±12.1 years (range 12-53 years), which was not significantly different from the age of patients with SLE. However, there was significant difference in mortality between age at onset of NPSLE >14 and <14 years.

Figure 1
Causes of death in Chinese patients with neuropsychiatric lupus erythematosus.

Pathophysiology of NPSLE

The pathogenic etiologies of NPSLE are likely to be multifactorial and several pathophysiological mechanisms have been implicated. NPSLE symptoms develop from injury to the vasculature, blood-brain barrier (BBB), and brain parenchyma. Studies have shown that cytokines and autoantibodies may mediate the damage, leading to focal or diffuse effects on the CNS. The PNS is not protected by a BBB, so it is susceptible to the effects of immune complexes, circulating autoantibodies, and other inflammatory molecules (1010. Aranow C, Diamond B, Backay M. Pathogensesis of the Nervous System. In: Wallace DJ, Hahn BH, editors. Dubois’ Lupus Erythematosus and Related Syndromes. Philadelphia: Saunders; 2013:363-7.).

The brain parenchyma may be the target of infiltrating cells, cytokines, and autoantibodies, leading to either focal or diffuse injury. Cytokines and chemokines enter into the CNS through a permeabilized BBB from the peripheral circulation, or be produced within the CNS by microglia and astrocytes. Cytokines have direct effects on neurons and endothelial cells, leading to apoptosis and dysfunction. In mice, proinflammatory cytokines are associated with anhedonia, depression, lethargy, and social isolation, similar associations exist in humans (1111. Dinan TG. Inflammatory markers in depression. Curr Opin Psychiatry. 2009;22(1):32-6. https://doi.org/10.1097/YCO.0b013e328315a561.
https://doi.org/10.1097/YCO.0b013e328315...
). The cerebrospinal fluid (CSF) examination of patients with NPSLE showed that there were many proinflammatory cytokines, including a proliferation-inducing ligand (APRIL), tumor necrosis factor (TNF), interleukin-6 (IL-6), IL-1, B cell-activating factor (BAFF), and interferon alpha (IFN-α). Although these molecules can trigger inflammatory responses, the pathophysiologic mechanism(s) still needs to be further studied.

Several antibodies are likely to be involved in the pathogenesis of NPSLE. Anti-neuronal antibodies were the first autoantibodies studied and recognized for the potential pathophysiological effects of NPSLE. APL antibodies are associated with cognitive impairment and cerebrovascular disease in patients with SLE. Various effects on coagulation proteins, platelets, and endothelial cells, including up regulation of tissue factor, are attributed to APL antibodies, which are not only serological markers, but also potentially direct lead to thrombosis and other NPSLE manifestations. Alpha-tubulin is considered as a target autoantigen of SLE, especially in patients with NPSLE with severe CNS manifestations. Studies have shown that antibodies to the N-methyl-D-aspartate receptor (NMDAR) may play a pathophysiological role in emotional and cognitive impairment of SLE. Anti-glyceraldehyde 3-phosphate dehydrogenase (GAPDH) antibodies are considered as new marker impairing cognitive processes and affecting emotional changes. These autoantibodies lead to selective impairment of cognition and spatial memory, possibly due to a substantial reduction in the spines of hippocampal pyramidal cells and dendritic processes, or as a result of microglia activation (1212. Ogawa E, Nagai T, Sakuma Y, Arinuma Y, Hirohata S. Association of antibodies to the NR1 subunit of N-methyl-D-aspartate receptors with neuropsychiatric systemic lupus erythematosus. Mod Rheumatol. 2016;26(3):377-83. https://doi.org/10.3109/14397595.2015.1083163.
https://doi.org/10.3109/14397595.2015.10...
).

The BBB protects the brain parenchyma, and its disruption causes potentially toxic cells and molecules access to the brain. Insults such as lipopolysaccharide (LPS) and systemic infections release soluble molecules, including IL-1, IL-6, and TNF, which activate brain endothelial cells, leading to up regulation of cell adhesion molecules, in turn causing BBB disruption (1313. Banks WA, Erickson MA. The blood-brain barrier and immune function and dysfunction. Neurobiol Dis. 2010;37(1):26-32. https://doi.org/10.1016/j.nbd.2009.07.031.
https://doi.org/10.1016/j.nbd.2009.07.03...
). Complement activation is another factor impairing BBB integrity (1414. Ward PA. The dark side of C5a in sepsis. Nat Rev Immunol. 2004;4(2):133-42. https://doi.org/10.1038/nri1269.
https://doi.org/10.1038/nri1269...
). The autoantibody must enter into brain tissue through a breach in the BBB, leading to clinical symptoms, and the location of the breach depends on the influencing factors. Vascular injury is very common in patients with SLE. Vascular abnormalities caused by vasculopathy, atherosclerotic disease, and hypercoagulability are other mechanisms leading to the pathogenesis of NPSLE. Microvascular damage leading to ischemia may result in ischemic patchy multiple sclerosis-like demyelination and cortical atrophy observed in lupus brains. Hemorrhage, tissue infarction, or more limited focal neuron damaged are caused by impaired blood flow.

Clinical Manifestations of NPSLE

In our study, 408 NPSLE patients had 652 NP events of which 91.2% affected the CNS and 8.8% affected the PNS. Of those with NP manifestations, 81.5% were diffuse and 18.5% were focal manifestations. Most patients, 61.2% had one neuropsychiatric event, while 38.7% of the patients had two or more manifestations. In 22.8%, nervous system involvement was the initial presentation of SLE, while 57.9% of NPSLE occurred at the onset of the disease or within the first five years after the onset of SLE.

Our study, using the ACR definitions, detected the presence of 13 of the 19 syndromes; cognitive dysfunction occurred in 42.1%, headache in 31.2%, acute confusional disorder in 16.8%, cerebrovascular disease in 12.3%, mood disorder in 10.8%, seizures in 8.9%, anxiety in 6.7%, psychoses in 6.5%, movement disorders in 2.3%, and PNS impairment in 8.8%. The most common clinical manifestations were cognitive dysfunction, followed by headache and acute confusional disorder. More than 40% of SLE patients had subjective complaints of cognitive impairment. Headaches are common in patients with NPSLE, tension headaches and migraine account for the majority. Ischemic strokes occurred in 78.4% of the observed cardiovascular disease (CVD), and 54.6% of stroke patients were found to have a recurrent stroke, leading to 58.7% morbidity and a 26.8% mortality rate. Our study has identified several risk factors for stroke in patients with NPSLE, including hypertension, advanced age, cigarette smoking, previous TIA or stroke, diabetes mellitus, dyslipidemia, cardiac valvular disease, APL antibodies, and a systemic lupus erythematosus disease activity Index (SLEDAI) score of >10. Peripheral nerve involvement occurs in 8.8% of patients with SLE, symptoms can be subtle or severe and overlooked by the rheumatologists. The most common manifestation is distal sensory or motor neuropathy (65.9%). A very important finding in our study that deserves emphasis was that the occurrence of neuropsychiatric events in these patients was associated with increased organ damage and reduced quality of life. This finding reinforces the need for further studies to assess the relationship between SLE-related morbidity and mortality and NPSLE manifestations.

Diagnostic challenges

NPSLE often presents as a diagnostic challenge, hampering early diagnostic of NPSLE is the lack of diagnostic criteria. After excluding secondary causes, NPSLE can be diagnosed if patients’ NP signs and symptoms are confirmed with abnormalities in the CSF analysis, EEG, neuropsychological examination, biopsy, and neuroimaging studies (1515. Bertsias GK, Ioannidis JP, Aringer M, Bollen E, Bombardieri S, Bruce IN, et al. EULAR recommendations for the management of systemic lupus erythematosus with neuropsychiatric manifestations: report of a task force of the EULAR standing committee for clinical affairs. Ann Rheum Dis. 2010;69(12):2074-82. https://doi.org/10.1136/ard.2010.130476.
https://doi.org/10.1136/ard.2010.130476...
). A careful and detailed physical examination and medical history, including a complete mental status and neurologic evaluation, and medication review, must be performed on each patient. Although NPSLE may be the sole or initial manifestation of SLE activity, our study shows that NPSLE frequently occurs when SLE is serologically and clinically active. In our study, higher SLEDAI score and APL antibody positivity increased the risk of development of NPSLE. Once NPSLE is suspected, certain antibodies may be useful for diagnosis, including APL, anti-ribosomal-P, anti-neuronal and anti-ganglioside antibodies (1616. Kivity S, Agmon-Levin N, Zandman-Goddard G, Chapman J, Shoenfeld Y. Neuropsychiatric lupus: a mosaic of clinical presentations. BMC Med. 2015;13:43. https://doi.org/10.1186/s12916-015-0269-8.
https://doi.org/10.1186/s12916-015-0269-...
,1717. Galeazzi M, Annunziata P, Sebastiani GD, Bellisai F, Campanella V, Ferrara GB, et al. Anti-ganglioside antibodies in a large cohort of European patients with systemic lupus erythematosus: clinical, serological, and HLA class II gene associations: European Concerted Action on the Immunogenetics of SLE. J Rheumatol. 2000;27(1):135-41.). By combining serological and clinical analysis with imaging findings, we can determine that the patient’s clinical manifestations are associated with active NPSLE rather than other causes. In our study, five signs (manifestations, disease activity, antibodies, thrombosis, and skin lesions) showed negative and positive predictive values were more than 70%, and consequently were included in the diagnostic criteria (Table 1).

Table 1
Sensitivity and specificity of the symptoms and signs of neuropsychiatric lupus erythematosus and analysis of their positive and negative predictive values.

To facilitate the diagnostic to the neurologic manifestations of suspected NPSLE origin and to assist the rheumatologist diagnosis it correctly, we suggest a revised set of diagnostic criteria. Our goal was to combine the current research progress with the need to simplify the diagnostic methods. As there is no diagnostic test for NPSLE, the diagnostic is confirmed by use of clinical assessment, disease activity, antibodies, thrombosis, and skin lesions. Therefore, an attempt was made to develop the diagnostic criteria for NPSLE based on cases described in the survey and literature. A confirmed diagnosis of SLE is essential for all the author’s criteria for NPSLE. The diagnostic criteria proposed here are based on an evidence-based approach; however, this is merely one attempt to simplify the diagnostic path of NPSLE (Table 2). There may be a need to expand the diagnostic criteria for NPSLE, which would be achieved only through further studies.

Table 2
Definition and diagnostic criteria for neuropsychiatric lupus erythematosus.

Since the publication of the ACR criteria, several researchers have used these criteria in their studies. The ACR criteria (1818. West SG. Clinical aspects of the nervous system. In: Wallace DJ, Hahn BH, editors. Dubois’ Lupus Erythematosus and Related Syndromes. Philadelphia: Saunders; 2013:368-81.) had a high sensitivity (91%) but a low specificity (46%). Our result showed that the specificity, accuracy, and positive predictive value (PPV) of the revised diagnostic criteria were significantly higher than those of the ACR criteria (χ2=13.642, 15.591, 65.010, p<0.001) (Table 3). The receiver operating characteristic curve (ROC) of the revised diagnostic criteria and ACR criteria analysis were individually plotted, and their area under the curve (AUC) were calculated (Figure 2). Result showed that the AUC for the revised diagnostic criteria was 0.962 (standard error=0.015, 95% confidence intervals [CI] =0.933-0.990). The AUC for the ACR criteria was 0.900 (standard error =0.024, 95% CI=0.853-0.946). The AUC for the revised diagnostic criteria was different from that for the ACR criteria (Z=2.19, p<0.05). The diagnostic criteria proposed here can comprise a simplified, reliable, and cost-effective approach for diagnosing NPSLE. Our study revealed that revised diagnostic criteria had significantly better accuracy, specificity and PPV than the ACR criteria. Therefore, the revised diagnostic criteria may improve accurate diagnosis of NPSLE compared to the ACR criteria, which is reflected in the improved higher AUC, specificity, and accuracy in our study.

Table 3
Comparison of the diagnostic performance of the two diagnostic criteria.

Figure 2
The receiver operating characteristic curve of (A) American College of Rheumatology diagnostic criteria (area under the curve=0.900) and (B) revised diagnostic criteria (area under the curve=0.962).

Severity and prognosis of NPSLE

The prognosis of patients with major NPSLE manifestations is less optimistic (1919. Alessi H, Dutra LA, Braga P Neto, Pedroso JL, Toso FF, Kayser C, et al. Neuropsychiatric Lupus in clinical practice. Arq Neuropsiquiatr. 2016;74(12):1021-30. https://doi.org/10.1590/0004-282x20160150.
https://doi.org/10.1590/0004-282x2016015...
). Coma, stroke, and status epilepticus are poor prognostic signs; aggressive evaluation and treatment are needed to prevent death or residual neurologic damage. Taking the factors including age, NP manifestations, hypertension, AKI, infection and treatments into consideration, univariate analysis showed that age <14 years at onset of NPSLE (p=0.001), AKI (p<0.001), infection (p=0.036), intrathecal methotrexate (MTX) plus dexamethasone (DXM) treatment (p<0.001) were the correlative factors of mortality. Multivariate logistic regression confirmed that infection (odds ratios [OR]=2.606, p=0.001), AKI (OR=4.711, p=0.003), and age <14 years at onset of NPSLE (OR=10.434, p=0.001) were risk factors for mortality, while intrathecal MTX plus DXM treatment (OR=0.12, p=0.006) was a protective factor. Moreover, we found that the proportion of patients under 14 years old in the deaths was significantly higher than that in the survivals (34.8% vs. 10.2%).

Our study indicated that the mortality for NPSLE was 11.2%, which is similar to 10.8% reported in patients with NPSLE (2020. Zhou HQ, Zhang FC, Tian XP, Leng XM, Lu JJ, Zhao Y, et al. Clinical features and outcome of neuropsychiatric lupus in Chinese: analysis of 240 hospitalized patients. Lupus. 2008;17(2):93-9. https://doi.org/10.1177/0961203307085671.
https://doi.org/10.1177/0961203307085671...
). In our study, the mortality of patients with NPSLE is high, so early diagnosis and appropriate treatment are needed to improve the prognosis of NPSLE. This study sought to determine the severity of illness in patients with NPSLE, or the perceived severity, based on two indexes: the British Isles lupus assessment group (BILAG) and SLEDAI. In our study, the means±SD for BILAG and SLEDAI scores were 26.62±6.02 and 15.75±3.20, respectively. Patients who died had significantly higher scores than those who survived: died versus survived=27.25±5.34 versus 16.88±3.87 (p=0.001) for BILAG and 21.25±2.19 versus 18.13±2.53 (p=0.019) for SLEDAI, respectively.

Management and treatment challenges

The management of patients with NPSLE includes providing symptomatic treatment, correcting the aggravating factors, and taking specific measures related to the disease process. Clinicians should try to identify and correct the possible aggravating factors, including metabolic or blood pressure abnormalities, and possible offending drugs. Therapy should not be delayed until the test results are available. Symptomatic treatment will be required according to the nature of NPSLE, and it may be initiated before disease-specific treatment. Patients’ manifestations such as headaches, anxiety or an infrequent seizure, or dysphoria, paresthesias may only need psychotropic medications, analgesics and antiseizure medications or neuroleptic agents, psychological support, respectively, and closely observe the progress of the nervous system (1818. West SG. Clinical aspects of the nervous system. In: Wallace DJ, Hahn BH, editors. Dubois’ Lupus Erythematosus and Related Syndromes. Philadelphia: Saunders; 2013:368-81.).

The treatment of NPSLE is mainly empirical, because few controlled clinical trials have been conducted. For patients with NPSLE who have progressive or severe, nonthrombotic or diffuse symptoms such as severe depression, acute confusional state, coma, psychosis, and aseptic meningitis, immunosuppressive therapy is beneficial in addition to symptomatic treatment. Most rheumatologists recommend taking 1 mg/kg prednisone daily in divided doses (2121. Sanna G, Bertolaccini ML, Khamashta MA. Neuropsychiatric involvement in systemic lupus erythematosus: current therapeutic approach. Curr Pharm Des. 2008;14(13):1261-9. https://doi.org/10.2174/138161208799316401.
https://doi.org/10.2174/1381612087993164...
). Conversion of prednisone to DXM (once a day, 12 to 20 mg) is another alternative, which is more effective than other corticosteroids in crossing the BBB. Continued failure to respond is an indication of plasmapheresis or cytotoxic medications or both, especially for comatose patients. In patients who did not respond to corticosteroid therapy, intravenous cyclophosphamide (CYC, 0.75 to 1.0 g/m2) given every 3 to 6 weeks has been reported to be beneficial (2222. Trevisani VF, Castro AA, Neves Neto JF, Atallah AN. Cyclophosphamide versus methylprednisolone for the treatment of neuropsychiatric involvement in systemic lupus erythematosus. Cochrane Database Syst Rev. 2000;(3):CD002265.,2323. Braile-Fabris L, Ariza-Andraca R, Olguin-Ortega L, Jara LJ, Fraga-Mouret A, Miranda-Limón JM, et al. Controlled clinical trial of IV cyclophosphamide versus IV methylprednisolone in severe neurological manifestations in systemic lupus erythematosus. Ann Rheum Dis. 2005;64(4):620-5. https://doi.org/10.1136/ard.2004.025528.
https://doi.org/10.1136/ard.2004.025528...
). Intrathecal MTX plus DXM (10 mg each time, once a week for 3 weeks) has been used successfully in our study, which has a rapid onset of action, less side effects, can improve drug bioavailability and avoid systemic toxicity, is an effective treatment for NPSLE (Table 4).

Table 4
Comparison of the intravenous cyclophosphamide and intrathecal methotrexate plus dexamethasone.

Patients with NPSLE with thrombotic or focal manifestations need to be evaluated immediately and aggressively. If vasculitis is suspected, high doses of corticosteroids similar to patients with nonthrombotic, diffuse, or severe manifestations are used. Cytotoxic medications should be used as early as possible. Clinical studies have shown that CYC is more effective than other immunosuppressive agents. Plasmapheresis may be beneficial within the first week to allow time for the CYC and corticosteroids to take effect (2121. Sanna G, Bertolaccini ML, Khamashta MA. Neuropsychiatric involvement in systemic lupus erythematosus: current therapeutic approach. Curr Pharm Des. 2008;14(13):1261-9. https://doi.org/10.2174/138161208799316401.
https://doi.org/10.2174/1381612087993164...
). Whether long-term antiplatelet therapy can prevent atheroma formation or thrombosis in the damaged vessel is unclear, but it is often used clinically (2424. Ahn GY, Kim D, Won S, Song ST, Jeong HJ, Sohn IW, et al. Prevalence, risk factors, and impact on mortality of neuropsychiatric lupus: a prospective, single-center study. Lupus. 2018;27(8):1338-47. https://doi.org/10.1177/0961203318772021.
https://doi.org/10.1177/0961203318772021...
).

Most strokes caused by thrombosis are associated with APL antibodies, while others are caused by emboli from damaged heart valves (2525. Ruiz-Irastorza G, Hunt BJ, Khamashta MA. A systematic review of secondary thromboprophylaxis in patients with antiphospholipid antibodies. Arthritis Rheum. 2007;57(8):1487-95. https://doi.org/10.1002/art.23109.
https://doi.org/10.1002/art.23109...
). These patients should be treated with antiplatelet drugs, statins, hydroxychloroquine, and/or anticoagulation therapy. Many experts recommend that warfarin be used lifelong in patients with cerebral artery thrombosis, maintaining the international standardized ratio (INR) of 3.0 to 3.5 (2121. Sanna G, Bertolaccini ML, Khamashta MA. Neuropsychiatric involvement in systemic lupus erythematosus: current therapeutic approach. Curr Pharm Des. 2008;14(13):1261-9. https://doi.org/10.2174/138161208799316401.
https://doi.org/10.2174/1381612087993164...
). In addition, any patient with a lupus anticoagulant and recurrent strokes should undergo testing for chromogenic factor X levels and periodic factor II; both these values should be maintained at 15% to 20% of normal to ensure adequate anticoagulation. Studies suggest that antimalarial agents (AMs) may prevent CNS flares, protect against worsening of brain lesions protect from seizures, but not from headaches (2323. Braile-Fabris L, Ariza-Andraca R, Olguin-Ortega L, Jara LJ, Fraga-Mouret A, Miranda-Limón JM, et al. Controlled clinical trial of IV cyclophosphamide versus IV methylprednisolone in severe neurological manifestations in systemic lupus erythematosus. Ann Rheum Dis. 2005;64(4):620-5. https://doi.org/10.1136/ard.2004.025528.
https://doi.org/10.1136/ard.2004.025528...
,2626. Piga M, Peltz MT, Montaldo C, Perra D, Sanna G, Cauli A, et al. Twenty-year brain magnetic resonance imaging follow-up study in Systemic Lupus Erythematosus: Factors associated with accrual of damage and central nervous system involvement. Autoimmun Rev. 2015;14(6):510-6. https://doi.org/10.1016/j.autrev.2015.01.010.
https://doi.org/10.1016/j.autrev.2015.01...
,2727. Hanly JG, Urowitz MB, O’Keeffe AG, Gordon C, Bae SC, Sanchez-Guerrero J, et al. Headache in systemic lupus erythematosus: results from a prospective, international inception cohort study. Arthritis Rheum. 2013;65(11):2887-97. https://doi.org/10.1002/art.38106.
https://doi.org/10.1002/art.38106...
). In addition, AMs diminish the risk for thrombosis by reducing blood viscosity, red blood cell sludging, and platelet aggregation; all of these can lead to cerebrovascular diseases in the context of APL antibodies (2828. Petri M. Use of hydroxychloroquine to prevent thrombosis in systemic lupus erythematosus and in antiphospholipid antibody-positive patients. Curr Rheumatol Rep. 2011;13(1):77-80. https://doi.org/10.1007/s11926-010-0141-y.
https://doi.org/10.1007/s11926-010-0141-...
).

Patients with moderate to high titers of APL antibodies, cerebral infarctions, and seizures should be started on anticoagulation therapy once seizures are controlled, despite the higher risk of falls and cerebral trauma. In steroid-unresponsive NPSLE, uncontrolled trials showed that B cell depletion therapy with anti-CD20 (rituximab) was effective (2929. Ramos-Casals M, Soto MJ, Cuadrado MJ, Khamashta MA. Rituximab in systemic lupus erythematosus: A systematic review of off-label use in 188 cases. Lupus. 2009;18(9):767-76. https://doi.org/10.1177/0961203309106174.
https://doi.org/10.1177/0961203309106174...
). High-dose CYC therapy or hematopoietic stem cell transplantation may be considered for patients with resistant and severe NPSLE (2121. Sanna G, Bertolaccini ML, Khamashta MA. Neuropsychiatric involvement in systemic lupus erythematosus: current therapeutic approach. Curr Pharm Des. 2008;14(13):1261-9. https://doi.org/10.2174/138161208799316401.
https://doi.org/10.2174/1381612087993164...
). Patients with chronic inflammatory demyelinating polyneuropathy (CIDP) or Guillain-Barré syndrome frequently undergo plasmapheresis or intravenous immunoglobulin as additional therapy. Patients with mononeuritis multiplex due to vasculitis should also be treated with cytotoxic medications such as CYC. In severe cases such as transverse myelitis, early combination of glucocorticoid and CYC can provide better outcomes than glucocorticoid alone (2323. Braile-Fabris L, Ariza-Andraca R, Olguin-Ortega L, Jara LJ, Fraga-Mouret A, Miranda-Limón JM, et al. Controlled clinical trial of IV cyclophosphamide versus IV methylprednisolone in severe neurological manifestations in systemic lupus erythematosus. Ann Rheum Dis. 2005;64(4):620-5. https://doi.org/10.1136/ard.2004.025528.
https://doi.org/10.1136/ard.2004.025528...
).

Future Directions

With the further study of the mechanism of immune abnormalities associated with active SLE, new therapies are being developed and new targets have been identified for the treatment of active disease. However, no new potential agents are on the horizon for NPSLE. Understanding the pathophysiologic mechanisms leading to NPSLE is essential for the evaluation and design of effective interventions (3030. Gelb S, Stock AD, Anzi S, Putterman C, Ben-Zvi A. Mechanisms of neuropsychiatric lupus: The relative roles of the blood-cerebrospinal fluid barrier versus blood-brain barrier. J Autoimmun. 2018;91:34-44. https://doi.org/10.1016/j.jaut.2018.03.001.
https://doi.org/10.1016/j.jaut.2018.03.0...
). Several difficult clinical situations need to be further elucidated. First, we currently lack comprehensive understanding of the mechanisms involved in NPSLE. Second, diagnostic tools and criteria for patients with NPSLE are limited because there are no in vivo imaging biomarkers providing direct evidence for BBB dysfunction (3131. Zardi EM, Taccone A, Marigliano B, Margiotta DP, Afeltra A. Neuropsychiatric systemic lupus erythematosus: tools for the diagnosis. Autoimmun Rev. 2014;13(8):831-9. https://doi.org/10.1016/j.autrev.2014.04.002.
https://doi.org/10.1016/j.autrev.2014.04...
). Third, randomized control trials (RCTs) to evaluate specific treatments for NPSLE are limited, and treatment strategies are based on small control trials and expert recommendations. There are few studies on NPSLE treatment; running such studies is difficult, because each trial may require a large number of patients and collaboration between centers from several countries. Finally, in clinical settings, the diagnosis and treatment of NPSLE requires the collaboration of neurologists and psychologists. In the next 10 years, the combination of NPSLE pathophysiological mechanisms, RCTs, and new techniques and methods may be helpful for the individualized treatment of patients with NPSLE. The clinical significance of symptom combination patterns and each symptom needs to be further studied.

REFERENCES

  • 1
    Zardi EM, Giorgi C, Zardi DM. Diagnostic approach to neuropsychiatric lupus erythematosus: what should we do? Postgrad Med. 2018;130(6):536-47. https://doi.org/10.1080/00325481.2018.1492309
    » https://doi.org/10.1080/00325481.2018.1492309
  • 2
    Ward MM. Premature morbidity from cardiovascular and cerebrovascular diseases in women with systemic lupus erythematosus. Arthritis Rheum. 1999;42(2):338-46. https://doi.org/10.1002/1529-0131(199902)42:2<338::AID-ANR17>3.0.CO;2-U
    » https://doi.org/10.1002/1529-0131(199902)42:2<338::AID-ANR17>3.0.CO;2-U
  • 3
    [No authors listed]. The American College of Rheumatology nomenclature and case definitions for neuropsychiatric lupus syndromes. Arthritis Rheum. 1999;42(4):599-608. https://doi.org/10.1002/1529-0131(199904)42:4<599::AID-ANR2>3.0.CO;2-F
    » https://doi.org/10.1002/1529-0131(199904)42:4<599::AID-ANR2>3.0.CO;2-F
  • 4
    Netto TM, Zimmermann N, Rueda-Lopes F, Bizzo BC, Fonseca RP, Gasparetto EL. Neuropsychiatric lupus: classification criteria in neuroimaging studies. Can J Neurol Sci. 2013;40(3):284-91. https://doi.org/10.1017/S0317167100014219
    » https://doi.org/10.1017/S0317167100014219
  • 5
    Hanly JG, Urowitz MB, Sanchez-Guerrero J, Bae SC, Gordon C, Wallace DJ, et al. Neuropsychiatric events at the time of diagnosis of systemic lupus erythematosus: an international inception cohort study. Arthritis Rheum. 2007;56(1):265-73. https://doi.org/10.1002/art.22305
    » https://doi.org/10.1002/art.22305
  • 6
    Stock AD, Gelb S, Pasternak O, Ben-Zvi A, Putterman C. The blood brain barrier and neuropsychiatric lupus: new perspectives in light of advances in understanding the neuroimmune interface. Autoimmun Rev. 2017;16(6):612-9. https://doi.org/10.1016/j.autrev.2017.04.008
    » https://doi.org/10.1016/j.autrev.2017.04.008
  • 7
    Sciascia S, Bertolaccini ML, Baldovino S, Roccatello D, Khamashta MA, Sanna G. Central nervous system involvement in systemic lupus erythematosus: Overview on classification criteria. Autoimmun Rev. 2013;12(3):426-9. https://doi.org/10.1016/j.autrev.2012.08.014
    » https://doi.org/10.1016/j.autrev.2012.08.014
  • 8
    Hanly JG, Urowitz MB, Su L, Bae SC, Gordon C, Wallace DJ, et al. Prospective analysis of neuropsychiatric events in an international disease inception cohort of patients with systemic lupus erythematosus. Ann Rheum Dis. 2010;69(3):529-35. https://doi.org/10.1136/ard.2008.106351
    » https://doi.org/10.1136/ard.2008.106351
  • 9
    Brey RL, Holliday SL, Saklad AR, Navarrete MG, Hermosillo-Romo D, Stallworth CL, et al. Neuropsychiatric syndromes in lupus: prevalence using standardized definitions. Neurology. 2002;58(8):1214-20. https://doi.org/10.1212/WNL.58.8.1214
    » https://doi.org/10.1212/WNL.58.8.1214
  • 10
    Aranow C, Diamond B, Backay M. Pathogensesis of the Nervous System. In: Wallace DJ, Hahn BH, editors. Dubois’ Lupus Erythematosus and Related Syndromes. Philadelphia: Saunders; 2013:363-7.
  • 11
    Dinan TG. Inflammatory markers in depression. Curr Opin Psychiatry. 2009;22(1):32-6. https://doi.org/10.1097/YCO.0b013e328315a561
    » https://doi.org/10.1097/YCO.0b013e328315a561
  • 12
    Ogawa E, Nagai T, Sakuma Y, Arinuma Y, Hirohata S. Association of antibodies to the NR1 subunit of N-methyl-D-aspartate receptors with neuropsychiatric systemic lupus erythematosus. Mod Rheumatol. 2016;26(3):377-83. https://doi.org/10.3109/14397595.2015.1083163
    » https://doi.org/10.3109/14397595.2015.1083163
  • 13
    Banks WA, Erickson MA. The blood-brain barrier and immune function and dysfunction. Neurobiol Dis. 2010;37(1):26-32. https://doi.org/10.1016/j.nbd.2009.07.031
    » https://doi.org/10.1016/j.nbd.2009.07.031
  • 14
    Ward PA. The dark side of C5a in sepsis. Nat Rev Immunol. 2004;4(2):133-42. https://doi.org/10.1038/nri1269
    » https://doi.org/10.1038/nri1269
  • 15
    Bertsias GK, Ioannidis JP, Aringer M, Bollen E, Bombardieri S, Bruce IN, et al. EULAR recommendations for the management of systemic lupus erythematosus with neuropsychiatric manifestations: report of a task force of the EULAR standing committee for clinical affairs. Ann Rheum Dis. 2010;69(12):2074-82. https://doi.org/10.1136/ard.2010.130476
    » https://doi.org/10.1136/ard.2010.130476
  • 16
    Kivity S, Agmon-Levin N, Zandman-Goddard G, Chapman J, Shoenfeld Y. Neuropsychiatric lupus: a mosaic of clinical presentations. BMC Med. 2015;13:43. https://doi.org/10.1186/s12916-015-0269-8
    » https://doi.org/10.1186/s12916-015-0269-8
  • 17
    Galeazzi M, Annunziata P, Sebastiani GD, Bellisai F, Campanella V, Ferrara GB, et al. Anti-ganglioside antibodies in a large cohort of European patients with systemic lupus erythematosus: clinical, serological, and HLA class II gene associations: European Concerted Action on the Immunogenetics of SLE. J Rheumatol. 2000;27(1):135-41.
  • 18
    West SG. Clinical aspects of the nervous system. In: Wallace DJ, Hahn BH, editors. Dubois’ Lupus Erythematosus and Related Syndromes. Philadelphia: Saunders; 2013:368-81.
  • 19
    Alessi H, Dutra LA, Braga P Neto, Pedroso JL, Toso FF, Kayser C, et al. Neuropsychiatric Lupus in clinical practice. Arq Neuropsiquiatr. 2016;74(12):1021-30. https://doi.org/10.1590/0004-282x20160150
    » https://doi.org/10.1590/0004-282x20160150
  • 20
    Zhou HQ, Zhang FC, Tian XP, Leng XM, Lu JJ, Zhao Y, et al. Clinical features and outcome of neuropsychiatric lupus in Chinese: analysis of 240 hospitalized patients. Lupus. 2008;17(2):93-9. https://doi.org/10.1177/0961203307085671
    » https://doi.org/10.1177/0961203307085671
  • 21
    Sanna G, Bertolaccini ML, Khamashta MA. Neuropsychiatric involvement in systemic lupus erythematosus: current therapeutic approach. Curr Pharm Des. 2008;14(13):1261-9. https://doi.org/10.2174/138161208799316401
    » https://doi.org/10.2174/138161208799316401
  • 22
    Trevisani VF, Castro AA, Neves Neto JF, Atallah AN. Cyclophosphamide versus methylprednisolone for the treatment of neuropsychiatric involvement in systemic lupus erythematosus. Cochrane Database Syst Rev. 2000;(3):CD002265.
  • 23
    Braile-Fabris L, Ariza-Andraca R, Olguin-Ortega L, Jara LJ, Fraga-Mouret A, Miranda-Limón JM, et al. Controlled clinical trial of IV cyclophosphamide versus IV methylprednisolone in severe neurological manifestations in systemic lupus erythematosus. Ann Rheum Dis. 2005;64(4):620-5. https://doi.org/10.1136/ard.2004.025528
    » https://doi.org/10.1136/ard.2004.025528
  • 24
    Ahn GY, Kim D, Won S, Song ST, Jeong HJ, Sohn IW, et al. Prevalence, risk factors, and impact on mortality of neuropsychiatric lupus: a prospective, single-center study. Lupus. 2018;27(8):1338-47. https://doi.org/10.1177/0961203318772021
    » https://doi.org/10.1177/0961203318772021
  • 25
    Ruiz-Irastorza G, Hunt BJ, Khamashta MA. A systematic review of secondary thromboprophylaxis in patients with antiphospholipid antibodies. Arthritis Rheum. 2007;57(8):1487-95. https://doi.org/10.1002/art.23109
    » https://doi.org/10.1002/art.23109
  • 26
    Piga M, Peltz MT, Montaldo C, Perra D, Sanna G, Cauli A, et al. Twenty-year brain magnetic resonance imaging follow-up study in Systemic Lupus Erythematosus: Factors associated with accrual of damage and central nervous system involvement. Autoimmun Rev. 2015;14(6):510-6. https://doi.org/10.1016/j.autrev.2015.01.010
    » https://doi.org/10.1016/j.autrev.2015.01.010
  • 27
    Hanly JG, Urowitz MB, O’Keeffe AG, Gordon C, Bae SC, Sanchez-Guerrero J, et al. Headache in systemic lupus erythematosus: results from a prospective, international inception cohort study. Arthritis Rheum. 2013;65(11):2887-97. https://doi.org/10.1002/art.38106
    » https://doi.org/10.1002/art.38106
  • 28
    Petri M. Use of hydroxychloroquine to prevent thrombosis in systemic lupus erythematosus and in antiphospholipid antibody-positive patients. Curr Rheumatol Rep. 2011;13(1):77-80. https://doi.org/10.1007/s11926-010-0141-y
    » https://doi.org/10.1007/s11926-010-0141-y
  • 29
    Ramos-Casals M, Soto MJ, Cuadrado MJ, Khamashta MA. Rituximab in systemic lupus erythematosus: A systematic review of off-label use in 188 cases. Lupus. 2009;18(9):767-76. https://doi.org/10.1177/0961203309106174
    » https://doi.org/10.1177/0961203309106174
  • 30
    Gelb S, Stock AD, Anzi S, Putterman C, Ben-Zvi A. Mechanisms of neuropsychiatric lupus: The relative roles of the blood-cerebrospinal fluid barrier versus blood-brain barrier. J Autoimmun. 2018;91:34-44. https://doi.org/10.1016/j.jaut.2018.03.001
    » https://doi.org/10.1016/j.jaut.2018.03.001
  • 31
    Zardi EM, Taccone A, Marigliano B, Margiotta DP, Afeltra A. Neuropsychiatric systemic lupus erythematosus: tools for the diagnosis. Autoimmun Rev. 2014;13(8):831-9. https://doi.org/10.1016/j.autrev.2014.04.002
    » https://doi.org/10.1016/j.autrev.2014.04.002

Publication Dates

  • Publication in this collection
    17 Apr 2020
  • Date of issue
    2020

History

  • Received
    9 Sept 2019
  • Accepted
    9 Dec 2019
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