Olfactory bulb transplantation in complete spinal cord injury: axonal
               regeneration and locomotor recovery

Arellanes-Chávez, Carlos Abraham; Bojórquez, Ariana Martínez; Martínez, Ernesto Ramos

doi:10.1590/S1808-1851201514010R128

Acessibilidade / Reportar erro

Brasil

Español English

sumário « anterior atual seguinte »

Sumário

Original Articles • Coluna/Columna 14 (1) • Jan-Mar 2015 • https://doi.org/10.1590/S1808-1851201514010R128 copy

Olfactory bulb transplantation in complete spinal cord injury: axonal regeneration and locomotor recovery

Transplante de bulbo olfatório em lesão medular completa: regeneração axonal e recuperação locomotora

Trasplante de bulbo olfatorio en lesiones medulares completas: regeneración axonal y recuperación locomotora

Authorship SCIMAGO INSTITUTIONS RANKINGS

OBJECTIVES:

To determine whether the intervention in rats is effective in terms of spinal cord regeneration and locomotor recovery, in order to obtain sufficient evidence to apply the therapy in humans.

METHODS:

a randomized, controlled, experimental, prospective, randomized trial was conducted, with a sample of 15 adult female Sprague-Dawley rats weighing 250 gr. They were divided into three equal groups, and trained for 2 weeks based on Pavlov's classical conditioning method, to strengthen the muscles of the 4 legs, stimulate the rats mentally, and keep them healthy for the surgery.

RESULTS:

It was observed that implantation of these cells into the site of injury may be beneficial to the process of spinal cord regeneration after spinal trauma, to mediate secretion of neurotrophic and neuroprotective chemokines, and that the OECs have the ability to bridge the repair site and decrease the formation of gliosis, creating a favorable environment for axonal regeneration.

CONCLUSION:

It is emphasized that the olfactory ensheathing glial cells possess unique regenerative properties; however, it was not until recently that the activity of promoting central nervous system regeneration was recognized.

Spinal cord injuries; Spinal cord regeneration; Olfactory bulb

Rat (Case)	12-14 days	40	60	80	120
1	Claw flexion of the toes (bilateral).	Flexion of the thigh and ankle, standing on 4 feet (original position). No strength.	Movement of the thigh, ankle and hip, walks on 4 feet. Grips the mesh with 4 feet. Recovery of strength.	Died at 80 days. Extraction of the spinal cord before death.
2	Claw flexion of the toes (bilateral).	Flexion of the thigh and ankle, standing on 4 feet (original position). No strength.	Movement of the thigh, ankle and hip. Grips the mesh with 4 feet. Recovery of strength.	Walks on 4 feet, speed and coordination of the movements of the hind feet recovered.	Drags the body with the hind feet (coordinated and rapid flexion and extension of the thigh, knee and the hip).
3	Bilateral claw flexion of the right muscle.	Bilateral flexion of the thigh and ankle, standing on 4 feet (original position). No strength.	Bilateral movement of the thigh, ankle and hip, walks on 4 feet. Grips the mesh with 4 feet. Recovery of strength.	Walks on 4 feet. Recovery of speed and coordination of the movements of the hind feet.	Drags the body with the hind feet (coordinated and rapid flexion and extension of the thigh, knee and hip).
4	Bilateral claw flexion of the toes.	Flexion of the left thigh and ankle, standing on 3 feet, the right foot remains extended behind.	Movement of the left thigh, ankle and hip (Flexion and extension), walks on 3 feet. Grips the mesh with 3 feet.	Bilateral movement of the thigh, ankle and hip (Flexion and extension), walking on 4 fours. Grips the mesh with 4 feet. Recovery of strength.	Walks on 3 feet with greater speed and coordinated movements. Increased strength of the right hind foot.
5	Bilateral claw flexion of the toes.	Bilateral flexion of the thigh and ankle. Standing on 4 feet (original position). No strength.	Bilateral movement of the thigh, ankle and hip (Flexion and extension), walks on 4 feet. Grips the mesh with 4 feet.	Bilateral movement of the thigh, ankle and hip (Flexion and extension), walking on 4 feet. Recovery of strength.

Sociedade Brasileira de Coluna Al. Lorena, 1304 cj. 1406/1407, 01424-001 São Paulo, SP, Brasil, Tel.: (55 11) 3088-6616 - São Paulo - SP - Brazil
E-mail: coluna.columna@uol.com.br

Acompanhe os números deste periódico no seu leitor de RSS

[1] Correspondence: Haciendas del Valle #7120-418, Plaza las Haciendas Chihuahua, Chihuahua. Mexico, C.P. 31238. drcarlosarellanes@gmail.com