Tarsal villonodular tenosynovitis (giant cell tumor of tendon sheath) in a dog

Daoualibi, Yasmin; Pohl, Camila Blanco; Kemper, Regina Tose; Rolemberg, Kahena Morais; Demeulemeester, Stéphanie Christine; Bandinelli, Marcele Bettim; Pavarini, Saulo Petinatti

doi:10.1590/0103-8478cr20200786

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PATHOLOGY • Cienc. Rural 51 (11) • 2021 • https://doi.org/10.1590/0103-8478cr20200786 copy

Tarsal villonodular tenosynovitis (giant cell tumor of tendon sheath) in a dog

Tenossinovite vilonodular pigmentada (tumor de células gigantes da bainha tendínea) tarsal em um cão

Authorship SCIMAGO INSTITUTIONS RANKINGS

ABSTRACT:

A 12-year-old female mixed-breed dog presented with lameness, pain, and an enlarged, non-ulcerated, nodular mass in the region proximal to the tarsal joint of the right pelvic limb. Surgical excision was performed, revealing a 6.5 cm mass adherent to the deep flexor tendon and adjacent tissues. The cut section had cysts filled with blackened clotted material, which exuded reddish serous fluid. Microscopically, the cysts were filled with red blood cells and were either denuded or covered by synoviocytes. In addition, the mass was characterized by marked fibrovascular connective tissue associated with siderophages and multinucleated giant cells. These findings were consistent with those of pigmented villonodular tenosynovitis, a rare condition affecting several animal species and humans.

Key words:
giant cell tumor of tendon sheath; joint; lameness; tendon; dog

Authorship

Yasmin Daoualibi ^*E-mail: yasmin.daoualibi@hotmail.com. *Corresponding author

Setor de Patologia Veterinária, Faculdade de Veterinária, Universidade Federal do Rio Grande do Sul (UFRGS), 91540-000, Porto Alegre, RS, Brasil. Universidade Federal do Rio Grande do Sul (UFRGS)BrazilPorto Alegre, RS, BrazilSetor de Patologia Veterinária, Faculdade de Veterinária, Universidade Federal do Rio Grande do Sul (UFRGS), 91540-000, Porto Alegre, RS, Brasil.

http://orcid.org/0000-0002-9365-2002

Camila Blanco Pohl

http://orcid.org/0000-0002-6971-8649

Regina Tose Kemper

http://orcid.org/0000-0001-9958-6213

Kahena Morais Rolemberg

Hospital Veterinário de Pequenos Animais, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brasil.Universidade Federal do Rio Grande do Sul (UFRGS)BrazilPorto Alegre, RS, BrazilHospital Veterinário de Pequenos Animais, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brasil.

http://orcid.org/0000-0002-1625-6719

Stéphanie Christine Demeulemeester

http://orcid.org/0000-0002-5248-0603

Marcele Bettim Bandinelli

http://orcid.org/0000-0001-8585-6956

Saulo Petinatti Pavarini

http://orcid.org/0000-0001-8980-6294

E-mail: yasmin.daoualibi@hotmail.com. ^*Corresponding author

DECLARATION OF CONFLICT OF INTEREST

The authors declare no conflicts of interest. The founding sponsors had no role in the design of the study, in the collection, analyses, or interpretation of data, in the writing of the manuscript or in the decision to publish the results.

AUTHORS’ CONTRIBUTIONS

The authors contributed equally to the manuscript.

SCIMAGO INSTITUTIONS RANKINGS

Figures

Figures (2)

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Figure 1 -
Tarsal pigmented villonodular tenosynovitis in a dog Radiographic examination of the lateral aspect of the right pelvic limb shows a nodule with increased radiopacity originating from the tarsal joint and extending to the adjacent tissues of the tibial and fibular bones. The center of the nodule shows small radiopaque and irregular areas that represent the bone tissue interspersed with the soft tissue of the mass. Inset: Macroscopicimage of the nodule in the cross-section shows a cystic aspect composed of thin whitish trabeculae. Additionally, discrete areas at the periphery of the mass of compact white tissue are seen with blackened multifocal clots.

Thumbnail

Figure 2 -
Histopathological and immunohistochemical aspects of tarsal pigmented villonodular tenosynovitis in a dog. A: Cysticareas filled with amorphous and eosinophilic material or red blood cells, in addition to multifocal areas of mineralization (H&E, 40x); B: Multiple cystic areas composed of thin, bare walls, containing collagenous connective tissue (H&E, 40x); C: Cystic areas are sometimes covered by layers of synoviocytes, with mononuclear inflammatory cells adjacent to them (H&E, 200x); D: Increased deposition of collagenous tissue with extensive hemorrhage and infiltration of siderophages (H&E,100×); E: Well-differentiated bone trabeculae associated with osteoblasts, osteocytes, and multinucleated giant cells (H&E, 400x); F: Discrete immunostaining for Iba-1 in the cytoplasm of monocytic cells and multinuclear giant cells that are adjacent to bone trabeculae (chromogen 3-amino-9-ethylcarbazole, 400x). (H&E, hematoxylin and eosin stain; IHC, Iba-1, ionized calcium binding adaptor molecule 1).

Figure 1 - Tarsal pigmented villonodular tenosynovitis in a dog Radiographic examination of the lateral aspect of the right pelvic limb shows a nodule with increased radiopacity originating from the tarsal joint and extending to the adjacent tissues of the tibial and fibular bones. The center of the nodule shows small radiopaque and irregular areas that represent the bone tissue interspersed with the soft tissue of the mass. Inset: Macroscopicimage of the nodule in the cross-section shows a cystic aspect composed of thin whitish trabeculae. Additionally, discrete areas at the periphery of the mass of compact white tissue are seen with blackened multifocal clots.

Figure 2 - Histopathological and immunohistochemical aspects of tarsal pigmented villonodular tenosynovitis in a dog. A: Cysticareas filled with amorphous and eosinophilic material or red blood cells, in addition to multifocal areas of mineralization (H&E, 40x); B: Multiple cystic areas composed of thin, bare walls, containing collagenous connective tissue (H&E, 40x); C: Cystic areas are sometimes covered by layers of synoviocytes, with mononuclear inflammatory cells adjacent to them (H&E, 200x); D: Increased deposition of collagenous tissue with extensive hemorrhage and infiltration of siderophages (H&E,100×); E: Well-differentiated bone trabeculae associated with osteoblasts, osteocytes, and multinucleated giant cells (H&E, 400x); F: Discrete immunostaining for Iba-1 in the cytoplasm of monocytic cells and multinuclear giant cells that are adjacent to bone trabeculae (chromogen 3-amino-9-ethylcarbazole, 400x). (H&E, hematoxylin and eosin stain; IHC, Iba-1, ionized calcium binding adaptor molecule 1).

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Tarsal villonodular tenosynovitis (giant cell tumor of tendon sheath) in a dog

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[1] E-mail: yasmin.daoualibi@hotmail.com. ^*Corresponding author