The basic principle of the preemptive analgesia is the administration of analgesics before the occurrence of painful stimulus in order to prevent pain, reducing the analgesic dosage, and compare the dosage required after the painful stimulus. It acts preventing or reducing the "memory" in the pain pathway in central nervous system. Preemptive analgesia may attenuate or prevent development of central sensibilization induced by surgery. This research aimed at evaluating the use of nonsteroidal anti-inflamatory (NSAID) ketoprofen as preemptive analgesic. Sixteen dogs were used, of varied age, female and male, and surgery of thoracotomies, the dogs received ketoprofen in Group K or distiled water as placebo in Group P, before surgical stimulation, the end surgery the animals received placebo in the Group K and Group P received ketoprofen. Parameters as cardiac and respiratory frequency, tidal volum and minute flow, blood gases and pain score were measured during six hours which followed the postoperative period. The utilized protocol has showed significative variations as bicarbonate and blood carbon dioxide, any significative statistical variations related in the pain scores. The results reported do not justify the use of NSAID ketoprofen as preemptive analgesic.
analgesia; preemptive; ketoprofen; dogs
