In order to evaluate osteoinduction and osteoconduction of the homologous demineralized bone matrix (DBM), processed in HCl 0.6 N solution for 24 hours and preserved in 70% ethanol solution, radial fragments were implanted in radius of adults rabbits. The animals were sacrificed at 3, 6, 9 and 12 post-operative weeks and the control group was sacrificed in 12 post-operative weeks. Radiographic exams of the operated radii were performed immediately after surgery and 3, 6, 9 and 12 post-operative weeks. After euthanasia, computed tomography, macroscopic, microscopic and tetracycline fluorescence exams were performed. DBM preserved its osteoinductive property and remains sterile. The empty spaces are favorable to osteoconduction and its growth factors induce osseous formation.
bone defects; bone graft; bone repair
