Chinese Shar-pei familial fever is a breed-associated hereditary autosomal recessive disease of Chinese Shar-pei dogs. A case of generalized amyloidosis in a 3-year-old female Chinese Shar-pei dog with a tentative diagnosis of familial Chinese Shar-pei fever is described. This animal had a clinical history of episodic bilateral swelling of the tarsal joints since 7-month-old. Vomiting, diarrhea, anorexia and lethargy were observed 3 days prior to death. At necropsy, both kidneys were firm, whitish and had an irregular capsular surface. Microscopically, amyloid deposits were observed in the kidneys, pancreas, thyroid glands and spleen. Amyloid deposits lost their affinity for Congo red after treatment with potassium permanganate indicating AA-type amyloidosis.
amyloidosis; Chinese Pei familial fever; uremia; renal disease
