In veterinary practice it is common to submit animals to chemotherapy for neoplasia control and to observe bone marrow depression, with presence of anemia, leukopenia and thrombocytopenia as collateral effects. In these cases, two therapeutical protocols can be adopted: chemotherapy by suppression and/or use of bone marrow stimulants. Nandrolone decanoate (Deca-durabolin®) is a bone marrow stimulant used in veterinary medicine despite few studies were conducted in domestic animals. The objective of this study was to analyse nandrolone decanoate (ND-1,5mg/kg, intramuscular), as a bone marrow stimulant in rats (Rattus rattus) with medular suppression induced by 4 and 8 mg/m² (intraperitoneal) of vincristine (Oncovin®). Hemogram, platelets counting and total plasma protein determination were evaluated. These results showed that its effectiveness in bone marrow stimulation depends on the degree of depression and the dose of administration.
stimulant; bone marrow; rat; nandrolone decanoate; vincristine
