In vitro screening for growth inhibition activity on cancer cell lines of northern Chile highlands shrubs

Triagem in vitro da atividade de inibição do crescimento em linhagens celulares de câncer em arbustos das montanhas do norte do Chile

ABSTRACT:

Cancer is still one of the leading causes of death worldwide. Many chemotherapeutics from plants have been tested in cancer, such as vinblastine and paclitaxel. The north of Chile, Arica & Parinacota region, is characterized by its vegetal biodiversity due to its unique geographical and climatological conditions, offering an unexplored and unique source of naturally-derived compounds. The present research has considered a screening of 26 highland herbs using an in vitro growth inhibition model in a panel of six cancer cell lines from different tissues. 5 of the 26 studied ethanolic extracts shows strong activity at least in one cell line when tested at 10 µg mL^-1. We present a group of plants worthy to be evaluated as promissory extracts. This work is part of the systematic attempt to find new candidates to be used in cancer therapies.

Key words:
Growth Inhibition; anticancer activity; highland medicinal plants; ethanolic extract; bioprospecting; northern Chile; Arica y Parinacota