ABSTRACT
Objective:
To compare the prognosis estimated by standard prognostic criteria versus the prognosis estimated by the Oncotype DX.
Methods:
A retrospective study was performed on 22 patients with positive estrogen receptor, early-stage breast cancer who had an Oncotype DX recurrence score available.
Results:
Kappa value between Oncotype DX and standard prognostic criteria was: Adjuvant! (K = 0.091), Adjuvant! (Transbig) (K = 0.182) and National Comprehensive Cancer Network (K = 0.091). The Fisher's exact test did not show correlation between Oncotype and standard prognostic criteria.
Conclusion:
Standard prognostic criteria showed no correlation with Oncotype DX.
Keywords:
Breast neoplasms/diagnosis; Gene expression profiling