| Plurad et al.(10)
|
United States |
2.403 |
To determine the effect of arginine vasopressin on organ recovery rates |
The use of arginine vasopressin with hormone replacement therapy is associated with increased organ recovery rates. This strategy should be universally adopted in donor maintenance |
| Dhar et al.(11)
|
United States |
2.872 |
To compare a lower-dose steroid protocol (suitable for stabilization of adrenal insufficiency and sepsis) to the traditional high-dose regimen in maintaining organ BD donors |
A lower dose corticosteroid protocol did not result in worsening donor lung or cardiac function compared to the traditional high dose regimen. Insulin requirements and glycemic control were improved. High-dose methylprednisolone may not be necessary to support BD donors |
| WestphaI et al.(12)
|
Brazil |
0.806 |
To establish guidelines for the care and maintenance of adult organ donors, guiding and standardizing the care of BD potential donors |
A protocol was developed with actions considered essential for organ donor maintenance: body temperature limits, laboratory tests indicated, blood pressure limits, and catecholamines used |
| Godino et al.(13)
|
Uruguay |
0.806 |
To identify and quantify the causes of exclusion of potential heart donors, and define the risk factors for ventricular dysfunction among the BD population |
Hemodynamic dysfunction in young people with head trauma was the main cause of heart donor loss. The use of vasopressors was observed in all patients investigated |
| Birtan et al.(14)
|
Turkey |
0.806 |
To investigate the effects of vasoactive drugs used in donor care on post-transplant kidney graft function |
Noradrenaline decreased the rejection rate and graft loss, presumably by improving hemodynamic stability and organ perfusion |
| Grigoras et al.(15)
|
Romania |
0.806 |
To investigate the evolution of the potential donor’s hemodynamic status from the BD declaration to organ removal (time in BD) |
The interval of hours between BD and harvest appears to have little influence on organ functionality when using early, aggressive, and registered donor management. Functional improvement can be achieved by duration of BD |
| Isnardi et al.(16)
|
Italy |
0.806 |
To present the use of ECMO as a bridge to organ procurement in a potential donor with hemodynamic instability |
ECMO can be used to prevent cardiac arrest, preserve organs, and thus increase the number of potential donors |
| Jeong et al.(17)
|
South Korea |
0.806 |
To determine the risk factors for organ recovery failure and complications during donor management |
BD-related complications were acute kidney injury, cardiopulmonary resuscitation, bacteremia, thrombocytopenia, and diabetes insipidus . Success rates of removal and transplantation remained low |
| Cavalcante et al.(18)
|
Brazil |
0.1047 |
To analyze the opinion of nurses about nursing care for BD patients and potential organ donors |
The nurses try to contemplate the technical and bioethical dimensions of care for the potential organ donor and family, although they recognize the complexity of the process and the need for better qualification and emotional maturity |
| Nicolas-Robin et al.(19)
|
France |
5.163 |
To investigate the benefit of a supplementary dose of hydrocortisone in BD patients in decreasing hemodynamic instability, and the need for noradrenaline |
The supplemental dose of hydrocortisone potentiated systemic hemodynamic stability, regardless of the pathophysiological state of the corticosteroids, with or without primary disease or secondary adrenal insufficiency in the patients. Thus, hydrocortisone infusion significantly reduced the dose of noradrenaline required for hemodynamic stability |
| Mojtabaee et al.(20)
|
Iran |
0.806 |
To describe the pediatric donors, their characteristics, complications, and the organ procurement process; to compare two age groups: under 5 years and those between 5 and 12 years |
Organs acquired from pediatric donors can be a valuable and life-saving solution for both children and adults. The different complications in donors under 5 years require attention in the protocols |
| Pinsard et al.(21)
|
France |
6.425 |
To study the impact of steroid administration on the recovery of function and the number of organs obtained compared to the number of potential BD donors |
Early replacement administration of glucocorticoids in an organ BD donor with circulatory failure allows the dose and duration of vasopressor administration to be significantly reduced |
| Kawati et al.(22)
|
Sweden |
1.971 |
To describe a case of traumatic femur fracture with fat embolism syndrome, which resulted in acute tonsillar herniation and subsequently, BD |
Deep sedation and permissive hypercapnia are established recommendations for maintenance of acute respiratory distress syndrome. Furthermore, prone position is an effective method to improve saturation in patients requiring high fractions of inspired oxygen. Intracranial pressure monitoring is a routine procedure to assess cerebral edema |
| Venkateswaran et al.(23)
|
United Kingdom |
3.960 |
To assess the prevalence of elevated inflammatory markers in potential heart and lung donors; to evaluate the impact of T3 and steroids administered during donor maintenance; to correlate the presence of biomarker levels with donor heart and lung function; and explore the value of these biomarkers in predicting transplant outcome |
Therapy with T3 or methylprednisolone do not affect the high prevalence of a pro-inflammatory environment in the organ donor. Elevated procalcitonin and tumor necrosis factor levels are associated with donor cardiac dysfunction. The evaluation of biomarkers can become a warning for intensive maintenance, to restore organs, and in donor maintenance and evaluation, to avoid organ rejection |
| Tamosuitis et al.(24)
|
Lithuania and the Netherlands |
2.170 |
To evaluate the conjunctival and sublingual microcirculation in BD patients, and compare with healthy volunteers in two opposite conditions: complete arrest versus normal arterial blood supply to the brain |
Compared to healthy controls, BD patients had significantly reduced conjunctival blood flow and microvascular density. However, the presence of conjunctival flow in the absence of cerebral flow makes it impossible to use the conjunctival microcirculation as a substitute for cerebral flow |
| Vorlat et al.(25)
|
Belgium |
7.955 |
To evaluate the potential value of BNP measured in a BD donor to predict early cardiac performance in the recipient |
Elevated BNP levels in cardiac allograft donors were inversely related to function in transplant recipients. Measuring BNP may be a useful tool in the evaluation of heart donors |
| Fugate et al.(26)
|
United States |
8.055 |
To characterize hemodynamic patterns after BD |
Early knowledge of blood pressure changes is important for clinicians performing BD examinations. Delayed BD declaration in a hemodynamically unstable patient may jeopardize harvest, and therefore, support for maintaining adequate arterial pressures is mandatory |
| Belzberg et al.(27)
|
United States |
0.46 |
To describe the temporal hemodynamic and oxygen transport patterns of trauma patients, such as those presenting BD |
The hyperdynamic state, with exaggerated peripheral perfusion and oxygenation, associated with loss of central vasoconstriction in BD patients, resulted from stress response mechanisms, as opposed to metabolic vasodilation, producing high cardiac output and tissue perfusion. The use of noninvasive hemodynamic monitoring for the measurement of cardiac output and tissue perfusion provides early recognition of flow and perfusion deficits |
| Nakawaga et al.(28)
|
United States |
1.818 |
To describe the physiology of the Cushing reflex after severe head trauma followed by progressive hypotension refractory to phenylephrine, responsive to vasopressin while awaiting organ procurement |
The early use of vasopressin, in addition to an alpha-adrenergic agonist, may be beneficial after BD by providing hemodynamic support, as well as by optimizing the quality of donor organs before transplantation |
| Giani et al.(29)
|
Italy |
15.008 |
To evaluate the feasibility and efficacy of an apnea testing technique that combines the application of PEEP with subsequent lung recruitment in a large cohort of BD patients |
The results of this study, in a large part of consecutive patients, including patients with venoarterial ECMO, demonstrated the strategy of apnea testing associated with the application of PEEP is feasible and practical |
| Robert et al.(30)
|
France |
2.872 |
To analyze the importance of donor factors, especially the potential role of hemodynamic management relative to delayed function of the transplanted kidney; to analyze urine from organ donors by proton magnetic resonance spectroscopy; and to identify urine markers potentially correlated with delayed renal function in transplanted patients |
Donor age, hemodynamic status, and hydroxyethyl starch infusion are risk factors for delayed function of the transplanted kidney |
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LILACS: Latin American and Caribbean Health Sciences Literature; SciELO: Scientific Electronic Library Online.