This text objective is to register reflections that permits a major understanding of the symbolization concept to introduce the issue of the symbolic subject constitution, implicated by mental deficiency. The reflections pass by meetings with different authors, from different areas of knowledge having the intention of making the choice of the historical-cultural perspectives with the one that best answers to the interrogations about the human being capable of giving meaning to the world, even being stopped by organic problems. The Vigotski and Bakhtin's contributions are fundamental. They conceive man as a being that signifies and constitutes himself in the concrete relations of life.