Coevolution in bean pathosystems have been demonstrated. Based on morphologial traits (seed color and size, growth habit, leaf shape, and pod size) seed protein type, serological reactions, isozymes analysis, and polymorphic patterns using molecular techniques (RFLP, RAPD, AFLP), two domestication centers of common bean have been proposed. They are Mesoamerica (Central America, the Caribbean and Mexico) and the Andean Region. Both wild and breed bean varieties are widely diverse in the two centers. The genetic variability is frequent among plant pathogen populations. On common beans, three pathogens have showed a strong association with the host gene pool, they are: Colletotrichum lindemuthianum, Phaeoisariopsis griseola and Uromyces appendiculatus. Most of their strains are host specific. However, the Mesoamerican pathogen populations are both more virulent and genetically variable than the Andean ones. The natural behavior of this pathosystem has suggested an ongoing coevolution process. To select appropriate sources of durable resistance and develop plant breeding programs it is necessary to know the genetic variability and specificity of native bean pathogen populations. Gene deployment is a suitable control strategy.