Epigenetic alterations in canine mammary cancer

Borges, Bárbara do Nascimento

doi:10.1590/1678-4685-GMB-2022-0131

Acessibilidade / Reportar erro

Brasil

Genetics and Molecular Biology

Español English

Brasil

Español English

sumário « anterior atual seguinte »

Sumário

Young Brazilian Geneticists - Special Issue • Genet. Mol. Biol. 45 (3 Suppl 1) • 2022 • https://doi.org/10.1590/1678-4685-GMB-2022-0131 copy

Epigenetic alterations in canine mammary cancer

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

In dogs, mammary cancer is the most common tumor type, especially in unspayed females. As in humans, this type of cancer has spontaneous development and is influenced by several risk factors, such as age and hormonal exposure in addition to genetic and epigenetic factors. Epigenetic mechanisms are responsible for gene expression modulation without alterations in the DNA sequence and include but are not limited to DNA methylation, histone modifications, and noncoding RNAs. Epigenetic patterns are known to influence a variety of biological mechanisms, such as cellular differentiation and development, and dysregulations of those patterns may result in several diseases, such as cancer. In this respect, this review summarizes the main findings concerning epigenetic alterations in canine mammary cancer, their relationship with the carcinogenic process, and their use as diagnostic and prognostic markers.

Keywords
Histone modifications; DNA methylation; ncRNA; biomarkers; comparative oncology

miRNA	Sample type	Expression	Clinical application	References
miR-18a	S	Up-regulated	Prognostic	Fish et al. (2020Fish EJ, Martinez-Romero EG, DeInnocentes P, Koehler JW, Prasad N, Smith AN and Bird RC (2020) Circulating microRNA as biomarkers of canine mammary carcinoma in dogs. J Vet Intern Med 34:1282-1290.)
miR-19b	S	Up-regulated	Diagnostic	Fish et al. (2020Fish EJ, Martinez-Romero EG, DeInnocentes P, Koehler JW, Prasad N, Smith AN and Bird RC (2020) Circulating microRNA as biomarkers of canine mammary carcinoma in dogs. J Vet Intern Med 34:1282-1290.)
miR-21	T/S	Up-regulated	Diagnostic and prognostic	Boggs et al. (2008Boggs RM, Wright ZM, Stickney MJ, Porter WW and Murphy KE (2008) MicroRNA expression in canine mammary cancer. Mamm Genome 19:561-569.); von Deetzen et al. (2014von Deetzen M-C, Schmeck BT, Gruber AD and Klopfleisch R (2014) Malignancy associated MicroRNA expression changes in canine mammary cancer of different malignancies. ISRN Vet Sci 2014:148597.); Bulkowska et al. (2017Bulkowska M, Rybicka A, Senses KM, Ulewicz K, Witt K, Szymanska J, Taciak B, Klopfleisch R, Hellmén E, Dolka I et al. (2017) MicroRNA expression patterns in canine mammary cancer show significant differences between metastatic and non-metastatic tumours. BMC Cancer 17:728.); Jain et al. (2021Jain M, Ingole SD, Deshmukh RS, Bharucha SV, Nagvekar AS, Gaikwad RV and Kharde SD (2021) CEA, CA 15-3, and miRNA expression as potential biomarkers in canine mammary tumors. Chromosom Res 29:175-188.); Ramadan et al. (2021Ramadan ES, Salem NY, Emam IA, AbdElKader NA, Farghali HA and Khattab MS (2021) MicroRNA-21 expression, serum tumor markers, and immunohistochemistry in canine mammary tumors. Vet Res Commun 46:377-388.)
miR-29b	T/S	Down-regulated	Diagnostic and prognostic	Bulkowska et al. (2017Bulkowska M, Rybicka A, Senses KM, Ulewicz K, Witt K, Szymanska J, Taciak B, Klopfleisch R, Hellmén E, Dolka I et al. (2017) MicroRNA expression patterns in canine mammary cancer show significant differences between metastatic and non-metastatic tumours. BMC Cancer 17:728.); Jain et al. (2021Jain M, Ingole SD, Deshmukh RS, Bharucha SV, Nagvekar AS, Gaikwad RV and Kharde SD (2021) CEA, CA 15-3, and miRNA expression as potential biomarkers in canine mammary tumors. Chromosom Res 29:175-188.)
	T/S	Up-regulated	Diagnostic	Boggs et al. (2008Boggs RM, Wright ZM, Stickney MJ, Porter WW and Murphy KE (2008) MicroRNA expression in canine mammary cancer. Mamm Genome 19:561-569.); Fish et al. (2020Fish EJ, Martinez-Romero EG, DeInnocentes P, Koehler JW, Prasad N, Smith AN and Bird RC (2020) Circulating microRNA as biomarkers of canine mammary carcinoma in dogs. J Vet Intern Med 34:1282-1290.)
miR-96	T/S	Up-regulated	Diagnostic	Jeong et al. (2019Jeong S-J, Lee K-H, Nam A-R and Cho J-Y (2019) Genome-wide methylation profiling in canine mammary tumor reveals miRNA candidates associated with human breast cancer. Cancers (Basel) 11:1466.)
miR-101	T/S	Down-regulated	Diagnostic	von Deetzen et al. (2014von Deetzen M-C, Schmeck BT, Gruber AD and Klopfleisch R (2014) Malignancy associated MicroRNA expression changes in canine mammary cancer of different malignancies. ISRN Vet Sci 2014:148597.); Bulkowska et al. (2017Bulkowska M, Rybicka A, Senses KM, Ulewicz K, Witt K, Szymanska J, Taciak B, Klopfleisch R, Hellmén E, Dolka I et al. (2017) MicroRNA expression patterns in canine mammary cancer show significant differences between metastatic and non-metastatic tumours. BMC Cancer 17:728.)
miR-125a	T/S	Down-regulated	Prognostic	von Deetzen et al. (2014von Deetzen M-C, Schmeck BT, Gruber AD and Klopfleisch R (2014) Malignancy associated MicroRNA expression changes in canine mammary cancer of different malignancies. ISRN Vet Sci 2014:148597.); Bulkowska et al. (2017Bulkowska M, Rybicka A, Senses KM, Ulewicz K, Witt K, Szymanska J, Taciak B, Klopfleisch R, Hellmén E, Dolka I et al. (2017) MicroRNA expression patterns in canine mammary cancer show significant differences between metastatic and non-metastatic tumours. BMC Cancer 17:728.)
	S	Up-regulated	Diagnostic	Fish et al. (2020Fish EJ, Martinez-Romero EG, DeInnocentes P, Koehler JW, Prasad N, Smith AN and Bird RC (2020) Circulating microRNA as biomarkers of canine mammary carcinoma in dogs. J Vet Intern Med 34:1282-1290.)
miR-126	P	Up-regulated	Diagnostic	Heishima et al. (2017Heishima K, Ichikawa Y, Yoshida K, Iwasaki R, Sakai H, Nakagawa T, Tanaka Y, Hoshino Y, Okamura Y, Murakami M et al. (2017) Circulating microRNA-214 and -126 as potential biomarkers for canine neoplastic disease. Sci Rep7:2301.)
miR-143	T/S	Down-regulated	Prognostic	von Deetzen et al. (2014von Deetzen M-C, Schmeck BT, Gruber AD and Klopfleisch R (2014) Malignancy associated MicroRNA expression changes in canine mammary cancer of different malignancies. ISRN Vet Sci 2014:148597.); Bulkowska et al. (2017Bulkowska M, Rybicka A, Senses KM, Ulewicz K, Witt K, Szymanska J, Taciak B, Klopfleisch R, Hellmén E, Dolka I et al. (2017) MicroRNA expression patterns in canine mammary cancer show significant differences between metastatic and non-metastatic tumours. BMC Cancer 17:728.)
miR-145	T/S	Down-regulated	Prognostic	von Deetzen et al. (2014von Deetzen M-C, Schmeck BT, Gruber AD and Klopfleisch R (2014) Malignancy associated MicroRNA expression changes in canine mammary cancer of different malignancies. ISRN Vet Sci 2014:148597.); Bulkowska et al. (2017Bulkowska M, Rybicka A, Senses KM, Ulewicz K, Witt K, Szymanska J, Taciak B, Klopfleisch R, Hellmén E, Dolka I et al. (2017) MicroRNA expression patterns in canine mammary cancer show significant differences between metastatic and non-metastatic tumours. BMC Cancer 17:728.)
miR-149	T/S	Down-regulated	Diagnostic	Jeong et al. (2019Jeong S-J, Lee K-H, Nam A-R and Cho J-Y (2019) Genome-wide methylation profiling in canine mammary tumor reveals miRNA candidates associated with human breast cancer. Cancers (Basel) 11:1466.)
miR-194	T	Up-regulated	Diagnostic	von Deetzen et al. (2014von Deetzen M-C, Schmeck BT, Gruber AD and Klopfleisch R (2014) Malignancy associated MicroRNA expression changes in canine mammary cancer of different malignancies. ISRN Vet Sci 2014:148597.)
miR-195	T/CL	Down-regulated	Diagnostic	Zhang et al. (2021)
miR-210	T/S	Down-regulated	Diagnostic	von Deetzen et al. (2014von Deetzen M-C, Schmeck BT, Gruber AD and Klopfleisch R (2014) Malignancy associated MicroRNA expression changes in canine mammary cancer of different malignancies. ISRN Vet Sci 2014:148597.); Bulkowska et al. (2017Bulkowska M, Rybicka A, Senses KM, Ulewicz K, Witt K, Szymanska J, Taciak B, Klopfleisch R, Hellmén E, Dolka I et al. (2017) MicroRNA expression patterns in canine mammary cancer show significant differences between metastatic and non-metastatic tumours. BMC Cancer 17:728.)
miR-214	P	Up-regulated	Diagnostic	Heishima et al. (2017Heishima K, Ichikawa Y, Yoshida K, Iwasaki R, Sakai H, Nakagawa T, Tanaka Y, Hoshino Y, Okamura Y, Murakami M et al. (2017) Circulating microRNA-214 and -126 as potential biomarkers for canine neoplastic disease. Sci Rep7:2301.)
miR-497	T/CL	Down-regulated	Diagnostic	Zhang et al. (2021)
miR-8832	T/S	Up-regulated	Diagnostic	Jeong et al. (2019Jeong S-J, Lee K-H, Nam A-R and Cho J-Y (2019) Genome-wide methylation profiling in canine mammary tumor reveals miRNA candidates associated with human breast cancer. Cancers (Basel) 11:1466.)

Sociedade Brasileira de Genética Rua Cap. Adelmio Norberto da Silva, 736, 14025-670 Ribeirão Preto SP Brazil, Tel.: (55 16) 3911-4130 / Fax.: (55 16) 3621-3552 - Ribeirão Preto - SP - Brazil
E-mail: editor@gmb.org.br

Acompanhe os números deste periódico no seu leitor de RSS

[1] Send correspondence to
Bárbara do Nascimento Borges. Universidade Federal do Pará, Instituto de Ciências Biológicas, Laboratório de Biologia Molecular “Francisco Mauro Salzano”, Rua Augusto Correa, 01, Guamá, 66075-110, Belém, PA, Brazil. E-mail: bnborges@ufpa.br