<i>FABP4</i> and omentin-1 gene expression in epicardial adipose tissue from coronary artery disease patients

Miroshnikova, Valentina V.; Polyakova, Ekaterina A.; Pobozheva, Irina A.; Panteleeva, Aleksandra A.; Razgildina, Natalia D.; Kolodina, Diana A.; Belyaeva, Olga D.; Berkovich, Olga A.; Pchelina, Sofya N.; Baranova, Elena I.

doi:10.1590/1678-4685-GMB-2020-0441

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Human and Medical Genetics • Genet. Mol. Biol. 44 (4) • 2021 • https://doi.org/10.1590/1678-4685-GMB-2020-0441 copy

FABP4 and omentin-1 gene expression in epicardial adipose tissue from coronary artery disease patients

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

Omentin-1 and fatty acid-binding protein 4 (FABP4) are adipose tissue adipokines linked to obesity-associated cardiovascular complications. The aim of this study was to investigate epicardial adipose tissue (EAT) omentin-1 and FABP4 gene expression in obese and non-obese patients with coronary artery disease (CAD). Omentin-1 and FABP4 mRNA levels in EAT and paired subcutaneous adipose tissue (SAT) as well as adipokine serum concentrations were assessed in 77 individuals (61 with CAD; 16 without CAD (NCAD)). EAT FABP4 mRNA level was decreased in obese CAD patients when compared to obese NCAD individuals (p=0.001). SAT FABP4 mRNA level was decreased in CAD patients compared to NCAD individuals without respect to their obesity status (p=0.001). Omentin-1 mRNA level in EAT and SAT did not differ between the CAD and NCAD groups. These findings suggest that omentin-1 gene expression in adipose tissue is not changed during CAD; downregulated FABP4 gene expression in SAT is associated with CAD while EAT FABP4 gene expression is decreased only in obesity-related CAD.

Keywords:
Coronary artery disease; epicardial adipose tissue; subcutaneous adipose tissue; FABP4; omentin-1

	CAD patients N=61		NCAD patients (Control group) N=16
	Obese N=31	Non-obese N=30	Obese N=7	Non-obese N=9
Age, years	60.6±9.1	61.7±8.1	67.0±3.5	55.8±15.8
Male/female	17/14	24/6	1/6	7/2
Waist circumference, cm	Males: 111 (103-120)^§ Females: 95 (91-113)^§	Males: 94 (81-101)^# Females: 82 (79-85)	Male: 103 Females: 96 (91-104)	Males: 83 (69-100) Females: 63.5 (58-69)
BMI, kg/m2	31.4±4.5*	25.9±2.7	28.8±4.1	26.7±9.8
EAT thickness, mm	5.3±1.9*^#	7.2±2.6	6.2±1.4	5.2±2.0
Gensini Score	74 (38-148)	71 (10-202)	-	-
Triglyceride, mmol/L	1.98±1.03*	1.41±0.57	1.86±1.14	1.01±0.48
Total cholesterol, mmol/L	4.43±1.27*	5.21±1.76	5.02±0.88	4.23±1.02
HDL-cholesterol, mmol/L	1.32±0.32	1.25±0.33	1.22±0.22	1.17±0.48
LDL-cholesterol, mmol/L	2.17±1.06*	3.14±1.28	2.94±0.44	2.73±0.63
Fasting glucose, mmol/L	5.95±0.79	5.49±0.92	5.60±1.44	5.41±1.41
Medications, N (%)
Statins	19 (61%)	16 (53%)	1 (14%)	1 (11%)
Aspirin	18 (58%)	18 (60%)	0 (0%)	0 (0%)
Nitrates	9 (29%)	10 (33%)	0 (0%)	0 (0%)
ACEI/ARB	5 (16%)	4 (13%)	0 (0%)	0 (0%)
Beta-blockers	22 (71%)	25 (83%)	1 (14%)	2 (22%)
Calcium channel blockers	6 (19%)	7 (23%)	0 (0%)	0 (0%)

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[1] Send correspondence to
Valentina Miroshnikova. Pavlov First Saint Petersburg State Medical University, L’va Tolstogo str. 6-8 building 28, 197022, St.-Petersburg, Russian Federation. E-mail: miroshnikova_vv@pnpi.nrcki.ru.