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Surgery for Otitis Media with Effusion: A Survey of Otolaryngologists Who Treat Children in Brazil

Abstract

Introduction

Myringotomy and ear tube placement (MTP) is the surgical treatment for otitis media with effusion (OME), and it is the most common surgery performed in children. Several guidelines have been developed to assist in the care of patients who become candidates for MTP.

Objectives

To evaluate the practice of Brazilian otorhinolarynogologists when performing MTP according to the years of clinical experience. Secondarily, we also want to assess if their practice regarding MTP varied according to the percentage of children treated and the location of their practice.

Methods

A 30-question survey was sent to otolaryngologists affiliated with the Brazilian Academy of Pediatric Otorhinolaryngology (Academia Brasileira de Otorrinolaringologia Pediátrica, ABOPe, in Portuguese) and/or the Scientific Department of Otorhinolaryngology of the Brazilian Society of Pediatrics (Sociedade Brasileira de Pediatria, SBP, in Portuguese). The questions included were carefully chosen to provide a profile about the practices adopted in the pre-, peri- and postoperative periods of MTP.

Results

The questionnaire was sent to 208 otolaryngologists, and there were 124 (59.6%) respondents. Of those, 59.7% use antiseptics before surgery. Only 54 otolaryngologists, less than half of the subjects in this study (43.5%), always place a tube during the procedure. More physicians who practice in small cities recommend water precautions after MTP when compared to other physicians (p < 0.001).

Conclusions

The present study reveals that many respondents do not follow some of the recommendations of the current guidelines of the American Academy of

Keywords
otitis media with effusion; tympanostomy tube insertion; children; survey

Introduction

Otitis media with effusion (OME) is defined as the presence of fluid inside the middle ear with no associated systemic and local signs of infection (acute otitis media, AOM).11 Stool SE, Berg AO, Berman S, et al. Otitis Media with Effusion in Young Children: Clinical Practice Guideline No. 12. Rockville, MD: Agency for Healthcare Research and Quality; 1994 AHCPR publication 94-0622.,22 Berkman ND, Wallace IF, Steiner MJ, et al. Otitis Media With Effusion: Comparative Effectiveness of Treatments [Internet]. Rockville, MD: Agency for Healthcare Research and Quality (US); 2013,33 Rosenfeld RM, Shin JJ, Schwartz SR, et al. Clinical practice guideline: otitis media with effusion (update). Otolaryngol Head Neck Surg 2016;154(1, Suppl)S1–S41,44 NICE. Otitis Media with effusion in under 12s: surgery Guidance and guidelines. 2008,55 Simon F, Haggard M, Rosenfeld RM, Jia H, Peer S, Calmels MN, Couloigner V, Teissier N. International consensus (ICON) on management of otitis media with effusion in children. European Annals of Otorhinolaryngology, Head and Neck Diseases 2018; 135(01):S33–S39 Extremely common in infants in the first year of life, more than 50% of children develop OME, a rate that increases to more than 60% at 2 years of life.66 Casselbrant ML, Mandel EM. Epidemiology. In: Rosenfeld RM, Bluestone CD, eds. Evidence-Based Otitis Media. 2nd ed. Hamilton, Canada: BC Decker Inc; 2003:147–162

According to the major international guidelines,33 Rosenfeld RM, Shin JJ, Schwartz SR, et al. Clinical practice guideline: otitis media with effusion (update). Otolaryngol Head Neck Surg 2016;154(1, Suppl)S1–S41,44 NICE. Otitis Media with effusion in under 12s: surgery Guidance and guidelines. 2008,55 Simon F, Haggard M, Rosenfeld RM, Jia H, Peer S, Calmels MN, Couloigner V, Teissier N. International consensus (ICON) on management of otitis media with effusion in children. European Annals of Otorhinolaryngology, Head and Neck Diseases 2018; 135(01):S33–S39 OME is the most common indication for myringotomy and ear tube placement (MTP), which is believed to be the most common ear, nose, and throat (ENT) surgery performed in children.33 Rosenfeld RM, Shin JJ, Schwartz SR, et al. Clinical practice guideline: otitis media with effusion (update). Otolaryngol Head Neck Surg 2016;154(1, Suppl)S1–S41,44 NICE. Otitis Media with effusion in under 12s: surgery Guidance and guidelines. 2008,55 Simon F, Haggard M, Rosenfeld RM, Jia H, Peer S, Calmels MN, Couloigner V, Teissier N. International consensus (ICON) on management of otitis media with effusion in children. European Annals of Otorhinolaryngology, Head and Neck Diseases 2018; 135(01):S33–S39 In the United States, it is the most common pediatric outpatient surgery,77 Proceedings from the National Summit on Overuse. 2012. The Joint Commission. https://www.jointcommission.org/assets/1/6/National_Summit_Overuse.pdf. Accessed December 21, 2016.
https://www.jointcommission.org/assets/1...
with 667 thousand procedures performed in children under 15 years in 2006.88 Kleinman LC, Kosecoff J, Dubois RW, Brook RH. The medical appropriateness of tympanostomy tubes proposed for children younger than 16 years in the United States. JAMA 1994;271(16): 1250–1255 In 2010, 2.5% of all children over 2 years of age underwent MTP.99 Grindler DJ, Blank SJ, Schulz KA, Witsell DL, Lieu JE. Impact of Otitis Media Severity on Children’s Quality of Life. Otolaryngol Head Neck Surg 2014;151(02):333–340. Doi: 10.1177/0194599814525576
https://doi.org/10.1177/0194599814525576...

There is a plethora of studies in the literature11 Stool SE, Berg AO, Berman S, et al. Otitis Media with Effusion in Young Children: Clinical Practice Guideline No. 12. Rockville, MD: Agency for Healthcare Research and Quality; 1994 AHCPR publication 94-0622.,22 Berkman ND, Wallace IF, Steiner MJ, et al. Otitis Media With Effusion: Comparative Effectiveness of Treatments [Internet]. Rockville, MD: Agency for Healthcare Research and Quality (US); 2013,33 Rosenfeld RM, Shin JJ, Schwartz SR, et al. Clinical practice guideline: otitis media with effusion (update). Otolaryngol Head Neck Surg 2016;154(1, Suppl)S1–S41,44 NICE. Otitis Media with effusion in under 12s: surgery Guidance and guidelines. 2008,55 Simon F, Haggard M, Rosenfeld RM, Jia H, Peer S, Calmels MN, Couloigner V, Teissier N. International consensus (ICON) on management of otitis media with effusion in children. European Annals of Otorhinolaryngology, Head and Neck Diseases 2018; 135(01):S33–S39,66 Casselbrant ML, Mandel EM. Epidemiology. In: Rosenfeld RM, Bluestone CD, eds. Evidence-Based Otitis Media. 2nd ed. Hamilton, Canada: BC Decker Inc; 2003:147–162 on OMEn addressing children, ethnicities, ages, predisposing factors and accompanying factors, but none focusing on surgeon practices.

The objective of the present study is to determine the practice of Brazilian otorhinolarynogologists when performing MTP according to the years of clinical experience. Secondarily, we also want to assess if their practice regarding MTP varied according to the percentage of children treated and the location of their practice.

Material and Methods

In Brazil, there were 5,399 registered medical doctors specializing in otorhinolaryngology in 2018, according to the Brazilian Federal Council of Medicine (Conselho Federal de Medicina, in Portuguese).1010 Abrahão M, Ed. Censo ABORL-CCF 2018. DOC contentRio de Janeiro2018:1–88 Myringotomy and ear tube placement is a common procedure in ENT surgery that is performed by most otolaryngologists. The aim of the present study was to evaluate the practice of otolaryngologists affiliated with the Brazilian Academy of Pediatric Otorhinolaryngology (Academia Brasileira de Otorrinolaringologia Pediátrica, ABOPe, in Portuguese) and/or the Scientific Department of Otorhinolaryngology of the Brazilian Society of Pediatrics (Sociedade Brasileira de Pediatria, SBP, in Portuguese) regarding MTP. This small group (n = 208) was selected because it represents most otolaryngologists who have a greater focus on pediatric patient care in Brazil. It is important to emphasize that in Brazil there is no recognized specialty, subspecialty or qualification in pediatric otolaryngology yet, although there are already nine fellowships training programs in the subspecialty in different states of the country (https://www.abope.org.br/programa-de-aper-feicoamento-fellowships/).

An online questionnaire (►attachment 1 online) covering questions about the MTP procedure was developed and sent only to otolaryngologists affiliated with the ABOPe and/or the Scientific Department of Otorhinolaryngology of the SBP.

In the present study, the focus is not on the pathology, but on the surgical procedure (MTP) adopted by surgeons. The questions included in the questionnaire were carefully chosen to provide a profile of the Brazilian ENT surgeon regarding the practices followed in MTP in the pre-, peri- and postoperative periods.

In December 2018, an electronic invitation to fill out the online survey was sent. A follow-up reminder on WhatsApp was sent a month later. Two months to fill out the questionnaire were allocated; no incentives were given, and the survey was completely voluntary and anonymous.

The thirty questions were on the practices and procedures followed by the otolaryngologist surgeon exclusively during the surgery to place the ventilation tube. The respondents were evaluated in terms of three aspects: years of clinical experience (since finishing residency); percentage of pediatric patients cared for in their practice; and location of the practice, whether large (in state capitals), in the countryside, or in coastal cities.

All variables were analyzed descriptively. For the qualitative variables, absolute and relative frequencies were calculated. To test the homogeneity among proportions, the Chisquared test or the Fisher exact test1111 Rosner B. - Fundamentals of Biostatistics - Boston. PWS PublishersSecond edition 1986:584pp.,1212 Fleiss JL. Statistical methods for rates and proportions. New York: John Wiley; 1981:212–36 were used. The software used for the calculations was the Statistical Package for the SocialSciences(SPSS Statistics for Windows, SPSS Inc., Chicago, IL, United States), version 17.0.

The protocol of the present study was approved by the institutional Ethics in Research Committee under number 4.287.630.

Results

Responses were obtained from 124 (59.6%) out of 208 physicians. ►Table 1 shows the distribution the variables related to the procedure, such as antibiotic prescription, water care recommendations, type of ventilation tube used according to the presence or absence of comorbidities and surgical technique used. Most surgeons always place tubes (43.5%), regardless of the presence or not of effusion at the moment of surgery, and do not prescribe antibiotics in the postoperative period (against 27.4% who do). However, most (11.3%) do not prescribe water precautions. The most used tube for patients with and without comorbidities is Paparella, manufacturer: Medtronic (38.7%) and Sheppard, manufacturer: Medicone (67.7%), respectively.

Table 1
Distribution of frequencies of the variables evaluated in the study

Table 2 describes the physicians’ demographics: years of clinical practice, percentage of pediatric patients cared for, and location of their practice. Most respondents (44.4% – 55 professionals) had less than 10 years of experience in the profession. Only 11.3% of doctors (14 professionals) cared exclusively for children, and the vast majority (67.7% – 84 professionals) work in large cities.

Table 2
Absolute and relative frequencies regarding the years of practice, the percentage of pediatric patients and the location of the pratice of the study sample

Table 3 is related to the main null hypothesis (H0). There was no difference in the distribution of variables according to surgeon’s years of experience. Professionals with less than 10 years of experience are the ones who least indicate protection against water (8 doctors), compared to those who have been practicing for more than 30 years. There is also a significant difference between the time the doctors worked and the indication of personalized earplugs (p < 0.013). Otolaryngologists with more than 20 years of practice recommend them most often. There was also a significant difference between the years of experience and the indication of custom-molded ear plugs (p < 0,013): ENTs who have more than 20 years of practice recommend those more often.

Table 3
Absolute and relative frequencies of the questions evaluated according to the years of practice

The prescription of antibiotics decreases regarding the percentage of pediatric patients cared for: physicians who have less than 25% of pediatric patients in their practice prescribe systemic antibiotics more often, followed byphysicians who have 25% to 50%, 50% to 75%, and 100% of pediatric patients in their practice (p = 0.01) (►Table 4). Otolaryngologists with less than 10 years of training more often recommend the use of cotton soaked in oil as a precaution against water. Regarding the prescription of antibiotics, there was no statistically significant difference among the physicians with 25% to 50% and 50% to 75% of pediatric patients (p = 0.353), but there was a significantly higher percentage of professionals (those who have less than 25% of children in their practice) who prescribe antibiotics (46.2% – 6 doctors) when compared to the group that exclusively cares for children (0%) (p < 0.001). Physicians who only care for children tend to discourage swimming and diving postoperatively less often than physicians who care for both children and adults (p = 0.014 and p < 0.001 respectively) (►Table 4).

Table 4
Absolute and relative frequencies of the questions evaluated according to the percentage of pediatric patients cared for

Finally, there was a significant difference among the groups interms of location of the practice and the recommendation of postoperative water protection with cotton soaked in oil: physicians who work in the countryside recommend more that type of protection than those who work in large and/or coastal cities (p < 0.01). There was also a significant difference in terms of the location of the practice and the type of ventilation tube used in patients without comorbidities: in the countryside, there was a greater percentage of physicians who use the Sheppard tube, and in large and/or costal cities, doctors tend to use more the Donaldson tube(Medicone, Porto Alegre, RS, Brazil) (►Table 5).

Table 5
Absolute and relative frequencies of the questions evaluated according to the location where the physician works

Discussion

The response rate obtained of almost 60% is quite good, since the rate considered acceptable for this type of survey research is of about 40%.1313 Story DA, Tait AR. Survey Research. Anesthesiology 2019;130(02): 192–202

The majority (55.6%) of the respondents were otorhinolaryngologists with more than 10 years of experience in the specialty. Only 11.3% (14 doctors) of the sample cared exclusively for pediatric patients, which is compatible with the fact that Brazil does not have a recognized subspecialty in the field of pediatric otolaryngology. This situation may change in the near future because of the increasing number of young otolaryngologists who are finishing their training in the new pediatric otolaryngology fellowship programs held in Brazil.

The results of the present study reinforce the benefits of subspecialization. Younger physicians in the profession, and those who are dedicated exclusively to children, behave more in line with the latest global guidelines on the treatment of OME. That is the case, for example, of the prescription of water precautions. In a systematic review, Moualed et al.1414 Moualed D, Masterson L, Kumar S, Donnelly N. Water precautions for prevention of infection in children with ventilation tubes (grommets). Cochrane Database Syst Rev 2016;(01):CD010375 concluded against the routine use of water-related precautions based on limited clinical benefits, highlighting the associated cost, the inconvenience of protection, and the anxiety resulting from the guidance and care. In a retrospective cohort, Subtil et al.1515 Subtil J, Jardim A, Peralta Santos A, AraújoJ, SaraivaJ,Paço J. Water protection after tympanostomy (Shepard) tubes does not decrease otorrhea incidence - retrospective cohort study. Rev Bras Otorrinolaringol (Engl Ed) 2018;84(04):500–505 concluded that recommending water protection has no beneficial effect on the incidence of otorrhea after MTP. They emphasize that such preventive measures do not seem to have an impact on quality of life. One year after, the same group published a randomized, well-designed clinical trial1616 Subtil J, Jardim A, Araujo J, et al. Effect of Water Precautions on Otorrhea Incidence after Pediatric Tympanostomy Tube: Randomized Controlled Trial Evidence. Otolaryngol Head Neck Surg 2019; 161(03):514–521 showing that the incidence of otorrhea did not differ between groups with or without hearing protection during exposure to water, which corroborates current guidelines that state that routine water precautions are unnecessary in this population. In the present study, we observed tha some type of water protection is recommend by 88.3% (110 individuals) of physicians, but physicians who have most recently completed residency the shorter the time after graduating from residency, the less common is the recommendation recommend of water precautions the least. In the present study, we observed that some type of precaution against water is recommended by 88.7% (110 individuals) of physicians; the fewer years in the profession, the less common is the water protection recommendation. Perhaps younger physicians are more up-to-date on current guidelines.

There is no recommendation to clean the external auditorycanal before the MTP (since this practice does not change the incidence of otorrhea or postoperative complications),1717 Scott BA, Strunk CL Jr. Post-tympanostomy otorrhea: a randomized clinical trial of topical prophylaxis. Otolaryngol Head Neck Surg 1992;106(01):34–41. Doi: 10.1177/019459989210600125
https://doi.org/10.1177/0194599892106001...
,1818 Odutoye T, McGilligan A, Robb PJ. Aseptic surgical technique and postgrommet otorrhoea. Int J Pediatr Otorhinolaryngol 2003;67 (Suppl 1):S233–S235. Doi: 10.1016/j.ijporl.2003.08.035
https://doi.org/10.1016/j.ijporl.2003.08...
but 47 respondents (37.9%) prepare before the procedure. It was also interesting to see that most respondents who prep use aqueous chlorhexidine as an antiseptic. It is important to highlight that there are studies1919 Singh S, Blakley B. Systematic review of ototoxic pre-surgical antiseptic preparations - what is the evidence? J Otolaryngol Head and Neck Surgery 2018;47(01):1–6 showing the possible ototoxicity of certain antiseptic solutions, such as chlorhexidine and iodine.

Although most respondents (72.6% – 90 doctors) still use the surgical microscope, some use of the endoscope in isolation or associated with the microscope. The endoscope has been used more frequently in several otological surgeries, from MTP to more complex procedures, such as resection of vestibular schwannomas.2020 João PV. The role of the endoscope in otologic surgery. Rev Bras Otorrinolaringol (Engl Ed) 2019;85(05):543–545 The endoscope can provide better visualization of the tympanic membrane in patients with a narrow ear canal, and may have better image quality when compared to older microscopes. However, it requires a learning curve. What we have observed in our medical residency services in otorhinolaryngology is the increasingly frequent use of endoscopes in ear surgeries by younger physicians.

The tympanic membrane quadrants used for paracentesis are well defined. In the poll conducted by Todd2121 Todd NW. What your colleaguesthinkoftympanostomytubes–28 years later. Laryngoscope 1999;109(7 Pt 1):1028–1032 in 1999, the sites most chosen for paracentesis were the anteroinferior and posteroinferior quadrants of the tympanic membrane. These locations were also chosen by most respondents in the present study (97.6% – 121 doctors).

For the surgical treatment of OME, the guidelines of the American Academy of Otorhinolaryngology-Head and Neck Surgery (AAO-HNS)33 Rosenfeld RM, Shin JJ, Schwartz SR, et al. Clinical practice guideline: otitis media with effusion (update). Otolaryngol Head Neck Surg 2016;154(1, Suppl)S1–S41 and the international consensus (ICON) on the management of OME in children2222 Simon F, Haggard M, Rosenfeld RM, et al. International consensus (ICON) on management of otitis media with effusion in children. Eur Ann Otorhinolaryngol Head Neck Dis 2018;135(1S):S33–S39 recommend MTP as the main surgical procedure. Ventilation tube placement is a preoperative indication; does not depend on a specific intraoperative finding. It is debatable, since no guideline in the literature states that the placement of the ventilation tube depends on an intraoperative surgical finding, such as the presence of effusion (glue ear). In the present study, less than half of the otolaryngologists (43.5% – 54doctors) always place the ventilation tube after the child has already been anesthetized. It seems that, for this sample of Brazilian otolaryngologists, placing the ventilation tube is not a pre-operative indication, but a factor that depends on an intraoperative finding (the presence of effusion). The major inconsistency is to indicate an MTP surgery, submit the patient to general anesthesia, and not place the ventilation tube in a surgery whose only objective is to improve the dysfunction in the Eustachian tube by placing a pressure-equalizing tube.

In the present study, there was no controversy about the types of ventilation tubes used. In the case of children without comorbidities, the most used ventilation tube is the Sheppard, followed by the Donaldson tube. For children with comorbidities such as syndromes and cleft palate, the Paparella and Tube T are the most used. In the study conducted by Todd2121 Todd NW. What your colleaguesthinkoftympanostomytubes–28 years later. Laryngoscope 1999;109(7 Pt 1):1028–1032 in 1999, Teflon and Silastic were the most frequently-used materials. In the study by Rosenfeld et al.2323 Rosenfeld RM, Schwartz SR, Pynnonen MA, et al. Clinical practice guideline: Tympanostomy tubes in children. Otolaryngol Head Neck Surg 2013;149(1, Suppl)S1–S35 (2013), the short-term tube most used in Europe, China and South Africa was the Shepard (made of fluoroplastic or titanium, similar to the type-1 Paparella ear tube).

Another issue addressed is the efficacy of middle-ear irrigations, either during MTP or in the immediate postoperative period, in reducing infections. In a study, Gross et al.2424 Gross RD, Burgess LP, Holtel MR, et al. Saline irrigation in the prevention of otorrhea after tympanostomy tube placement. Laryngoscope 2000;110(2 Pt 1):246–249 (2000) concluded that using irrigation with pure saline in the middle ear in the intraoperative period may be more effective than antibiotic drops to prevent otorrhea in the postoperative period. In a systematic review evaluating the occurrence of otorrhea at least two weeks after MTP, Venekamp et al.2525 Venekamp RP,Javed F, van Dongen TMA, Waddell A,Schilder AGM. Interventions for children with ear discharge occurring at least two weeks following grommet (ventilation tube) insertion. Cochrane Database Syst Rev 2016;11:CD011684 (2016) found moderate to low-grade evidence that antibiotic ear drops (with or without corticosteroids) are more effective when compared with oral antibiotics, corticosteroid ear drops, or without any treatment. The authors2525 Venekamp RP,Javed F, van Dongen TMA, Waddell A,Schilder AGM. Interventions for children with ear discharge occurring at least two weeks following grommet (ventilation tube) insertion. Cochrane Database Syst Rev 2016;11:CD011684 have also reported that there is limited, inconclusive evidence that antibiotic ear drops are more effective than local washing with saline, and there is no confirmation that antibiotic ear drops with corticosteroids are more effective than those without corticosteroids.

Conclusion

The present study revealed that many otolaryngologists do not followsome of the recommendations of the current AAO-HNS guidelines on OME, either perioperatively and postoperatively, or regarding the placement of a ventilation tube. This part of the care also varied depending on the respondents’ work location and experience in the medical practice.

Note

  • All authors have actively participated in the writing of the present article, and they have all contributed equally to it.
  • The present study was chosen for oral presentation at the 2020 Annual Meeting of the Society for Ear, Nose, and Advancement of Throat in Children (SENTAC).

References

  • 1
    Stool SE, Berg AO, Berman S, et al. Otitis Media with Effusion in Young Children: Clinical Practice Guideline No. 12. Rockville, MD: Agency for Healthcare Research and Quality; 1994 AHCPR publication 94-0622.
  • 2
    Berkman ND, Wallace IF, Steiner MJ, et al. Otitis Media With Effusion: Comparative Effectiveness of Treatments [Internet]. Rockville, MD: Agency for Healthcare Research and Quality (US); 2013
  • 3
    Rosenfeld RM, Shin JJ, Schwartz SR, et al. Clinical practice guideline: otitis media with effusion (update). Otolaryngol Head Neck Surg 2016;154(1, Suppl)S1–S41
  • 4
    NICE. Otitis Media with effusion in under 12s: surgery Guidance and guidelines. 2008
  • 5
    Simon F, Haggard M, Rosenfeld RM, Jia H, Peer S, Calmels MN, Couloigner V, Teissier N. International consensus (ICON) on management of otitis media with effusion in children. European Annals of Otorhinolaryngology, Head and Neck Diseases 2018; 135(01):S33–S39
  • 6
    Casselbrant ML, Mandel EM. Epidemiology. In: Rosenfeld RM, Bluestone CD, eds. Evidence-Based Otitis Media. 2nd ed. Hamilton, Canada: BC Decker Inc; 2003:147–162
  • 7
    Proceedings from the National Summit on Overuse. 2012. The Joint Commission. https://www.jointcommission.org/assets/1/6/National_Summit_Overuse.pdf Accessed December 21, 2016.
    » https://www.jointcommission.org/assets/1/6/National_Summit_Overuse.pdf
  • 8
    Kleinman LC, Kosecoff J, Dubois RW, Brook RH. The medical appropriateness of tympanostomy tubes proposed for children younger than 16 years in the United States. JAMA 1994;271(16): 1250–1255
  • 9
    Grindler DJ, Blank SJ, Schulz KA, Witsell DL, Lieu JE. Impact of Otitis Media Severity on Children’s Quality of Life. Otolaryngol Head Neck Surg 2014;151(02):333–340. Doi: 10.1177/0194599814525576
    » https://doi.org/10.1177/0194599814525576
  • 10
    Abrahão M, Ed. Censo ABORL-CCF 2018. DOC contentRio de Janeiro2018:1–88
  • 11
    Rosner B. - Fundamentals of Biostatistics - Boston. PWS PublishersSecond edition 1986:584pp.
  • 12
    Fleiss JL. Statistical methods for rates and proportions. New York: John Wiley; 1981:212–36
  • 13
    Story DA, Tait AR. Survey Research. Anesthesiology 2019;130(02): 192–202
  • 14
    Moualed D, Masterson L, Kumar S, Donnelly N. Water precautions for prevention of infection in children with ventilation tubes (grommets). Cochrane Database Syst Rev 2016;(01):CD010375
  • 15
    Subtil J, Jardim A, Peralta Santos A, AraújoJ, SaraivaJ,Paço J. Water protection after tympanostomy (Shepard) tubes does not decrease otorrhea incidence - retrospective cohort study. Rev Bras Otorrinolaringol (Engl Ed) 2018;84(04):500–505
  • 16
    Subtil J, Jardim A, Araujo J, et al. Effect of Water Precautions on Otorrhea Incidence after Pediatric Tympanostomy Tube: Randomized Controlled Trial Evidence. Otolaryngol Head Neck Surg 2019; 161(03):514–521
  • 17
    Scott BA, Strunk CL Jr. Post-tympanostomy otorrhea: a randomized clinical trial of topical prophylaxis. Otolaryngol Head Neck Surg 1992;106(01):34–41. Doi: 10.1177/019459989210600125
    » https://doi.org/10.1177/019459989210600125
  • 18
    Odutoye T, McGilligan A, Robb PJ. Aseptic surgical technique and postgrommet otorrhoea. Int J Pediatr Otorhinolaryngol 2003;67 (Suppl 1):S233–S235. Doi: 10.1016/j.ijporl.2003.08.035
    » https://doi.org/10.1016/j.ijporl.2003.08.035
  • 19
    Singh S, Blakley B. Systematic review of ototoxic pre-surgical antiseptic preparations - what is the evidence? J Otolaryngol Head and Neck Surgery 2018;47(01):1–6
  • 20
    João PV. The role of the endoscope in otologic surgery. Rev Bras Otorrinolaringol (Engl Ed) 2019;85(05):543–545
  • 21
    Todd NW. What your colleaguesthinkoftympanostomytubes–28 years later. Laryngoscope 1999;109(7 Pt 1):1028–1032
  • 22
    Simon F, Haggard M, Rosenfeld RM, et al. International consensus (ICON) on management of otitis media with effusion in children. Eur Ann Otorhinolaryngol Head Neck Dis 2018;135(1S):S33–S39
  • 23
    Rosenfeld RM, Schwartz SR, Pynnonen MA, et al. Clinical practice guideline: Tympanostomy tubes in children. Otolaryngol Head Neck Surg 2013;149(1, Suppl)S1–S35
  • 24
    Gross RD, Burgess LP, Holtel MR, et al. Saline irrigation in the prevention of otorrhea after tympanostomy tube placement. Laryngoscope 2000;110(2 Pt 1):246–249
  • 25
    Venekamp RP,Javed F, van Dongen TMA, Waddell A,Schilder AGM. Interventions for children with ear discharge occurring at least two weeks following grommet (ventilation tube) insertion. Cochrane Database Syst Rev 2016;11:CD011684

Publication Dates

  • Publication in this collection
    09 June 2023
  • Date of issue
    Apr 2023

History

  • Received
    15 July 2021
  • Accepted
    20 Oct 2021
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