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Articles • J. Braz. Chem. Soc. 27 (5) • May 2016 • https://doi.org/10.5935/0103-5053.20150342   copy

An Efficient and Chemoselective Deprotection of Aryl tert-Butyldimethylsilyl (TBDMS) Ethers by NaCN

Authorship SCIMAGO INSTITUTIONS RANKINGS

Phenolic tert-butyldimethylsilyl (TBDMS) ethers can be deprotected to yield phenols in excellent yield using sodium cyanide (NaCN) as catalyst in ethanol. The deprotectation of various phenolic TBDMS ethers were found to be very convenient, fast, high yielding and chemoselective.

Keywords:
deprotectection; tert-butyldimethylsilyl; sodium cyanide

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